Pulmonary Arterial Hypertension (PAH) Market – Market Insights

Pulmonary Arterial Hypertension (PAH) is a rare disease, which affects the pulmonary arteries. High blood pressure in the lungs is called pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). It is characterized by narrowed and blocked arteries and capillaries. This rare disease usually grows worse over the period and may result to death if left untreated.

Market players are focusing on collaborations & mergers to develop novel products in the pulmonary arterial hypertension (PHA) market, which is expected to boost growth of the market over the forecast period. For instance, in 2017, Bayer AG and Vectura Group Plc. extended their collaboration to develop an upgraded version of nebulizer Breelib, which improves the efficacy of iloprost aerosol therapy for pulmonary atrial hypertension. Moreover, according to the National Institute of Health, the nebulizer is still in clinical trial and the study is expected to finish by March 2020.  

Furthermore, ongoing regulatory approvals for the products by the market players is expected to fuel the market growth over the forecast period. For instance, in March 2016, Actelion Pharmaceuticals Ltd, the Janssen Pharmaceutical Companies of Johnson & Johnson Services Inc., received the approval for Uptravi (selexipag) for the treatment of pulmonary arterial hypertension. The Medicines and Medical Devices Safety Authority (Medsafe) approved the drug in the New Zealand and the Therapeutic Goods Administration (TGA) approved in Australia.

The global pulmonary arterial hypertension (PAH) market was valued at US$ 5,821.90 million in 2018, and is expected to exhibit a CAGR of 5.9% over the forecast period (2019-2027).

Figure 1. Global Pulmonary Arterial Hypertension (PHA) Market Value (US$ Mn), by Region, 2018

Pulmonary Arterial Hypertension (PAH)  | Coherent Market Insights

Source: Coherent Market Insights Analysis (2019)

Rising cases of heart problems leading to pulmonary arterial hypertension (PHA) is expected to boost growth of the global pulmonary arterial hypertension (PHA) market

The global pulmonary arterial hypertension (PHA) market is expected to witness significant growth over the forecast period, owing to rising cases of heart disorders, which leads to pulmonary arterial hypertension (PHA). For instance, according to the Center for Disease Control and Prevention (CDC), a report- Prevalence of uncontrolled risk factors for cardiovascular disease – May 2019 states that, in the U.S. someone has a heart attack every 40 seconds. The report also states that each year, around 805,000 people in the U.S. have a heart attack.

Figure 2. Global Pulmonary Arterial Hypertension (PHA) Market Share (%), by Drug Type, 2019 and 2027

Pulmonary Arterial Hypertension (PAH)  | Coherent Market Insights

Source: Coherent Market Insights Analysis (2019)

Increasing collaborations for novel product development and rising cases of pulmonary hypertensions are expected to drive the market growth

North America is expected to hold a dominant position in the global pulmonary arterial hypertension (PHA) market, owing to increasing strategic partnerships and collaborations by key players, which is expected to drive the North America market growth over the forecast period. For instance, in September 2018, United Therapeutics entered into a collaboration with MannKind Corporation for the development and commercialization of dry powder formulation of treprostinil. These companies also aimed to enter in a research agreement for the conduct of research by MannKind. This research was had to be performed by Mannkind on behalf of United Therapeutics for products outside the scope of the licensing and collaboration agreement.

Moreover, Europe is expected to be the second dominating region in the global pulmonary arterial hypertension (PHA) market, owing to rising cases of pulmonary arterial hypertension (PHA) in the region. For instance, according to the Health and Social Care Information Centre, National Audit of Pulmonary Hypertension - 2015, the study published in 2016 reports that 57.0% of patients were treated with pulmonary hypertension drug therapy in Great Britain, 56.0% in England, 63.0% in Scotland, and 73.0% in Wales.

Key Players

Major players operating in the global pulmonary arterial hypertension (PHA) market include United Therapeutics Corporation, GlaxoSmithKline plc, Novartis AG, AstraZeneca, Bayer AG, Merck KGaA, Pfizer Inc., Gilead Sciences, Inc., Actelion Pharmaceuticals Ltd, Arena Pharmaceuticals, and Daiichi Sankyo Company, Limited.

Pulmonary arterial hypertension is a rare diseases that is caused due to various factors such as congestive heart failure, liver diseases, autoimmune diseases, which includes Lupus, scleroderma, rheumatoid arthritis, and others. This disease is considered rare but life-threatening condition that gets worse over time. The narrowed and blocked arteries with the high pressure of blood is called as pulmonary arterial hypertension (PAH) and pulmonary hypertension (PH). The tiny arteries in the lungs become narrow and blocked, which makes difficult to pump blood through these arteries and later leads to weaken the heart muscle. Rising cases of causes of pulmonary arterial hypertension (PAH) is expected to fuel growth of the market in the forecast period. For instance, according to the American College of Cardiology Foundation published an article Heart Disease and Stroke Statistics-2019, a report from the American Heart Association, around 795,000 U.S. population have a new or recurrent stroke annually, in which 90.0% of stroke risk is due to modifiable risk factors and 74.0% is due to behavioral risk factors.

Furthermore, approvals of drugs through the regulatory bodies for the treatment of pulmonary arterial hypertension (PAH) are expected to fuel growth of the market. For instance, in September 2017, Actelion Pharmaceuticals, Ltd. received a New Drug Application (NDA) approval from the U.S. Food and Drug Administration for Tracleer (bosentan), a 32 mg dispersible tablets. This drug got approval for the treatment of Pulmonary Arterial Hypertension in adult and pediatric patients.

Market Dynamics

The pulmonary arterial hypertension (PAH) market is expected to witness significant growth over the forecast period, owing to increasing number of heart failures which later leads to pulmonary arterial hypertension (PAH) cases. For instance, in 2019, Heart Failure Society of America reports that around 550,000 new cases of heart failure are diagnosed each year in the U.S. and nearly 1.4 million persons with congestive heart failure (CHF) are under 60 years of age.

Product approvals by regulatory authorities are expected to drive growth of pulmonary arterial hypertension (PAH) market over the forecast period. For instance, in 2013, the U.S. Food and Drug Administration approved Actelion Ltds’ Opsumit (Macitentan) for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression. The drug is novel dual endothelin receptor antagonist (ERA), a 10 mg oral tablet available to address efficacy and safety.

Moreover, in November 2018, Arena Pharmaceuticals and United Therapeutics entered into an exclusive license agreement related to Ralinepag (Potent IP Receptor Agonist), which was evaluated for the treatment of pulmonary arterial hypertension. Under the agreement, United Therapeutics got an exclusive and irrevocable license to develop, manufacture and commercialize ralinepag in any formulation for pulmonary arterial hypertension (PAH).

Key features of the study:

  • This report provides in-depth analysis of the pulmonary arterial hypertension (PAH) market and provides market size (US$ Mn) and compound annual growth rate (CAGR %) for the forecast period (2019 -2027), considering 2018 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, market trends, regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global pulmonary arterial hypertension (PAH) market based on the following parameters – company overview, financial performance, product portfolio, market presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as part of this study include United Therapeutics Corporation, GlaxoSmithKline plc, Novartis AG, AstraZeneca, Bayer AG, Merck KGaA, Pfizer Inc., Gilead Sciences, Inc., Actelion Pharmaceuticals Ltd, Arena Pharmaceuticals, and Daiichi Sankyo Company, Limited.
  • Insights from this report would allow marketers and management authorities of companies to make informed decisions regarding future product launches, technology upgradation, market expansion, and marketing tactics
  • The global pulmonary arterial hypertension (PAH) market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the Pulmonary Arterial Hypertension (PAH) market

Detailed Segmentation:

  • Global Pulmonary Arterial Hypertension (PAH) market, By Drug Type:
    • Endothelin Receptor Antagonists (ERAs)
    • Phosphodiesterase-5 (PDE-5) Inhibitors
    • Soluble Guanylate Cyclase (sGC) Stimulators
    • Prostacyclin Analogue
    • Calcium Channel Blockers
    • Others
  • Global Pulmonary Arterial Hypertension (PAH) market, By Route of Administration:
    • Oral
    • Inhaled
    • Intravenous
    • Subcutaneous
  • Global Pulmonary Arterial Hypertension (PAH) market, By Distribution Channel
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
  • Global Pulmonary Arterial Hypertension (PAH) market, By Region:
    • North America
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Pakistan
        • Rest of Asia Pacific
    • Middle East
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Drug Type:
        • Endothelin Receptor Antagonists (ERAs)
        • Phosphodiesterase-5 (PDE-5) Inhibitors
        • Soluble Guanylate Cyclase (sGC) Stimulators
        • Prostacyclin Analogue
        • Calcium Channel Blockers
        • Others
      • By Route of Administration:
        • Oral
        • Inhaled
        • Intravenous
        • Subcutaneous
      • By Distribution Channel:
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country/Region:
        • North Africa
        • Central Africa
        • South Africa
  • Company Profiles
    • United Therapeutics Corporation*
      • Company Highlights
      • Products Portfolio
      • Key Highlights
      • Financial Performance
      • Market Strategies
    • GlaxoSmithKline plc.
    • Novartis AG
    • AstraZeneca
    • Bayer AG
    • Merck KGaA
    • Pfizer Inc.
    • Gilead Sciences, Inc.
    • Actelion Pharmaceuticals Ltd
    • Arena Pharmaceuticals
    • Daiichi Sankyo Company, Limited

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Drug Type
      • Market Snippet, By Route of Administration
      • Market Snippet, By Distribution Channel
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Key Developments
    • Regulatory Guidelines
    • Regulatory Scenario
    • Merger & Acquisitions
    • Product Launch
    • Epidemiology
    • Pipeline Analysis
    • New Product Launches
    • List of Approved Products
    • Pest Analysis
  4. Global Pulmonary Arterial Hypertension (PAH) Market, By Drug Type, 2016 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Endothelin Receptor Antagonists (ERAs)
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Phosphodiesterase-5 (PDE-5) inhibitors
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Soluble Guanylate Cyclase (sGC) Stimulators
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Prostacyclin Analogue
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Calcium Channel Blockers
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  5. Global Pulmonary Arterial Hypertension (PAH) Market, By Route of Administration, 2016 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Oral
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Inhaled
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Intravenous
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Subcutaneous
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  6. Global Pulmonary Arterial Hypertension (PAH) Market, By Distribution Channel, 2016 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Hospital Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Retail Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Online Pharmacies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  7. Global Pulmonary Arterial Hypertension (PAH) Market, By Region, 2016 – 2027, (US$ Mn)
    • Introduction
      • Market Share Analysis, By Region, 2016 and 2026 (%)
      • Y-o-Y Growth Analysis, For Regions, 2017–2027
    • North America
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • U.S.
        • Canada
    • Latin America
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Drug Type, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Mn)
      • Market Size and Forecast, By Country/Region, 2016 – 2027, (US$ Mn)
        • South Africa
        • Central Africa
        • North Africa
  8. Competitive Landscape
    • Heat Map Analysis
    • Market Share Analysis
      • United Therapeutics Corporation
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • GlaxoSmithKline plc.
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Novartis AG
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • AstraZeneca
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Bayer AG
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Merck KGaA
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Pfizer Inc.
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Gilead Sciences, Inc.
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Actelion Pharmaceuticals Ltd
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Arena Pharmaceuticals
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
      • Daiichi Sankyo Company, Limited
        • Company Highlights
        • Products Portfolio
        • Key Highlights
        • Financial Performance
        • Strategies
    • Analyst Views
  9. Section
    • References
    • Research Methodology
    • About Us and Sales Contact
  •  

*Browse 39 market data tables and 25 figures on "Pulmonary Arterial Hypertension (PAH) Market - Global forecast to 2027”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users