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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Polymer chain reaction (PCR) creates unlimited copies of DNA from a single strand using polymerase enzymes, primers, and multiple thermal cycles. PCR diagnostics are less prone to cross-contamination, as the procedure is conducted in automated thermal cyclers. dPCR and qPCR are common diagnostic techniques used in the research, pharma, and biotech institutes, and are widely used in variety of applications.

Real-time PCR allows specific and early disease diagnosis, allowing speedy and selective treatment for the patient. Also, PCR techniques have replaced the conventional infectious disease detection methods such as immunoassays as they are more specific and have become an integral part of laboratory diagnosis, thereby facilitating market growth.

Digital PCR and Real-time PCR (qPCR) Market: Dynamics

Increasing adoption of qPCR in medical diagnosis to detect RNA viruses such as HIV and hepatitis C is expected to propel the market growth. According to the International Journal of Nanomedicine, 2017, around 36.7 million people were affected by human immunodeficiency virus (HIV) and around 400 million people were affected with viral hepatitis, globally. The survey also stated that with no reliable treatment for HIV infection, early diagnosis is a critical factor in managing AIDS patients, as it is a major cause for morbidity and mortality, globally.

Moreover, launch of technologically advanced products is expected to enhance the market growth. For instance, in November 2013, GNA Biosolutions GmbH launched an ultrafast PCR platform, Pharos V8 platform based on laser PCR. The platform uses nanomaterial to accelerate PCR reaction, by a factor of ten, thus making it suitable to be used in time-sensitive settings.

However, high device cost and adoption of alternative assays for disease detection and analysis is expected to hinder the market growth.

Digital PCR and Real-time PCR (qPCR) Market: Regional Analysis

North America is expected to hold dominant position in the digital PCR and real-time PCR market, owing to increasing number of cancer cases, favoring the demand for PCR diagnostic tools and assays. According to a National Cancer Institute, 2016, an estimated 1,735,350 million new cases of cancer will be diagnosed in the U.S., with around 609,640 deaths from the disease in 2018. The number of people suffering from cancer is expected to rise to 19 million by 2024.

Digital PCR and Real-time PCR (qPCR) Market: Key Players

Key players operating in the global digital PCR and real-time PCR market include Thermo Fisher Scientific, Inc., Bio-Rad Laboratories, Inc., Abbott Laboratories, F. Hoffmann-La Roche Ltd., Qiagen N.V., Takara Bio, Inc., Danaher Corporation, Merck KGaA, Becton, Dickinson and Company, and Agilent Technologies, Inc.

Key development

  • In April 2019, Thermo Fisher Scientific Inc. introduced Applied Biosystems QuantStudio 6 and 7 Pro Real-Time PCR Systems, which includes new specifications like facial authentication, voice command and radiofrequency identification.
  • In January 2019, QIAGEN N.V. announced the development of range of next-generation systems for the digital polymerase chain reaction (digital PCR or dPCR) one of the fastest-growing molecular testing applications, which is expected to launch in 2020.
  • In 2017, Bio-Rad Laboratories, Inc. introduced iQ-Check Enterobacteriaceae real-time PCR detection kit that can be used for 94 samples.
  • In 2017, Agilent Technologies Inc. launched AriaDx Real-Time PCR System for Clinical Diagnostics in Europe to expand its molecular diagnostic portfolio.
  • In 2016, Danaher Corporation acquired Cepheid Inc. to expand its qPCR-product portfolio.

Digital PCR and Real-time PCR (qPCR) Market: Taxonomy

The global digital PCR and real-time PCR market is segmented on the basis of technology, product type, application, end user, and region.

By Technology:

  • Quantitative PCR (qPCR)
  • Digital PCR (dPCR)

By Product Type:

  • Reagents and Consumables
  • Instruments

By Application:

  • Clinical
    • Pathogen Testing
    • Oncology Testing
    • Blood Screening
    • Others
  • Research
  • Forensic

By End User:

  • Hospitals and Diagnostic Centers
  • Academic & Research Institutes
  • Pharmaceutical and Biotechnology Industries
  • Others

By Region:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users