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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Traumatic brain injury (TBI) is a condition in which the brain is injured by external forces such as accidents, sports injuries, and sometimes physical aggression. According to The Centers for Disease Control and Prevention’s (CDC) definition, TBI is disruption in the normal function of the brain that can be caused by a bump, blow, or jolt to the head, or penetrating head injury. TBI can affect a person physically and psychologically. Some of symptoms of TBI can be observed immediately after injury and other can arise after some time interval. TBI can be classified as mild and severe. Mild TBI can temporarily affect the brain cells while severe TBI can result in bruising, torn tissues, bleeding, and other physical damage to the brain. TBI shows several physical, sensory, and cognitive or mental symptoms. Complications associated with TBI include, altered consciousness, physical complication such as seizures, headache, vertigo, and infections (Meningitis), intellectual problem, communication problem, sensory problem, and degenerative brain diseases. Treatments for TBI are based on the severity of the injury.

Traumatic Brain Injury Therapeutics Market: Drivers

Increasing number of pipeline studies to develop new treatments for TBI is expected to boost the traumatic brain injury therapeutics market growth during the forecast period. For instance, in August 2017, Australian and New Zealand Intensive Care Research Center, in collaboration with Monash University, initiated a clinical trial to determine long-term effects of erythropoietin in patients with moderate to severe TBI. Erythropoietin is a hormone produced by the kidneys and plays crucial role in the production of red blood cells (RBCs). The study is expected to be completed by May 2019.

Similarly, in June 2016, Vasopharm GmbH, in collaboration with ICON plc, started phase 3 clinical study for VAS203 (Ronopterin) to evaluate its efficacy in patients with moderate and severe TBI (NOSTRA-III). The study is expected to be completed by June 2019.

However, delayed diagnosis of TBI may hinder the traumatic brain injury therapeutics market growth. After brain injury, brain undergoes hyper-metabolic state as it tries to protect itself after injury. This hyper-metabolic activity mask the symptoms of brain injuries which may result into delayed diagnosis of TBI.

Traumatic Brain Injury Therapeutics Market: Regional Analysis

On the basis of region, the global traumatic brain injury therapeutics market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to account for the largest market share in the traumatic brain injury therapeutics market, owing to increasing incidences of TBI in the U.S. For instance, according to CDC, in 2013, around 2.5 million patients with TBI visited the emergency department and around 282,000 patients with TBI were hospitalized in U.S. Moreover, according to the same source, around 56,000 deaths are registered, annually due to TBI, accounting for 30% of all injury related deaths in U.S.

Furthermore, Europe is expected to account for the second largest market share in the traumatic brain injury therapeutics market, owing to increasing government initiatives to develop new treatment options for TBI. For instance, in 2017, ICON plc. announced its contribution with pan-European traumatic brain injury (TBI) research study involving over 4,500 patients in 65 sites in 20 European countries. ICON provided site management and source data verification (SDV) services to the study. The study was initiated with the support of European Union.

Key players operating in the global traumatic brain injury therapeutics market include, Teva Pharmaceutical Industries Ltd., Sanofi, Novartis AG, Pfizer Inc., Akorn Pharmaceuticals, Arbor Pharmaceuticals, F. Hoffmann-La Roche Ltd., Invagen pharms, Lupin, Apotex Inc., Mylan N.V., Neuren Pharmaceuticals Ltd., Oxygen Biotherapeutics Inc., and Avanir Pharmaceuticals Inc.

Traumatic Brain Injury Therapeutics Market: Taxonomy

By Treatment Type

  • Drugs
    • Antianxiety
    • Anticoagulants
    • Antidepressants
    • Muscles relaxants
    • Stimulants
    • Other Medications

By Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

By Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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