Bowen disease treatment market

Bowen disease is the early form of squamous cell carcinoma and is also known as squamous cell carcinoma in situ. For instance, according to an article published by the Open Access Macedonian Journal of Medical Sciences in February 2019, it is estimated that around 3- 5% of noninvasive Bowen disease develops into an invasive squamous cell carcinoma, a more serious form of skin cancer which can spread throughout the body. Bowen disease is characterized by the presence of red scaly patches or lesions on various parts of the body which are most exposed to the sun such as hands, legs, feet, and others. These lesions or scaly patches are usually asymptomatic i.e. they are usually not associated with symptoms such as pain, bleeding, and others. Some of the risk factors associated with Bowen disease include ionizing radiation, human papillomavirus (HPV) infection, sun exposure, exposure to arsenic, immunosuppressive drugs, and others. In cases, where Bowen disease affects the genitals in men, it is known as erythroplasia of Queyrat. Bowen disease can be diagnosed with the help of a tissue biopsy of the affected area and can be treated using chemotherapy, cryotherapy, photodynamic therapy, surgery, and others.

The global Bowen disease treatment market is estimated to be valued at US$ 356.5 million in 2021 and is expected to exhibit a CAGR of 4.5% over the forecast period (2021-2028).

Figure 1. Global Bowen Disease Treatment Market Share (%), By Region, 2021

The increasing incidence of squamous cell carcinoma in situ (Bowen disease) is expected to drive the growth of the global Bowen disease treatment market over the forecast period.

For instance, according to an article published by the JAMA Dermatology journal in July 2020, a study of 88,754 patients suffering from Bowen disease in Netherlands between January 1, 1989, and December 31, 2017 reveals that the incidence of Bowen disease (cutaneous squamous cell carcinoma in situ) had increased from 1989 to 2017 in Netherlands with the highest incidence of Bowen disease in 2017. The incidence rate was found to be 71.7 cases per 100,000 person-years in 2017 among women and 540.9 cases per 100,000 person-years among men.

Figure 2. Global Bowen Disease Treatment Market Value (US$ Mn), By Drug Type, 2021

The increasing research and development activities for the development of novel therapeutics for the treatment of Bowen disease is expected to drive the market growth over the forecast period.

For instance, in February 2021, Ponce Therapeutics, a U.S. based biotechnology company, announced the launch of its first research and development plan for the treatment of skin conditions such as Bowen disease, aging, and others. The company has hired its first scientists for executing its research and development plan. The research and development plan would majorly focus on p16 cell proliferation inhibitor, which is highly expressed in Bowen disease. This research and development plan would thus help in development of the company’s first product for regulatory approval as well as launch.

Global Bowen Disease Treatment Market – Impact of Coronavirus (Covid-19) Pandemic

Coronavirus (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19, as pandemic on March 11, 2020. According to the Coronavirus (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 252,826,597 cases and 5,092,761 deaths due to coronavirus (COVID-19) were reported till November 14, 2021, across the globe.

The COVID-19 pandemic and lockdown in various countries across the globe has negatively impacted the financial status of businesses across all sectors. The COVID-19 pandemic has impacted the entire supply chain of the healthcare industry mainly due to strict lockdown in several regions. Likewise, COVID-19 pandemic is expected to have a negative impact on the global Bowen disease treatment market over the forecast period, owing to disruption in cancer treatment services and halt of clinical trials related to treatment of cancer (including Bowen disease). For instance, according to a report published by the World Health Organization in July 2020, around 42% of the countries across the world have disrupted services for cancer treatment in lieu of COVID-19 pandemic.

Global Bowen Disease Treatment Market Restraint

The side effects of chemotherapy drugs used in the treatment of Bowen disease are the factors that are expected to hinder growth of the global Bowen disease treatment market over the forecast period. For instance, according to an article published by the StatPearls journal in July 2021, topical application of fluorouracil, a chemotherapy drug used for treatment of Bowen disease is associated with adverse effects such as pain, crusting, erythema, and others.

Key Players

Major players operating in the global Bowen disease treatment market include Galderma S.A., Sirnaomics, Inc., PEPLIN INC, Ponce Therapeutics, Intas Laboratories Pvt Ltd, Cadila, Pharmaceuticals Ltd., VHB Life Sciences Limited, Neon Laboratories Ltd, Teva Pharmaceutical Ltd, and Actavis Group