Single use bioreactor market

The global single-use bioreactor market was valued at US$ 1,001.0 Mn in 2021 and is forecast to reach a value of US$ 2,768.3 Mn by 2028 at a CAGR of 15.6% between 2022 and 2028. The global single-use bioreactor market is experiencing strong growth due to the increase in adoption of single-use bioreactors and increasing demand for biologics across the globe. Moreover, rising burden of chronic and infectious disease and the outbreak of COVID-19 is expected to boost the market growth. However, factors such as regulatory concerns related to single-use bioreactors and high regular recurring expenses are expected to hamper growth of the market.

Global Single-Use Bioreactor Market: Regional Insights

Based on geography, the global single-use bioreactor market is segmented into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa.

Among regions, North America is expected to gain highest share in the market during the forecast period owing to the increasing burden of chronic diseases and increase in adoption of single-use technologies by market players in the region. For instance, according to the Centers for Disease Control and prevention (CDC), chronic diseases, such as heart disease, cancer, and diabetes, are the leading causes of death and disability in the U.S. Six in ten Americans live with at least one chronic disease, like heart disease and stroke, cancer, or diabetes. This in turn is expected to propel the growth of the market in the region.

Asia Pacific is also expected to witness robust growth in the global single-use bioreactor market owing to the increasing prevalence of chronic diseases and rapid growth of the in pharmaceutical industry the region. For instance, according to the Indian Brand Equity Foundation (IBEF), India’s domestic pharmaceutical market stood at US$ 42 billion in 2021 and is expected to reach around US$ 65 billion by 2024 and to reach US$ 120-130 billion by 2030. Safety, lower costs, and reduced downtime are the major reasons for the expansion of single-use bioreactors in the pharmaceutical industry, driving the growth of the market.

Figure 1. Global Single-Use Bioreactor Market Share (%), by Region, 2021

Global Single-Use Bioreactor Market Drivers:

Rise in adoption of single-use bioreactors by the pharmaceutical industry is expected to augment growth of the global single-use bioreactor market during the forecast period. For instance, single-use bioreactors are emerging as a key technology in the field of pharmaceuticals. In March 2021, Thermo Fisher rolled out 3,000 and 5,000 L single-use bioreactors (S.U.B). The first-of-its-size 5,000 L S.U.B. is Thermo’s largest commercially available S.U.B., enabling biopharmaceutical companies to integrate single-use technologies into large-scale bioprocesses, including perfusion cell culture and cGMP manufacturing at very high cell density.

Increasing demand for biologics across the globe is expected to boost growth of the global single-use bioreactor market over the forecast period. For instance, the increase in the development of biologics around the world has led to an increase in demand for SUBs. In November 2022, Juvena Therapeutics, Inc. raised US$ 41 million in an oversubscribed Series A, bringing its total funding to US$ 50 million. The new funding will power the expansion of Juvena’s drug discovery platform and advance the company’s biologics pipeline targeting chronic and age-related diseases. This in turn is driving the single-use bioreactor market growth.

Global Single-Use Bioreactor Market Opportunities:

Rising burden of chronic and infectious disease across the world is expected to offer significant growth opportunities for players in the single-use bioreactor market. For instance, bioreactors have been used for decades to produce a range of therapeutics, showing promise for the treatment of many acute and chronic diseases. Chronic diseases are the leading causes of death and disability worldwide. According to the World Health Organization (WHO), cardiovascular diseases account for most NCD deaths, or 17.9 million people annually, followed by cancers (9.3 million), chronic respiratory diseases (4.1 million), and diabetes (2.0 million).

Outbreak of COVID-19 around the world is expected to provide significant growth opportunities for players in the global single-use bioreactor market. For instance, bioreactors are being widely used in cell culture-based viral vaccine production, particularly during the COVID-19 pandemic. In September 2020, ABEC delivered six 4,000L CSR bioreactors to Serum Institute of India to speed up the production of NVX CoV2373, Novavax’ COVID-19 vaccine candidate. Moreover, Serum Institute had used ABEC’s single-use technology to accelerate supply of NVX CoV2373 throughout India and other low- and middle-income countries.

Global Single-Use Bioreactor Market Trends:

Single-use bioreactors are particularly suitable for biopharmaceutical production, where prevailing market trends call for quick, easy and flexible deployment. Single-use bioreactors enhance process safety and reduce the risk of cross contamination in highly potent biopharmaceutical ingredients with extensive validation and qualification processes. As a result, there is an increase in demand for single-use bioreactors, and this trend is expected to continue during the forecast period.

Moreover, there is an increase in demand for single-use bioreactors due to the increase in chronic diseases coupled with the emerging need for developing new drugs. Chronic diseases, such as heart disease, cancer, and diabetes, are the leading causes of death and disability worldwide. Thus, with the increase in prevalence of chronic diseases, the need for developing new drugs is also increasing with a rapid pace. This trend is expected to continue over the forecast period, driving the growth of the global single-use bioreactor market.

Global Single-Use Bioreactor Market Restraints:

Regulatory concerns related to single-use bioreactors is expected to hamper growth of the global single-use bioreactor market. For instance, SUBs have become an established addition to today’s biotechnology manufacturing facility. Many single-use bioreactors are made of plastic derivatives. Large-scale disposal of such plastic reactors is an environmental concern, and a major challenge, especially in countries where plastic disposal is strictly regulated.

High regular recurring expenses are expected to hinder growth of the single-use bioreactor market. For instance, recurring expenses for single-use bioreactors has been found to be high. Moreover, the cost involved in the waste management of large quantities of disposables is also high. SUBs incur more disposal costs compared to reusable units, which already has high upfront costs in terms of installation and maintenance.

Figure 2. Global Single-Use Bioreactor Market Share (%), by Product, 2021

Global Single-Use Bioreactor Market Segmentation:

The global single-use bioreactor market report is segmented into Product, Cell Type, Molecule Type, End User, and Geography.

Based on Product, the single-use bioreactor market is segmented into Single-Use Bioreactor Systems, Media Bags, Filtration Assemblies, and Other Products. Out of which, Single-Use Bioreactor Systems Segment is expected to dominate the single-use bioreactor market over the forecast period and this is attributed to the increase in adoption of single-use bioreactors by the pharmaceutical and biopharmaceutical industries.

Media Bags Segment is also expected to witness significant growth in the near future and this is owing to the advantages of using media bags and advancements in the bag material.

Based on Cell Type, the market is segmented into Mammalian Cell, Bacteria, Yeast, and Other Cell Types. Out of which, Mammalian Cell Segment is expected to dominate the market over the forecast period and this is attributed to the rise in mammalian cell culture. Single-use bioreactors are ideally used for the mammalian cell bioprocessing.

Bacteria Segment is also expected to witness robust growth in the near future and this is owing to the increase use of single-use bioreactor in bacterial culture.

Based on Molecule Type, the market is segmented into Vaccines, Monoclonal Antibodies, Stem Cells, Recombinant Proteins, and Other Molecule Types. Out of which, Vaccines Segment is expected to dominate the market over the forecast period and this is attributed to the outbreak of COVID-19. Bioreactors are widely used in cell culture-based viral vaccine production, especially during the COVID-19 pandemic.

Stem Cells Segment is also expected to witness significant growth in the near future and this is owing to the increase in development of regenerative medicine. This in turn has increased demand for stem cells and their derivatives.

Based on End User, the market is segmented into Pharmaceutical and Biopharmaceutical Industries and Contract Research Organizations (CRO), and Other End Users. Out of which, Pharmaceutical and Biopharmaceutical Industries Segment is expected to dominate the global single-use bioreactor market over the forecast period and this is attributed to the rise in adoption of single-use bioreactors by these industries.

Global Single-Use Bioreactor Market: Key Developments

In April 2020, Celltainer Biotech BV planned to partner with PAN-Biotech, as a part of its strategic alliance to offer integrated solutions for cell culture processes.

In September 2019, Abec Inc. announced the launch of the single-use bioreactor with a volume of 6,000 L to deliver performance comparable to stainless steel systems.

Global Single-Use Bioreactor Market: Key Companies Insights

The global single-use bioreactor market is highly competitive. This is attributed to the increase in demand for single-use bioreactors across the globe, as a result, players in the market are focusing on launching novel products in the market.

Some of the key players in the global single-use bioreactor market are:

Sartorius AG, OmniBRx Biotechnologies, Merck KgaA, Solaris Biotechnology Srl, Eppendorf AG, Distek Inc., Celltainer Biotech BV, ABEC Inc., Thermo Fisher Scientific, and Danaher Corporation (Pall Corporation), among others.

*Definition: A single-use bioreactor (SUB) is a bioreactor with the disposable bag instead of a culture vessel. Single-use bioreactor can promote efficient ways for pharmaceutical companies to speed up and secure start-up and product development. Single-use bioreactors are emerging as a key technology in the field of pharmaceuticals.

Detailed Segmentation:

• Global Single-Use Bioreactor Market By Product:
  • Single-use Bioreactor Systems
  • Media Bags
  • Filtration Assemblies
  • Other Products
• Global Single-Use Bioreactor Market By Cell Type:
  • Mammalian Cell
  • Bacteria
  • Yeast
  • Other Cell Types
• Global Single-Use Bioreactor Market By Molecule Type:
  • Vaccines
  • Monoclonal Antibodies
  • Stem Cells
  • Recombinant Proteins
  • Other Molecule Types
• Global Single-Use Bioreactor Market By End User:
  • Pharmaceutical and Biopharmaceutical Industries
  • Contract Research Organizations (CRO)
  • Other End Users
• Global Single-Use Bioreactor Market By Geography:
  • North America
  • Europe
  • Asia-Pacific
  • Middle East and Africa
  • South America