PERIODIC FEVER MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2026-2033)

Periodic Fever Market, By Disease Type (Familial Mediterranean Fever, TNF Receptor–Associated Periodic Syndrome, Mevalonate Kinase Deficiency, Cryopyrin-Associated Periodic Syndromes, PFAPA Syndrome, and Systemic Autoinflammatory Periodic Fevers), By Treatment Type (Biologic Therapies, Corticosteroids, Colchicine Therapy, NSAIDs & Symptomatic Treatments, Immunosuppressants, and Emerging Targeted Therapies & Gene-based Treatments), By Route of Administration (Injectable, Oral, and Intravenous Infusion), By Diagnosis Type (Genetic Testing, Laboratory & Biomarker Testing, Clinical Diagnosis, and Imaging & Supportive Diagnostic Methods), By Patient Group (Pediatric Patients and Adult Patients), By End User (Hospitals, Specialty & Rheumatology Clinics, Ambulatory Surgical Centers, and Homecare Settings), By Distribution Channel (Online and Offline), By Geography (North America, Latin America, Europe, Asia Pacific, Middle East and Africa)

Published In: 04 Feb, 2026
Code: CMI9297
Pages: 152
Formats: Excel and PDF
Industry: Pharmaceutical
- Historical Range : 2020 - 2024
- Estimated Year : 2025
- Forecast Period : 2026-2033

According to Coherent Market Insights, the global periodic fever market is estimated to be valued at USD 724.6 Mn in 2026 and is expected to reach 1,006.07 Mn by 2033, exhibiting a compound annual growth rate (CAGR) of 4.8% from 2026 to 2033. The global periodic fever market encompasses a specialized segment of the rare disease therapeutics landscape, focusing on hereditary autoinflammatory syndromes characterized by recurrent episodes of fever and inflammation. These conditions, including Familial Mediterranean Fever (FMF), Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS), and Cryopyrin-Associated Periodic Syndromes (CAPS), represent a group of genetically inherited disorders affecting thousands of patients worldwide.

The market has witnessed significant advancement in recent years, driven by enhanced diagnostic capabilities, improved understanding of disease pathophysiology, and the development of targeted therapeutic interventions. Pharmaceutical companies and biotechnology firms are increasingly investing in research and development activities to address the substantial unmet medical needs within this patient population.

The market encompasses various treatment modalities, including anti-inflammatory agents, biologics, and novel targeted therapies designed to prevent or reduce the frequency and severity of periodic fever episodes. With growing awareness among healthcare professionals and improved diagnostic techniques, the market is experiencing steady expansion as more patients receive accurate diagnoses and appropriate treatment interventions, ultimately improving quality of life outcomes for individuals suffering from these debilitating autoinflammatory conditions.

Market Dynamics

The global periodic fever market is primarily driven by several compelling factors that continue to shape its growth trajectory and market penetration. The increasing prevalence and recognition of hereditary autoinflammatory syndromes worldwide serves as a fundamental growth driver, as healthcare systems become more sophisticated in diagnosing these previously under-recognized conditions through advanced genetic testing and biomarker identification technologies. The development of targeted biologics and precision medicine approaches has revolutionized treatment paradigms, offering patients more effective therapeutic options with improved safety profiles compared to traditional anti-inflammatory treatments.

Government initiatives and regulatory support for orphan drug development, including expedited approval pathways and market exclusivity incentives, have encouraged pharmaceutical investments in this niche therapeutic area. However, the market faces significant restraints including the extremely high costs associated with biologic therapies, which create accessibility barriers for patients and healthcare systems, particularly in developing economies. Limited disease awareness among primary care physicians often leads to delayed diagnoses and prolonged patient suffering, while the small patient populations inherent to rare diseases present commercial challenges for pharmaceutical companies seeking return on investment.

The complexity of these genetic disorders and variability in clinical presentations create additional diagnostic and treatment challenges. Nevertheless, substantial opportunities exist through expanding global healthcare infrastructure, increasing healthcare expenditure in emerging markets, and growing pharmaceutical industry focus on rare disease portfolios. The potential for combination therapies, personalized treatment approaches based on genetic profiling, and the development of next-generation therapeutics with improved efficacy and reduced side effect profiles represent significant market expansion opportunities that could transform patient outcomes and market dynamics.

Key Features of the Study

This report provides in-depth analysis of the global Periodic Fever market, and provides market size (USD Mn) and compound annual growth rate (CAGR%) for the forecast period (2026–2033), considering 2025 as the base year
It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, market trends, regional outlook, and competitive strategies adopted by key players
It profiles key players in the global periodic fever market based on the following parameters – company highlights, products portfolio, key highlights, financial performance, and strategies
Key companies covered as a part of this study include Novartis, Swedish Orphan Biovitrum Sobi, Regeneron Pharmaceuticals, Takeda Pharmaceutical Company, Hikma Pharmaceuticals, Amgen, Pfizer, AbbVie, Janssen Biotech Johnson and Johnson, Roche, Sanofi, UCB, Bristol Myers Squibb, Teva Pharmaceutical Industries, and Dr Reddys Laboratories
Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
The global periodic fever market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global periodic fever market

Market Segmentation

Disease Type Insights (Revenue, USD Mn, 2021 - 2033)
- Familial Mediterranean Fever
- TNF Receptor–Associated Periodic Syndrome
- Mevalonate Kinase Deficiency
- Cryopyrin-Associated Periodic Syndromes
- PFAPA Syndrome
- Systemic Autoinflammatory Periodic Fevers
Treatment Type Insights (Revenue, USD Mn, 2021 - 2033)
- Biologic Therapies
- Corticosteroids
- Colchicine Therapy
- NSAIDs & Symptomatic Treatments
- Immunosuppressants
- Emerging Targeted Therapies & Gene-based Treatments
Route of Administration Insights (Revenue, USD Mn, 2021 - 2033)
- Injectable
- Oral
- Intravenous Infusion
Diagnosis Type Insights (Revenue, USD Mn, 2021 - 2033)
- Genetic Testing
- Laboratory & Biomarker Testing
- Clinical Diagnosis
- Imaging & Supportive Diagnostic Methods
Patient Group Insights (Revenue, USD Mn, 2021 - 2033)
- Pediatric Patients
- Adult Patients
End User Insights (Revenue, USD Mn, 2021 - 2033)
- Hospitals
- Specialty & Rheumatology Clinics
- Ambulatory Surgical Centers
- Homecare Settings
Distribution Channel Insights (Revenue, USD Mn, 2021 - 2033)
- Online
- Offline
Regional Insights (Revenue, USD Mn, 2021 - 2033)
- North America
  - U.S.
  - Canada
- Latin America
  - Brazil
  - Argentina
  - Mexico
  - Rest of Latin America
- Europe
  - Germany
  - U.K.
  - Spain
  - France
  - Italy
  - Russia
  - Rest of Europe
- Asia Pacific
  - China
  - India
  - Japan
  - Australia
  - South Korea
  - ASEAN
  - Rest of Asia Pacific
- Middle East
  - GCC Countries
  - Israel
  - Rest of Middle East
- Africa
  - South Africa
  - North Africa
  - Central Africa
Key Players Insights
- Novartis
- Swedish Orphan Biovitrum Sobi
- Regeneron Pharmaceuticals
- Takeda Pharmaceutical Company
- Hikma Pharmaceuticals
- Amgen
- Pfizer
- AbbVie
- Janssen Biotech Johnson and Johnson
- Roche
- Sanofi
- UCB
- Bristol Myers Squibb
- Teva Pharmaceutical Industries
- Dr Reddys Laboratories

Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
Market Purview
- Report Description
  - Market Definition and Scope
- Executive Summary
  - Global Periodic Fever Market, By Disease Type
  - Global Periodic Fever Market, By Treatment Type
  - Global Periodic Fever Market, By Route of Administration
  - Global Periodic Fever Market, By Diagnosis Type
  - Global Periodic Fever Market, By Patient Group
  - Global Periodic Fever Market, By End User
  - Global Periodic Fever Market, By Distribution Channel
  - Global Periodic Fever Market, By Region
Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Impact Analysis
- Key Highlights
- Regulatory Scenario
- Product Launches/Approvals
- PEST Analysis
- PORTER’s Analysis
- Market Opportunities
- Regulatory Scenario
- Key Developments
- Industry Trends
Global Periodic Fever Market, By Disease Type, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Familial Mediterranean Fever
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- TNF Receptor–Associated Periodic Syndrome
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Mevalonate Kinase Deficiency
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Cryopyrin-Associated Periodic Syndromes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- PFAPA Syndrome
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Systemic Autoinflammatory Periodic Fevers
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Treatment Type, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Biologic Therapies
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Corticosteroids
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Colchicine Therapy
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- NSAIDs & Symptomatic Treatments
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Immunosuppressants
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Emerging Targeted Therapies & Gene-based Treatments
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Route of Administration, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Injectable
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Oral
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Intravenous Infusion
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Diagnosis Type, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Genetic Testing
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Laboratory & Biomarker Testing
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Clinical Diagnosis
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Imaging & Supportive Diagnostic Methods
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Patient Group, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Pediatric Patients
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Adult Patients
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By End User, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Hospitals
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Specialty & Rheumatology Clinics
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Ambulatory Surgical Centers
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Homecare Settings
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Distribution Channel, 2021-2033, (USD Mn)
- Introduction
  - Market Share Analysis, 2026 and 2033 (%)
  - Y-o-Y Growth Analysis, 2022 - 2033
  - Segment Trends
- Online
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
- Offline
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2021-2033, (USD Mn)
Global Periodic Fever Market, By Region, 2021 - 2033, Value (USD Mn)
- Introduction
  - Market Share (%) Analysis, 2026, 2029 & 2033, Value (USD Mn)
  - Market Y-o-Y Growth Analysis (%), 2022 - 2033, Value (USD Mn)
  - Regional Trends
- North America
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country, 2021 - 2033, Value (USD Mn)
    - U.S.
    - Canada
- Latin America
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country, 2021 - 2033, Value (USD Mn)
    - Brazil
    - Argentina
    - Mexico
    - Rest of Latin America
- Europe
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country, 2021 - 2033, Value (USD Mn)
    - Germany
    - U.K.
    - Spain
    - France
    - Italy
    - Russia
    - Rest of Europe
- Asia Pacific
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country, 2021 - 2033, Value (USD Mn)
    - China
    - India
    - Japan
    - Australia
    - South Korea
    - ASEAN
    - Rest of Asia Pacific
- Middle East
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country, 2021 - 2033, Value (USD Mn)
    - GCC Countries
    - Israel
    - Rest of Middle East
- Africa
  - Introduction
  - Market Size and Forecast, By Disease Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Treatment Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Route of Administration, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Diagnosis Type, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Patient Group, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By End User, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Distribution Channel, 2021 - 2033, Value (USD Mn)
  - Market Size and Forecast, By Country/Region, 2021 - 2033, Value (USD Mn)
    - South Africa
    - North Africa
    - Central Africa
Competitive Landscape
- Novartis
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Swedish Orphan Biovitrum Sobi
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Regeneron Pharmaceuticals
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Takeda Pharmaceutical Company
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Hikma Pharmaceuticals
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Amgen
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Pfizer
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- AbbVie
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Janssen Biotech Johnson and Johnson
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Roche
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Sanofi
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- UCB
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Bristol Myers Squibb
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Teva Pharmaceutical Industries
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Dr Reddys Laboratories
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
Analyst Recommendations
- Wheel of Fortune
- Analyst View
- Coherent Opportunity Map
References and Research Methodology
- References
- Research Methodology
- About us

*Browse 32 market data tables and 28 figures on 'Periodic Fever Market' - Global forecast to 2033

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