Cns specific antisense oligonucleotide market
CNS Specific Antisense Oligonucleotide Market - by Drug (Approved and Pipeline), by Indication (Hereditary transthyretin amyloidosis (hATTR)/ Polyneuropathy, Spinal Muscular Atrophy, and Huntington’s Disease), by Distribution Channel (Hospital Pharmacy, Retail Pharmacy, and Online Pharmacy), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2018 – 2026
- Feb 2019
- CMI2477
- 206 Pages
- Excel & Pdf
- Pharmaceutical
Global CNS Specific Antisense Oligonucleotide Market – Breakthrough Treatment for CNS Disorders
Antisense oligonucleotide plays a major role in modern healthcare, as it acts on the messenger RNA level before the protein is formed to inhibit expression of certain diseases-causing genes.
The global CNS specific antisense oligonucleotide market size was valued at US$ 883.7 million in 2017, and is expected to exhibit a CAGR of 24.9% over the forecast period (2018 – 2026).
Figure 1. Global CNS Specific Antisense Oligonucleotide Market Value (US$ Mn), by Region, 2017
Source: Coherent Market Insights Analysis (2019)
Increasing prevalence of cancer is expected to propel growth of the CNS specific antisense oligonucleotide market
CNS specific antisense oligonucleotide is used for treatment of neurodegenerative disorders and associated rare diseases. According to February 2017, report of National Center for Biotechnology Information (NCBI), an estimated the prevalence of Cerebral palsy ranges from 1.5 to more than 4 per 1,000 of children from age 10 to 14 years. The birth prevalence of Cerebral palsy is around 2 per 1,000 live births globally.
Furthermore, launch of new products for rare disease associated with CNS disorders is propelling growth of the CNS specific antisense oligonucleotide market over the forecast period. For instance, in October 2018, Ionis Pharmaceuticals, Inc. and Akcea Therapeutics, Inc. received the U.S. Food and Drug Administration (FDA) approval for its novel drug TEGSEDITM (inotersen) indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. In the same year, company received approval from Canadian Health authority for the novel drug TEGSEDITM (inotersen).
However, high cost of treatment and risk of toxicity is expected to hinder the market growth. According to the Journal Molecular Therapy, in May 2017, Biogen priced Spinraza (nusinersen injection) at US$ 750,000 for the first year’s treatment (US$125,000 per injection) and US$350,000 per year.
Figure 2. Global CNS Specific Antisense Oligonucleotide Market Share (%), by Drug, 2018 and 2026
Source: Coherent Market Insights Analysis (2019)
Government support for development and launch of antisense drugs in North America is expected to bolster the market growth
North America holds the dominant position in the global CNS specific antisense oligonucleotide market, owing to strong government support for antisense drugs. For instance, in March 2018, GeneTx Biotherapeutics LLC’s, GTX-101 received the U.S. Food and Drug Administration’s (FDA) orphan-drug designation for GTX-101 for the treatment of Angelman syndrome. It is a rare neurogenetic disorder that affects around one in 15,000 people, according to the FDA statement.
Increasing prevalence of Alzheimer disease in the region is also expected to boost the market growth. For instance, in August 2012, National Center for Biotechnology Information (NCBI) stated Alzheimer disease as the most frequent cause of dementia in Western societies and estimated around 5.5 million cases in the U.S. and the prevalence worldwide is estimated to be as high as 24 million.
Moreover, rich product pipeline for treatment of neurodegenerative disorders is expected to drive the market growth. For instance, in October 2017, Ionis Pharmaceuticals, Inc., initiated a Phase 1/2 clinical study of IONIS-MAPTRx in patients with mild Alzheimer's disease. Biogen funded US$ 10 million milestone payment to Ionis Pharmaceuticals, Inc.
Moreover, key players in the players are focused on receiving the U.S. Food and Drug Administration (FDA) approval for novel products to reduce the burden of CNS associated disorders. For instance, in September 2016, Sarepta Therapeutics received the U.S. Food and Drug Administration (FDA) approval for Exondys 51(eteplirsen) used for treatment of rare genetic disorder Duchenne muscular dystrophy.
Key Players
Major players operating in the global CNS specific antisense oligonucleotide market include Alnylam Pharmaceuticals Inc., Sarepta Therapeutics Inc., Biogen Inc., Ionis Pharmaceuticals Inc., Wave Life Sciences Ltd., Stroke Therapeutic Inc., Dynacure, ProQR Therapeutics N.V., and Q-STATE BIOSCIENCES, INC.
Table of Contents
- Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Drug
- Market Snippet, By Indication
- Market Snippet, By Distribution Channel
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Drivers
- Restraints
- Market Opportunities
- Impact Analysis
- Pipeline Analysis
- Reimbursement Scenario
- Epidemiology
- Pest Analysis
- Global CNS Specific Antisense Oligonucleotide Market, By Drug, 2018 – 2026, (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Approved
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Patisiran
- Nusinersen
- Inotersen
- Pipeline
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- IONIS-HTT Rx (RG6042)
- Global CNS Specific Antisense Oligonucleotide Market, By Indication, 2018 – 2026, (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Hereditary transthyretin amyloidosis (hATTR)/ Polyneuropathy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Spinal Muscular Atrophy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Huntington’s Disease
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Global CNS Specific Antisense Oligonucleotide Market, By Distribution Channel, 2018 – 2026, (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Hospital Pharmacy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Retail Pharmacy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Online Pharmacy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Global CNS Specific Antisense Oligonucleotide Market, By Region, 2018 – 2026, (US$ Mn)
- Introduction
- Market Share Analysis, By Region, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, For Regions, 2017–2026
- North America
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- U.S.
- Canada
- Latin America
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- Europe
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- Germany
- U.K.
- France
- Italy
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- China
- India
- Japan
- Australia
- South Korea
- ASEAN
- Rest of APAC
- Middle East
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- GCC
- Israel
- Rest of Middle East
- Africa
- Market Size and Forecast, By Drug, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Indication, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026, (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Mn)
- South Africa
- Central Africa
- North Africa
- Competitive Landscape
- Heat Map Analysis
- Company Profiles
- Alnylam Pharmaceuticals Inc.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Sarepta Therapeutics Inc.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Biogen Inc.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Ionis Pharmaceuticals Inc.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Wave Life Sciences Ltd.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Stroke Therapeutic Inc.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Dynacure
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- ProQR Therapeutics N.V.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Q-STATE BIOSCIENCES, INC.
- Company Overview
- Drug Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Analyst Views
- Section
- References
- Research Methodology
- About us and Sales Contact
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