Middle east and asia pacific cell and gene therapy market
Middle East and Asia Pacific Cell and Gene Therapy Market, by Therapy Type (Cell Therapy (Stem Cells, T Cells, Dendritic Cells, and NK Cells) and Gene Therapy (Germline Gene Therapy and Somatic Gene Therapy)), by Indication (Dermatology, Musculoskeletal, Oncology, Immunology, Cardiology & Neurology, and Others), by Technology (Lentiviral Vector, Plasmid DNA, and AAV), and by Region (Middle East and Asia Pacific) - Size, Share, Outlook, and Opportunity Analysis, 2022 - 2028
- Mar 2022
- CMI4981
- 425 Pages
- Excel & Pdf
- Biotechnology
Plasmid DNA is becoming increasingly important in clinical research for gene therapy and genetic vaccine applications. Good manufacturing practice (GMP)-grade plasmid DNA is required for direct gene transfer into humans. The same is true if the drug material contains a genetically modified cell, such as chimeric antigen receptor (CAR) T cells, which are employed along with the plasmids present in the drug substance.
In many circumstances, however, high quality grade plasmid DNA is approved as a starting material for GMP synthesis of mRNA or viral vectors (lentiviral vectors, adeno-associated virus vectors, and so on). AAV (adeno associated viruses) vectors support the production of protein, leading to therapeutic effect, without permanently altering the patient’s DNA. Lentiviral vectors are retroviruses used to introduce a functional copy of a gene to the patient’s extracted hematopoietic stem cells with a longer-term therapeutic effect.
Middle East and Asia Pacific cell and gene therapy market is estimated to be valued at US$ 2,616.8 million in 2021 and is expected to exhibit a CAGR of 17.3% over the forecast period (2021-2028).
Figure 1. Middle East and Asia Pacific Cell and Gene Therapy Market Share (%), in Terms of Value, By Region, 2021
Increasing launch and approval of novel gene therapies for the treatment of various rare diseases is expected to derive the market growth
In June 2017, Horama S.A. a biotechnology company announced that U.S. Food and Drug Administration (FDA) granted Orphan Drug Designation (ODD) to HORARLBP1. A gene replacement therapy Moreover, HORARLBP1 is developed for the treatment of retinitis punctata albescens and retinitis pigmentosa caused by mutations in the RLBP1 gene.
Middle East and Asia Pacific Cell and Gene Therapy Market Report Coverage
Report Coverage | Details | ||
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Base Year: | 2020 | Market Size in 2021: | US$ 2,616.8 Mn |
Historical Data for: | 2017 to 2020 | Forecast Period: | 2021 to 2028 |
Forecast Period 2021 to 2028 CAGR: | 17.3% | 2028 Value Projection: | US$ 8,015.1 Mn |
Geographies covered: |
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Segments covered: |
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Companies covered: |
Novartis International AG, Pfizer, Inc., Sanofi S.A., Amgen, Inc., Regeneron Pharmaceuticals, Inc., F. Hoffmann-La Roche AG, Bluebird Bio, Inc. (Celgene Corporation), Gene biotherapeutics, Sibiono GeneTech Co. Ltd., Kolon TissueGene, Inc., Horama S.A., MeiraGTx Limited, Gilead Sciences, Inc., Biogen INC., Organogenesis, Inc., JCR Pharmaceuticals Co. Ltd, uniQure N.V., WuxiAppTec, Lonza, and Immuneel Therapeutics Pvt Ltd |
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Growth Drivers: |
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Restraints & Challenges: |
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Figure 2. Middle East and Asia Pacific Cell and Gene Therapy Market Share (%), by Therapy Type, 2021
Middle East and Asia Pacific Cell and Gene Therapy Market – Impact of Coronavirus (COVID-19) Pandemic – Impact on Drug Development and Clinical Trials
While the healthcare industry continues to focus on the development of COVID-19 vaccines and therapies, the COVID-19 crisis had a significant impact on clinical trials in many therapy areas such as oncology, cardiovascular, and others.
Research programs and preclinical operations have been affected across the cell and gene therapies (CGTs) sector, as pharmaceutical businesses have restricted the number of individuals working on-site to keep them safe and comply with regulatory instructions.
The increasing demand for COVID-19-related laboratory consumables such as personal protective equipment and reagents has hampered the research and preclinical development, resulting in supply chain constriction.
Cell and gene therapies (CGTs) are at the forefront of medical advancements in the treatment of serious diseases such as cancer, cardiovascular diseases, and others. Many more CGTs are currently being developed.
Middle East and Asia Pacific Cell and Gene Therapy Market: Restraint
Factor such as unfavorable reimbursement policies for cell and gene therapy products is expected to hamper the market growth over the forecast period.
Kymriah is a genetically-modified autologous T-cell immunotherapy has listed price of US$ 475,000 for patients with acute lymphocytic leukemia and US$ 373,000 for patients with large B-cell lymphoma; whereas, Yescarta has a listed price of US$ 373,000. Indicated for the treatment of adults with follicular lymphoma or certain types of large B-cell lymphoma Therefore, treatment with such a high price requires government support, in terms of reimbursement policy for a better adoption rate.
However, cell and gene therapy has witnessed multiple setbacks from regulatory authorities in charge of reimbursement policies, which is expected to hinder growth of the market.
Key Players
Major players operating in the Middle East and Asia Pacific cell and gene therapy market include Novartis International AG, Pfizer, Inc., Sanofi S.A., Amgen, Inc., Regeneron Pharmaceuticals, Inc., F. Hoffmann-La Roche AG, Bluebird Bio, Inc. (Celgene Corporation), Gene biotherapeutics, Sibiono GeneTech Co. Ltd., Kolon TissueGene, Inc., Horama S.A., MeiraGTx Limited, Gilead Sciences, Inc., Biogen INC., Organogenesis, Inc., JCR Pharmaceuticals Co. Ltd, uniQure N.V., WuxiAppTec, Lonza, and Immuneel Therapeutics Pvt Ltd.
Table of Contents
- Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Therapy Type
- Market Snippet, By Indication
- Market Snippet, By Technology
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Report Description
- Market Dynamics, Regulations, and Trends Analysis
- Drivers
- Restraints
- Challenges in Cell and Gene Therapy
- Capital Intensive Process
- Opportunity
- Impact Analysis
- Adoptive T-cell’s Therapy Evolution
- Market Trends
- Regulatory Scenario
- Reimbursement Scenario
- Pipeline Analysis
- Partnership and Collaboration Scenario
- PEST Analysis
- PORTER’S Five Forces
- Epidemiology
- Company Market Share Analysis
- Drug Development Process For Cell And Gene Therapy
- Application of Plasmid DNA and Viral Vector in Cell and Gene Therapy
- Pre-clinical and Clinical Development Scenario for Cell and Gene Therapy
- Regulatory Pathway from Clinical Trials to Marketing Authorization
- List of Approved Cell and Gene Therapy Products
- List of Upcoming Cell and Gene Therapy Companies in ME and APAC Countries
- Middle East and Asia Pacific Cell and Gene Therapy Market – Impact of Coronavirus (Covid-19) Pandemic
- Economic Impact
- COVID-19 Epidemiology
- Impact on Drug Development and Clinical Trials
- Key Developments
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Therapy Type, 2017 – 2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2021 and 2028 (%)
- Y-o-Y Growth Analysis, 2018 – 2028
- Segment Trends
- Cell Therapy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Stem Cells
- T Cells
- Dendritic Cells
- NK Cells
- Gene Therapy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Germline Gene Therapy
- Somatic Gene Therapy
- Introduction
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Indication, 2017 – 2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2021 and 2028 (%)
- Y-o-Y Growth Analysis, 2018 – 2028
- Segment Trends
- Dermatology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Musculoskeletal
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Oncology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Immunology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Cardiology & Neurology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Introduction
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Technology, 2017 – 2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2021 and 2028 (%)
- Y-o-Y Growth Analysis, 2018 – 2028
- Segment Trends
- Lentiviral Vector
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Plasmid DNA
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- AAV
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017 – 2028, (US$ Mn)
- Introduction
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Region, 2017 – 2028, (US$ Mn)
- Introduction
- Market Share Analysis, By Region, 2021 and 2028 (%)
- Y-o-Y Growth Analysis, For Regions, 2018–2028
- Middle East
- Market Size and Forecast, By Therapy Type, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Indication, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Technology, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Country, 2017 – 2028, (US$ Mn)
- Kingdom of Saudi Arabia
- UAE
- Israel
- Iran
- Jordan
- Rest of Middle East
- Asia Pacific
- Market Size and Forecast, By Therapy Type, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Indication, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Technology, 2017 – 2028, (US$ Mn)
- Market Size and Forecast, By Country, 2017 – 2028, (US$ Mn)
- South East Asia
- Philippines
- Malaysia
- Singapore
- Thailand
- Vietnam
- Rest of South East Asia
- Taiwan
- Hong Kong
- Macau
- Japan
- South Korea
- India
- Australia
- China
- Rest Of Asia pacific
- South East Asia
- Introduction
- Competitive Landscape
- Competitive Snapshot
- Novartis International AG
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Pfizer, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Sanofi S.A.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Amgen, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Regeneron Pharmaceuticals, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Hoffmann-La Roche AG
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Bluebird Bio, Inc. (Celgene Corporation)
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Gene biotherapeutics
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Sibiono GeneTech Co. Ltd.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Kolon TissueGene, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Horama S.A.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- MeiraGTx Limited
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Gilead Sciences, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Biogen INC.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Organogenesis, Inc.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- JCR Pharmaceuticals Co. Ltd
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- uniQure N.V.
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- WuxiAppTec
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Lonza
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Immuneel Therapeutics Pvt Ltd
- Company Overview
- Product Portfolio
- Financial Overview
- Key Highlights
- Market Strategies
- Novartis International AG
- Competitive Snapshot
- Section
- References
- Research Methodology
- About us and Sales Contact
*Browse 20 market data tables and 26 figures on "Middle East and Asia Pacific Cell and Gene Therapy Market” – forecast to 2028
Detailed Segmentation:
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Therapy Type:
- Cell Therapy
- Stem Cells
- T Cells
- Dendritic Cells
- NK Cells
- Gene Therapy
- Germline Gene Therapy
- Somatic Gene Therapy
- Cell Therapy
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Indication:
- Dermatology
- Musculoskeletal
- Oncology
- Immunology
- Cardiology & Neurology
- Others
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Technology:
- Lentiviral Vector
- Plasmid DNA
- AAV
- Middle East and Asia Pacific Cell and Gene Therapy Market, By Region:
- Middle East
- By Therapy Type
- Cell Therapy
- Stem Cells
- T Cells
- Dendritic Cells
- NK Cells
- Gene Therapy
- Germline Gene Therapy
- Somatic Gene Therapy
- Cell Therapy
- By Indication
- Dermatology
- Musculoskeletal
- Oncology
- Immunology
- Cardiology & Neurology
- Others
- By Technology
- Lentiviral Vector
- Plasmid DNA
- AAV
- By Country
- Kingdom of Saudi Arabia
- UAE
- Israel
- Iran
- Jordan
- Rest of Middle East
- By Therapy Type
- Asia Pacific
- By Therapy Type
- Cell Therapy
- Stem Cells
- T Cells
- Dendritic Cells
- NK Cells
- Gene Therapy
- Germline Gene Therapy
- Somatic Gene Therapy
- Cell Therapy
- By Indication
- Dermatology
- Musculoskeletal
- Oncology
- Immunology
- Cardiology & Neurology
- Others
- By Technology
- Lentiviral Vector
- Plasmid DNA
- AAV
- By Country
- South East Asia
- Philippines
- Malaysia
- Singapore
- Thailand
- Vietnam
- Rest of South East Asia
- Taiwan
- Hong Kong
- Macau
- Japan
- South Korea
- India
- Australia
- China
- Rest Of Asia pacific
- South East Asia
- By Therapy Type
- Middle East