Plant based biologics market
Plant-based Biologics Market, by Product Type (Monoclonal Antibodies, Alpha Interferon, Glucocerebrosidase, Vaccines, and Others), by Source Type (Carrot, Tobacco Leaves, Rice Seeds, Alfalfa, and Others), by Disease Indication (Gaucher Disease, Tooth Decay, Hepatitis, Lymphoma, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2020 - 2027
- Nov 2020
- CMI2394
- 204 Pages
- Excel & Pdf
- Biotechnology
Rising demand for human biologics cannot be fulfilled by currently used mammalian cell culture production platforms, as these platforms are highly expensive and have limited scalability. However, recent developments in plant expression vectors, downstream processing, and glycoengineering have established plants as a superior alternative to biologics production. Plants not only offer the traditional benefits of proper eukaryotic protein modification, but also have the potential to develop biologics at a lower cost with high scalability. They increase the production of biologics at unprecedented speed and also helps in controlling potential pandemics such as covid-19, Ebola and others for better efficacy or safety.
Plant-based biologics is expected to be the next major commercial development in the field of biotechnology. Some of the advantages offered by plant-based biologics in terms of product safety, production scale and economy, ease of storage, and distribution cannot be fulfilled at same time by any other current commercial system. Plant-based biologics also provide the opportunity to supply low-cost drugs and vaccines to the emerging economies such as Argentina, Brazil, China, India, Indonesia, Mexico, and others.
Plant-based Biologics Market – Impact of Coronavirus (Covid-19) Pandemic
The rapid spread of Covid-19 infection has positively impacted the plant-based biologics market as it has increased the demand of plant-based vaccines for prevention of Covid-19 infection. Rapid development of novel diagnostics, therapeutics, and vaccines is needed to mitigate spread of the SARS-CoV-2 virus and prevent future reoccurrences. Moreover, establishment of safe, efficacious vaccine platforms will be critical to develop a stronger level of preparedness for future outbreaks. Multiple vaccine technology platforms are being employed by companies such as iBio Inc., PlantForm to address the COVID-19 pandemic. More traditional approaches are based on live or killed viruses, while newer solutions rely on recombinant DNA or messenger RNA (mRNA). AstraZeneca, Pfizer, Moderna, and CureVac, among many others, are progressing new vaccines at an accelerated pace, with some already in late-stage clinical trials with tens of thousands of participants.
The plant-based biologics market is estimated to be valued at US$ 19.4 million in 2020 and is expected to exhibit a CAGR of 3.4% during the forecast period (2020-2027).
Figure 1. Plant-based Biologics Market Share (%) Regional Analysis, 2027
Robust pipeline of plant-based biologics are expected to boost growth of the plant-based biologics market
Major players in the market have a number of biopharmaceuticals products in clinical trials, or products that are awaiting approval from regulatory authorities. Thus, the robust pipeline of biopharmaceutical products is expected to significantly drive growth of the global plant-based biologics market in near future. For instance, Protalix Biotherapeutics’s, a global plant based biologics drug manufacturing company one major plant-based drug candidates in their pipeline – Pegunigalsidase alfa is designed to be a plant cell culture-expressed and a chemically modified version of the recombinant alpha-Galactosidase-A protein. In clinical research, pegunigalsidase alfa has exhibited a favorable circulatory half-life with targeted enzyme activity in organs affected by Fabry disease. The product is in phase 3 clinical trial.
Furthermore, iBio, Inc. is a plant–based biologics manufacturing company, which manufactures monoclonal antibodies, antigens, bioinks, and other recombinant proteins using FastPharming technologies has three plant-based biologics, which are in preclinical stage. In terms of human disease, IBIO-100 targets fibrosis, a leading cause of organ failure worldwide. IBIO-200 is a virus-like particle (VLP) vaccine designed as a rapid medical countermeasure solution to the COVID-19 outbreak. IBIO-201 is a vaccine targeting COVID-19 using the patented LicKM platform. Hence, such product developments are expected to positively impact the global plant-based biologics market growth.
Plant-based Biologics Market Report Coverage
Report Coverage | Details | ||
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Base Year: | 2019 | Market Size in 2020: | Over US$ 19.4 Mn |
Historical Data for: | 2017 to 2019 | Forecast Period: | 2020 to 2027 |
Forecast Period 2020 to 2027 CAGR: | 3.4% | 2027 Value Projection: | Over US$ 24.9 Mn |
Geographies covered: |
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Segments covered: |
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Companies covered: |
Leaf Expression Systems, Zea Biosciences, Planet Biotechnology Inc., InVitria, PlantForm Corporation, IBIO, Inc., Mapp Biopharmaceutical, Inc., Pfizer Inc., Ventria Bioscience Inc., Medicago Inc., Eleva GmbH, Kentucky Bioprocessing, LLC, Solarvest Bioenergy Inc., and Byondis B.V. |
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Growth Drivers: |
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Restraints & Challenges: |
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Plant-based Biologics Market – Restraints
The stringent regulatory guidelines for the production of plant-based biologics is one of the major factors that is expected to restrain growth of the plant-based biologics market over the forecast period. Moreover, concerns regarding contamination and environmental risks is another factor that is expected to hinder growth of the market. For instance, ProdiGene, Inc. Texas, a U.S.-based company introduced large-scale production of transgenic maize that produces trypsin. However, the U.S. Department of Agriculture (USDA) discovered that plant remnants from a previous ProdiGene trial had contaminated a nearby conventional field. ProdiGene was fined US$ 250,000 and US$ 3 million to cover the cleanup operation of mishandling the field test. The punitive action forced ProdiGene into bankruptcy. This event represented a significant setback to the commercial use of plant molecular farming (PMF).
Plant-based Biologics Market – Regional Analysis
On the basis of region, the global plant-based biologics market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.
North America is expected to be the most lucrative region in the plant-based biologics market over the forecast period. This is owing to the presence of various private and government research organizations focused on R&D activities to develop plant-based biologics in this region. For instance, Fraunhofer Center for Molecular Biotechnology completed phase I clinical trials for the study of safety and immunogenicity of plant-derived recombinant protective antigen (Biological: PA83-FhCMB) for anthrax vaccine in healthy adults in the year 2015. Furthermore, key players in North America are focused on conducting clinical trials to develop plant-based biologics for the treatment of various chronic diseases, which is further expected to drive growth of the plant-based biologics market in this region.
In addition, Latin America plant-based biologics market is expected to witness significant growth during the forecast period, owing to launch and construction of manufacturing facilities for plant-based biologics. For instance, in June 2017, Brazil-based Axis Biotec Brasil announced the construction of tobacco leaves-based biopharmaceutical expression and manufacturing facility in Brazil for the development of biosimilar and protein and biobetter drugs for the Brazilian market.
Figure 2. Plant-based Biologics Market Value (US$ Mn) & Y-o-Y Growth (%), 2016-2027
Plant-based Biologics Market - Competitive Landscape
Key players operating in the global plant-based biologics market include Leaf Expression Systems, Zea Biosciences, Planet Biotechnology Inc., InVitria, PlantForm Corporation, IBIO, Inc., Mapp Biopharmaceutical, Inc., Pfizer Inc., Ventria Bioscience Inc., Medicago Inc., Eleva GmbH, Kentucky Bioprocessing, LLC, Solarvest Bioenergy Inc., and Byondis B.V.
Table of Contents
- Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
- Market Overview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Product Type
- Market Snippet, By Source Type
- Market Snippet, By Disease Indication
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Report Description
- Market Dynamics, Regulations, and Trends Analysis
- Drivers
- Restraints
- Market Opportunities
- Impact Analysis
- Market Trends
- Pipeline Analysis
- Regulatory Scenario
- Major Technology Platforms For Plant-based Biologic Drug Production
- PEST Analysis
- Government Support
- Impact of COVID-19 on Plant-based Biologics Market
- During-COVID 19 Market Situation
- Overall Impact On Countries
- New Developments
- Global Plant-based Biologics Market, By Product Type, 2016 – 2027, (US$ Million)
- Introduction
- Market Share Analysis, 2020 and 2027 (%)
- Y-o-Y Growth Analysis, 2017 – 2027
- Segment Trends
- Monoclonal Antibodies
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Alpha Interferon
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Glucocerebrosidase
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Vaccines
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Introduction
- Global Plant-based Biologics Market, By Source Type, 2016 – 2027, (US$ Million)
- Introduction
- Market Share Analysis, 2020 and 2027 (%)
- Y-o-Y Growth Analysis, 2017 – 2027
- Segment Trends
- Carrot
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Tobacco Leaves
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Rice Seeds
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Alfalfa
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Introduction
- Global Plant-based Biologics Market, By Disease Indication, 2016 – 2027, (US$ Million)
- Introduction
- Market Share Analysis, 2020 and 2027 (%)
- Y-o-Y Growth Analysis, 2017 – 2027
- Segment Trends
- Gaucher Disease
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Tooth Decay
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Hepatitis
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Lymphoma
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
- Introduction
- Global Plant-based Biologics Market, By Region, 2016 – 2027, (US$ Million)
- Introduction
- Market Share Analysis, By Region, 2020 and 2027 (%)
- Y-o-Y Growth Analysis, By Region, 2017 – 2027
- Regional Trends
- North America
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
- U.S.
- Canada
- Europe
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
- China
- Japan
- India
- ASEAN
- Australia
- South Korea
- Rest of Asia Pacific
- Latin America
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- Middle East
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
- GCC Countries
- Israel
- Rest of Middle East
- Africa
- Market Size and Forecast, By Product Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Source Type, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Disease Indication, 2016 – 2027, (US$ Million)
- Market Size and Forecast, By Country/Region, 2016 – 2027, (US$ Million)
- North Africa
- Central Africa
- South Africa
- Introduction
- Competitive Landscape
- Company Profiles
- Leaf Expression Systems
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Zea Biosciences
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Planet Biotechnology Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- InVitria
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- PlantForm Corporation
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- IBIO, Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Mapp Biopharmaceutical, Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Pfizer Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Ventria Bioscience Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Medicago Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Eleva GmbH
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Kentucky Bioprocessing, LLC
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Solarvest Bioenergy Inc.
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Byondis B.V
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Leaf Expression Systems
- Company Profiles
- Section
- References
- Research Methodology
- About us and Sales Contact
*Browse 35 market data tables and 26 figures on "Global Plant-based Biologics Market” - Forecast to 2027”