Biotechnology
The biotech industry comprises bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share of this sector. Advancements in biotechnology has enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Increasing scientific understanding, advanced tools and techniques has led to emergence of various personalized medicines that are now in research phase. According to a research conducted by Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.
Biotech sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and also in disease prevention.
Key Challenges
Biotech products have extensive usage in oncology and autoimmune disease treatments. However, the costs of these drugs are exorbitantly high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging, with increased concern for safety of the drug.
Also, there is lack of awareness about personalized medicine among most healthcare providers, which hinders its adoption. Clinical adoption of the biotech products is essential for its success. However, it entails a lot of scientific evidences and explanation to the prescribers in order to ensure its safety.
“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”
- Tufts Center for the Study of Drug Development
Opportunities
The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to increased demand for the same, with consumers willing to pay high prices for these as compared to other conventional products. Moreover, biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sales of over US$ 2 Bn. Certain drugs such as Humira have generated sales of over US$ 10 Bn. Thus, investing in biotech R&D has yielded better results than pharmaceutical drugs.
For generic players, biosimilars offers a very good growth opportunity, as governments in emerging economies are supporting such therapies as cost-effective alternatives to biotech products. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:
- Erbitux (cetuximab) - February 2016
- Rituxan (rituximab) - September 2016
- Herceptin (trastuzumab) - June 2019
- Avastin (bevacizumab) - July 2019
- Aranesp (darbepoetin alfa) - May 2024
- Enbrel (etanercept) - November 2028
Companies such as Teva Pharmaceuticals, Hospira, Sandoz and Amgen are focusing their resources ondevelopment of biosimilars. Also, vaccines are other major products in development to focus on prevention aspect rather than just treatment. For instance, 2015 marked the U.S. launch of Zarxio TM, the first biosimilar approved in this market and the EMA approval of Mosquirix, the malaria vaccine. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.
Conclusion
Increasing research in biotech sector, in turn would translate into higher number of biopharma products seeking FDA approvals in future. Biopharma is positioned to be a promising treatment solution that would improve treatment outcomes and serve to accelerate and help reduce cost of drug development.
Published Date : Feb 2019
Global Cell and Gene Therapy Market – Rich Product Pipeline Cell and gene therapy plays a major role in modern healthcare, as they provide concepts and techniques that can be used in gene regulation, ce
Published Date : Jan 2019
Stem Cell Cartilage Regeneration Market – Insights Stem cells therapy are emerging as an important therapeutic option in the field of cartilage regeneration. Rapid development of stem cell-based therapy
Published Date : Jan 2019
Monoclonal Antibody Therapeutics Market - Insights Monoclonal antibodies are a type of immunotherapy, which are made in a laboratory and are several copies of a single antibody. Several monoclonal antibodies
Published Date : Dec 2018
Protein Expression Systems Market – Insights Protein expression has become an important laboratory technology in biochemistry, molecular biology, and protein research as well as other scientific researc
Published Date : Nov 2018
Gene Therapy for Rare Disease Market - Insights Gene therapy involves insertion of genetic material into cells of the patients to provide new function or to restore missing or inappropriate functioning
Published Date : Nov 2018
Pneumococcal Vaccines Market Insights Pneumococcal vaccine is used to prevent infection caused by streptococcus pneumoniae bacteria. There are two types of pneumococcal vaccines: pneumococcal conjugate vaccin
Published Date : Oct 2018
Tissue Engineering Market – Insights Tissue engineering is an interdisciplinary field addressed to develop functional three-dimensional tissues combining cells, scaffolds, and bioactive molecules. This
Published Date : Jul 2018
Recombinant Therapeutic Antibodies and Proteins Market– A Novel Approach to Treat Rare and Chronic Diseases Therapeutic proteins are engineered in the laboratory for pharmaceutical use, including non-co
Published Date : Jun 2018
Global Human Recombinant Insulin Market – Industry Insights Discovery of insulin is considered to be one of the most important events in the history of the diabetes treatment. Furthermore, major advance
Published Date : May 2018
Pediatric Vaccines Market – Insights Pediatric vaccines perform significant role in reduction of various childhood infectious disease such as measles, diphtheria, Poliomyelitis, and Haemophilus infl
Published Date : May 2018
Influenza Vaccines Market Insights – To Stop the Flu Is All Up to You Influenza is a contagious respiratory infection caused due to influenza virus. Influenza is marked by fever, cough, muscles and joi
Published Date : Apr 2018
Biomarkers Market - Global Industry Insights Biomarkers are the molecules used for diagnosis of diseases as these indicate normal or abnormal process in the body. Biomarkers can be any molecules such as DNA (
Published Date : Feb 2019
Immune Repertoire Sequencing Market – Insights Immune repertoire sequencing is extensively used in biomarker discovery to improve the success rate and cost-effectiveness of rational drug development. Fo
Published Date : Apr 2018
Recombinant Protein Market - Insights Recombinant proteins are used in development of novel therapies for severe chronic diseases such as cancer and other rare diseases. Recombinant protein production require
Published Date : Apr 2018
Wound Care Biologics Market – Experience the Power of Effective Healing Wound care biologics are bioengineered products used for non-healing wounds of the lower extremity. Demand for wound care bi
Published Date : Feb 2018
Stem Cell Banking Market – Assurance for a Lifetime Stem cells are building blocks of the immune system and blood, and they have the ability to develop into other cell types, in order to help in repairi
Published Date : Apr 2018
Genome Engineering Market- Insights Genome engineering is a process of insertion, deletion, modification or replacement of DNA bases in an organism. There are two types of gene therapy, Ex-Vivo Gene Therapy a
Published Date : Jan 2019
Anti-venom Market- Insights Anti-venom is a medicine used in the treatment of bite from venomous animals including snake, scorpion, spider, jellyfish, stone fish and others. Anti-venoms are sub-categorized in
To Be Published : Feb 2019
Proteomics is a study of large scale proteomes. Proteomes are entire complements of protein expressed by a tissue, cell or organism. Proteomics aims to interpret the roles of large number of proteins made from combining 22 genetically-encoded amino acids. It helps to
To Be Published : Feb 2019
Tissue plasminogen activator (tPA) is an enzyme associated with the disintegration of blood clots. It is a serine protease present in endothelial cells. With the help of serine protease, the conversion of plasminogen to&nbs
To Be Published : Feb 2019
Bovine blood plasma derivatives are products containing proteins that are obtained from the blood plasma of bovine animals using physico-chemical or other fractionation processes. Bovine blood plasma include, Factor VIII and IX Concentrate, Anti-Inhibitor Coagulation
To Be Published : Feb 2019
High quality DNA and RNA are important for a wide variety of research and clinical applications. Purification or isolation of nucleic acids is the first step in most molecular biological studies and in all recombinant DNA techniques. The extraction of nucleic aci
To Be Published : Feb 2019
Rising demand for human biologics cannot be fulfilled by currently used mammalian cell culture production platforms, as these platforms are highly expensive and have limited scalability. However, recent developments in plant expression vectors, downstream processing,
To Be Published : Feb 2019
Clostridium difficile infections are the most widely recognized cause of hospital acquired infectious diarrhea. There is a critical need for development of prevention vaccine for this disease. Clostridium difficile, is a gram-positive bacterium, whic
To Be Published : Feb 2019
Adipose derived stem cells (ADSCs) are stem cells derived from adipocytes, and can differentiate into variety of cell types. ADSCs have multipotency similar to bone marrow mesenchymal stem cells, thus ADSCs substitute for bone marrow as a source of stem cells. Numerou
To Be Published : Feb 2019
Nerve biologic products include artificial nerve conduit, nerve graft, nerve wraps, or nerve capping devices used for guiding axonal regrowth to facilitate nerve regeneration. These devices are majorly used in clinical treatments for nerve injuries. Nerve biologic pro
To Be Published : Feb 2019
Endostatin is a protein located in most Basement Membranes (BMs) in the body such as vascular basement membranes. A number of clinical studies have validated the significant survival benefits of recombinant human endostatin in treating late stage Non-Small-Cell Lung C
To Be Published : Feb 2019
Single cell genome sequencing involves isolating a single cell and amplifying and sequencing genes within that single cell. Sequencing single cell carries significant importance as individual cells can differ at great extent in size, protein levels, and expressed RNA
To Be Published : Feb 2019
Antibodies are common and essential research tools for various applications, including enzyme-linked immunosorbant assay (ELISA), flow cytometric analysis, immunoprecipitation, immunocytochemistry, immunohistochemistry, and western blotting. Monoclonal antibodies (MAb
To Be Published : Feb 2019
Non-insulin therapies are mostly used in type 2 diabetes patients, where body either does not produce enough insulin or is unable to effectively use the insulin it produces. Non-insulin-based medication works with different mechanism of action to reduce blood glucose
To Be Published : Feb 2019
Mononucleosis also known as mono or kissing disease is an infectious illness caused by Epstein-Barr virus. This virus is generally spread through saliva hence, commonly called as kissing disease. It can also be spread through other ways such as sharing drinks or utensils. Epstein-Barr vir
To Be Published : Feb 2019
A biological preparation that is used to provide active acquired immunity to a particular disease are called as vaccines. Vaccines are commonly of four types: live-attenuated vaccines, toxoid vaccines, subunit vaccines, and inactivated vaccines. Inactivated vaccines a
To Be Published : Feb 2019
Adjuvant is an integral part of a vaccine that helps to develop strong immune response in the human body. Conventional vaccines are derived from toxin, inactivated whole organism, and live-attenuated, which are effective in stimulating anti
To Be Published : Feb 2019
Hemodialysis is one among the three renal replacement therapies used for extracorporeal separation of waste components from the blood in case of kidney failure. Hemodialysis access, also known as vascular access
To Be Published : Feb 2019
Genes are composed of deoxyribonucleic acid (DNA), which contains essential information for producing proteins that are crucial for the optimal functioning of the body. Genetic disorder is the result of gene mutations in which proteins
To Be Published : Feb 2019
Epigenetics is the structural changes in chromosomal regions, which signal or perpetuate alteration in gene expression by turning it on or off. Epigenetic alteration includes DNA methylation, histone modification, chromatin remodeling, genomic imprinting, X chromosome
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