Biotechnology
The biotech industry comprises bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share of this sector. Advancements in biotechnology has enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Increasing scientific understanding, advanced tools and techniques has led to emergence of various personalized medicines that are now in research phase. According to a research conducted by Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.
Biotech sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and also in disease prevention.
Key Challenges
Biotech products have extensive usage in oncology and autoimmune disease treatments. However, the costs of these drugs are exorbitantly high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging, with increased concern for safety of the drug.
Also, there is lack of awareness about personalized medicine among most healthcare providers, which hinders its adoption. Clinical adoption of the biotech products is essential for its success. However, it entails a lot of scientific evidences and explanation to the prescribers in order to ensure its safety.
“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”
- Tufts Center for the Study of Drug Development
Opportunities
The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to increased demand for the same, with consumers willing to pay high prices for these as compared to other conventional products. Moreover, biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sales of over US$ 2 Bn. Certain drugs such as Humira have generated sales of over US$ 10 Bn. Thus, investing in biotech R&D has yielded better results than pharmaceutical drugs.
For generic players, biosimilars offers a very good growth opportunity, as governments in emerging economies are supporting such therapies as cost-effective alternatives to biotech products. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:
- Erbitux (cetuximab) - February 2016
- Rituxan (rituximab) - September 2016
- Herceptin (trastuzumab) - June 2019
- Avastin (bevacizumab) - July 2019
- Aranesp (darbepoetin alfa) - May 2024
- Enbrel (etanercept) - November 2028
Companies such as Teva Pharmaceuticals, Hospira, Sandoz and Amgen are focusing their resources ondevelopment of biosimilars. Also, vaccines are other major products in development to focus on prevention aspect rather than just treatment. For instance, 2015 marked the U.S. launch of Zarxio TM, the first biosimilar approved in this market and the EMA approval of Mosquirix, the malaria vaccine. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.
Conclusion
Increasing research in biotech sector, in turn would translate into higher number of biopharma products seeking FDA approvals in future. Biopharma is positioned to be a promising treatment solution that would improve treatment outcomes and serve to accelerate and help reduce cost of drug development.
Published Date : Apr 2018
Recombinant Protein Market - Insights Recombinant proteins are used in development of novel therapies for severe chronic diseases such as cancer and other rare diseases. Recombinant protein production require
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Wound Care Biologics Market – Experience the Power of Effective Healing Wound care biologics are bioengineered products used for non-healing wounds of the lower extremity. Demand for wound care bi
Published Date : Feb 2018
Stem Cell Banking Market – Assurance for a Lifetime Stem cells are building blocks of the immune system and blood, and they have the ability to develop into other cell types, in order to help in repairi
Published Date : Apr 2018
Genome Engineering Market- Insights Genome engineering is a process of insertion, deletion, modification or replacement of DNA bases in an organism. There are two types of gene therapy, Ex-Vivo Gene Therapy a
Published Date : Jan 2018
Dental Bone Graft and Substitutes Market Insights Dental bone grafts are used as fillers or scaffolds that facilitate bone formation and helps in the wound healing and are suitable for a variety of clinical p
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Flow Cytometry – It’s not just for immunologist anymore Flow cytometry is a widely used method for analyzing the expression of cell surface and intracellular molecules. It can also characterize a
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Pharmacogenomics Market: New Innovative Solution for Diverse Medical Applications Pharmacogenomics deals with the influence of genetic variation on drug response in patients by correlating gene expression cha
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Industrial Microbiology–Solving Big Issues with Micro Size/Microbial Revolution Industrial Microbiology involves commercial use of micro-organisms in various industrial processes such as fermentation.
Published Date : May 2017
Forensic Technologies and Services: Revolutionizing Crime Solving Advanced technologies in forensics science have been of substantial importance in recent years. Few examples of such advancements include enha
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Personalized Cell Therapy – Personalizing Treatment for Improved Outcomes Individualized treatment for various diseases such as cancer and autoimmune diseases by injecting living cells into a patient&rs
Published Date : Oct 2017
B-Cell Maturation Antigen (BCMA) Targeted Therapy – An innovative therapy for Multiple Myeloma Multiple myeloma (MM) refers to a clonal plasma cell malignant neoplasm that is observed in the soft, spon
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Cell Culture – Increased Production of Seasonal Influenza Vaccines Cell culture is fast emerging as an important tool for diagnosing and clinically treating various disease such as cancer and Alzheimer&
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CAR T Cell Therapy Market – A Revolution in Cancer Treatment Over the last few years, CAR T Cell therapy has gained wide recognition in the healthcare industry. CAR T cell is an innovative technique tha
Published Date : Mar 2017
Artificial Pancreas Device System (APDS) – Putting the Ease in Diabetes Management Administering insulin on daily basis is cumbersome for type 1 diabetes (T1D) patients in a busy lifestyle. While device
Published Date : Mar 2017
Tooth Regeneration Global dental industry has undergone a drastic transformation over the last decade. Teeth are among the most important part of human beings, which helps in performing various activities ran
To Be Published : May 2018
Low Molecular Weight Heparins (LMWH) are a form of pharmacological anticoagulant intervention. Low molecular weight heparin is used for prophylaxis of deep vein thrombosis and pulmonary embolism, or thrombosis occurring in a broad spectrum of clinical indications, inc
To Be Published : May 2018
Diabetes is one of most prevalent chronic diseases worldwide. According to WHO (World Health Organization), diabetes was one of top three leading causes of mortality in 2012. The diabetes vaccine currently under development has significant potential in younger age gro
To Be Published : May 2018
Ebola virus disease (EVD) causes viral hemorrhagic fever. It is a life threatening disease, which is spread to humans from animals. Direct contact with body fluids of infected person is one of largest causes of spread of this infection. Symptoms of Ebola disease inclu
To Be Published : May 2018
Orthobiologics are substances used to heal injuries such as fractures and injured muscles, ligaments, and tendons within a short period of time. Orthobiologics are made from substances that naturally occur in the body. Some examples of orthobiologics are bone grafts,
To Be Published : May 2018
Biosimilar is a biological product that resembles a reference product and is not difference from the already approved reference product. These are relatively cheaper than branded or approved products. Several biologics for oncology have already lost their patents, and
To Be Published : May 2018
Cell banking is a process of replicating and storing cells for the purpose of future use. Storage of these cell samples can be utilized for research purposes and for surgical reconstruction of damaged body structures. Cells are frozen in cryovials at -196 degrees Cels
To Be Published : May 2018
Blood clotting factors are proteins or enzymes that control bleeding. Blood clotting or blood coagulation is a process in which blood gets converted into solid clots at time of any wound or break down of blood vessels. Clotting can prevent death from bleeding and also
To Be Published : May 2018
Cell expansion is the large scale artificial production of daughter cells from a single cell, to support medical research. Rising preference for regenerative medicines offering faster results, and emergence of cell-based therapies with high patient compatibility are e
To Be Published : May 2018
Hematopoietic stem cell transplantation is a procedure in which multipotent hematopoietic stem cells sourced from peripheral blood cells, bone marrow or umbilical cord blood are transplanted into a patient. Hematopoietic stem cell transplantation is commonly used in t
To Be Published : May 2018
Anti-venom is a medication majorly used to treat snake bites and it can also be used to treat bites from scorpions, spiders or other reptiles. It is made by fractionating the blood of the donor (horse or sheep), which is hyper immunized with snake venom. These product
To Be Published : May 2018
Cancer is the second leading cause of morbidity and mortality worldwide. Major cause of cancer is gene mutation and rarely due to inherited genes. On the basis of the type of cell it initiates to form cancerous with, it is divided into carcinoma, lymphomas, leukaemias
To Be Published : May 2018
Shigella is a gram-negative pathogenic enterobacteria that causes severe diarrhea and dysentery in humans. Symptoms associated with Shigella infection includes fever, stomach pain, tenesmus, watery diarrhea, vomiting, dehydration, and convulsions. Various strains of S
To Be Published : May 2018
Advanced Therapy Medicinal Products (ATMPs) are innovative therapies that comprises cell therapy, gene therapy, and tissue engineered products. Cell therapy products include cellular immunotherapies and autologous and allogeneic cells for certain therapeutic indicatio
To Be Published : May 2018
Contract manufacturing organizations (CMOs) provide wide range of manufacturing services, which include contract packaging, quality testing, and development service to pharmaceutical and biotechnology industries. Biopharmaceutical companies prefer CMOs due to complexi
To Be Published : May 2018
Oral biologics represent a novel category of drugs, which is gaining traction in the last few decades. Biologic therapeutics has proven to be a highly effective treatment for various chronic ailments, such as diabetes, plaque psoriasis, arthritis, plaque psoriasis, Cr
To Be Published : May 2018
Gene therapy and genetically modified therapies are promising treatment option, which includes introduction of a normal or functional copy of a gene in the defective cell. Gene therapy has capability to cure or prevent the progression of diseases, which include inheri
To Be Published : May 2018
According to the study published in the Journal of Cancer Biology and Therapy, 2013, the controversial discovery of the 20th century by Otto Warburg led to study of metabolic activity in cancerous tissue, which increases the amount of production of lactate
To Be Published : May 2018
Platelet rich plasma (PRP) is a portion of the plasma fraction of analogous blood, which contains platelet concentration more than standard concentration. Platelets contains bio proteins that helps in healing, tissue regeneration, and blood loss. Platelet rich plasma
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