The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.
The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.
Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.
Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.
“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”
The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.
Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:
Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.
The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.
T-cell lymphoma is a type of blood cancer which arises from unregulated growth and multiplication of T-cell lymphocytes present in the immune system of the human body. T-cell lymphoma is of two major types: peripheral T-cell lymphoma and T-cell lymphoblastic lymphoma.... Read more
Ataxia is a group of degenerative disorders associated with the cerebellum in the brain, which is responsible for regulating balance and coordination of the body. Ataxia does not have a cure and only its symptoms such as weakness, difficulty in movement and others can... Read more
Bovine serum albumin (BSA or "Fraction V") is a serum albumin protein, which is extracted from blood plasma of cows. BSA is available in various forms such as powder or liquid for use in immunology, biochemistry and immunology related researchers. BSA’s immunoas... Read more
COVID-19 (Coronavirus Disease) is caused by the novel coronavirus SARS-CoV-2, which is a RNA virus. Few of the common symptoms of COVID-19 include fever, dry cough, fatigue, and body ache. COVID-19 disease can be transmitted from one person to another by the inhalatio... Read more
Insulin is a peptide hormone required in the body for normal carbohydrate, protein, and fat metabolism. Insulin is produced in the pancreas by the beta cells in specialized areas of pancreas called islets of Langerhans. Insulin promotes glucose uptake in the body cell... Read more
Cytology can be defined as the microscopic study of cell sample, which can be collected from any part of the body such as lungs, vagina, kidney, and others to assess the presence of irregular growth or lumps on the body surface. Cytology can also be used to assess abn... Read more
Neurological biomarkers are detectable substances majorly found in the cerebrospinal (CSF) fluid when there has been some damage to the brain. These biomarkers help in early diagnosis of neurological disorders, drug development, and for developing personalized medicin... Read more
Plant phenotyping refers to a set of methods and tools used to measure plant characteristics or phenotypes such as height, color, etc. Phenotypes are affected by environmental factors and interactions between genes. The knowledge of phenotypic characteristics of a pla... Read more
Genomic biomarkers are indicators based on gene expression, gene mutation, gene regulation, and other gene characteristics that can be measured for clinical diagnosis. Genomic biomarkers can be used to detect neurological, oncological, and cardiovascular diseases. Gen... Read more
Cardiac markers are used for the diagnosis and risk stratification of patients with chest pain and suspected acute coronary syndrome (ACS) and for management and prognosis in patients with acute heart failure, pulmonary embolism, and other disease states. ... Read more
Antifreeze proteins are capable of binding to ice by the phenomenon of adsorption and stopping the growth of ice crystals. This special property of antifreeze proteins finds its use in a variety of applications such as in food & beverage industry, medical industry... Read more
Blood and blood components are clinically used for blood transfusion to provide life-saving intervention to patient suffering from bleeding disorders, traumatic surgery, chronic diseases or rare blood diseases. Some of the bleeding disorders, which require blood trans... Read more
COVID-19 infection is caused by the novel SARS-CoV-2, which is a member of single stranded RNA coronavirus family. Few of the common symptoms observed in COVID-19 patients include dry cough, fever, and fatigue while some less common symptoms include muscle pain, nause... Read more
Gene panel test is a genetic testing tool which sequences the whole genome of the patient suspected to be suffering from diseases caused due to genetic mutations or are genetically inherited such as cancer, cardiovascular diseases, and others. Few applications of gene... Read more
Amniotic membrane is the innermost layer of fetal membrane which is extracted from placenta of women and harvested to be used as a transplant material for reconstructive surgery for cases such as severely burnt skin, trauma wounds, chronic wounds and others. Amniotic ... Read more
Industrial microbiology uses different microorganisms such as naturally occurring organisms, laboratory selected mutants, or even genetically modified organisms to produce a large variety of industrial products in large quantities. Industrial microbiology is a branch ... Read more
Biologics or biological products are medicines made from living organisms through highly complex manufacturing processes, and must be handled and administered under carefully monitored conditions. Biologics include a wide variety of products such as gene and cell ther... Read more
Chronic diseases often lead to catastrophic damage to vital organs. This damage is usually irreversible and leads to lifetime dependency on medicines. Under such severe conditions, transplants remain the component for restoration of healthy life. ... Read more