The biotech industry comprises bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share of this sector. Advancements in biotechnology has enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Increasing scientific understanding, advanced tools and techniques has led to emergence of various personalized medicines that are now in research phase. According to a research conducted by Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.
Biotech sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and also in disease prevention.
Key Challenges
Biotech products have extensive usage in oncology and autoimmune disease treatments. However, the costs of these drugs are exorbitantly high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging, with increased concern for safety of the drug.
Also, there is lack of awareness about personalized medicine among most healthcare providers, which hinders its adoption. Clinical adoption of the biotech products is essential for its success. However, it entails a lot of scientific evidences and explanation to the prescribers in order to ensure its safety.
“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”
Opportunities
The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to increased demand for the same, with consumers willing to pay high prices for these as compared to other conventional products. Moreover, biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sales of over US$ 2 Bn. Certain drugs such as Humira have generated sales of over US$ 10 Bn. Thus, investing in biotech R&D has yielded better results than pharmaceutical drugs.
For generic players, biosimilars offers a very good growth opportunity, as governments in emerging economies are supporting such therapies as cost-effective alternatives to biotech products. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:
Companies such as Teva Pharmaceuticals, Hospira, Sandoz and Amgen are focusing their resources ondevelopment of biosimilars. Also, vaccines are other major products in development to focus on prevention aspect rather than just treatment. For instance, 2015 marked the U.S. launch of Zarxio TM, the first biosimilar approved in this market and the EMA approval of Mosquirix, the malaria vaccine. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.
Conclusion
Increasing research in biotech sector, in turn would translate into higher number of biopharma products seeking FDA approvals in future. Biopharma is positioned to be a promising treatment solution that would improve treatment outcomes and serve to accelerate and help reduce cost of drug development.
Published Date : Apr 2018
Genome Engineering Market- Insights Genome engineering is a process of insertion, deletion, modification or replacement of DNA bases in an organism. There are two types of gene therapy, Ex-Vivo Gene Therapy a
Published Date : Jan 2019
Anti-venom Market- Insights Anti-venom is a medicine used in the treatment of bite from venomous animals including snake, scorpion, spider, jellyfish, stone fish and others. Anti-venoms are sub-categorized in
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Dental Bone Graft and Substitutes Market Insights Dental bone grafts are used as fillers or scaffolds that facilitate bone formation and helps in the wound healing and are suitable for a variety of clinical p
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Flow Cytometry – It’s not just for immunologist anymore Flow cytometry is a laser- or impedance-based, biophysical technology employed in cell counting, cell sorting, biomarker detection and prot
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Biochips Market - Insights Biochips are miniaturized laboratories, which can perform simultaneous biochemical reactions. On the basis of functionality, biochips are classified as DNA chips, protein chips, lab
Published Date : Jun 2018
Cell Free Protein Expression Market – Insights Cell free protein expression is al
Published Date : Jun 2018
Global Pharmacogenomics Market - Insights Pharmacogenomics deals with the influence of genetic variation on drug response in patients by correlating gene expression changes and Single-Nucleotide Polymorphisms
Published Date : Jun 2019
Global Oral Biologics Market Insights Biologics drugs can be defined as molecules derived from living cells such as microorganism or plant or animal cells and used for the treatment, diagnosis, or prevention of various diseases. Biologic
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Industrial Microbiology–Solving Big Issues with Micro Size/Microbial Revolution Industrial Microbiology involves commercial use of micro-organisms in various industrial processes such as fermentation.
Published Date : Feb 2019
Global Viral Vector and Plasmid DNA Manufacturing Market – Novel Approach for Disease Management Viral vector and plasmid DNA manufacturing plays a major role in modern healthcare, as it reduces disease
Published Date : Apr 2018
Recombinant DNA Technology Market – Power of Genetic Engineering in Improving Lives Recombinant DNA (rDNA) technology is a novel technique which have led to the advances in a number of different fields
Published Date : Apr 2019
Biosimilars Market – Insights Biosimilar products are suspected to continue to have a significant impact on the pharmaceutical industry. Many regulatory bodies have established clinical guidelines to su
Published Date : Apr 2018
Cell Lysis Market – Insights Cell lysis is the first step of protein extraction, which is further used for different application such as enzyme engineering and protein labelling. Furthermore, cell lysis
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Forensic Technologies and Services: Revolutionizing Crime Solving Advanced technologies in forensics science have been of substantial importance in recent years. Few examples of such advancements include enha
Published Date : Nov 2019
Personalized Cell Therapy Market - Insights Individualized treatment for various diseases such as cancer and autoimmune diseases by injecting living cells into a patient’s body is known as personalized cell th
Published Date : Oct 2017
B-Cell Maturation Antigen (BCMA) Targeted Therapy – An innovative therapy for multiple myeloma Multiple myeloma (MM) refers to a clonal plasma cell malignant neoplasm that is observed in the soft, spong
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Global Human Microbiome Market – Rich Product Pipeline Human microbiome play a major role in modern healthcare, as it allows easy digestion of food, regulation of immune system, and production of vitami
Published Date : Apr 2018
Cancer Biomarkers Market – Insights Cancer biomarkers are biological molecule produced either by tumor cells or by human tissues in response to cancer, which then measured and evaluated as an indicator
To Be Published : Dec 2019
Adenovirus is one of the DNA viruses that are considered to be a major cause of febrile illness, primarily among children. Individuals and Infants with weak immune systems, cardiac disease or chronic respiratory problems are at higher risk of developing adenovirus inf
To Be Published : Dec 2019
Nucleic acid testing (NAT) or nucleic acid amplification test (NAAT) is one of the advanced diagnostic test increasingly gaining traction over conventional culture methods, owing to high efficiency and accuracy. Furthermore, nucleic acid testing has potential applicat
To Be Published : Dec 2019
Peptide cancer vaccines aid to elicit and expand tumor-specific T-cells capable of controlling or eradicating tumor. The vaccine consists of one or more short or long amino acid sequences as tumor antigens, combined with vaccine adjuvant. In the recent past, results o
To Be Published : Dec 2019
Stem cells are basic form of biological cells, which can differentiate into other types of cells and can produce more of the same type of stem cells. There are two types of stem cells, which include embryonic stem cells, and adult stem cells. These cells are present i
To Be Published : Dec 2019
Vascular Endothelial Growth Factor (VEGF) is a signal protein that helps in the formation of new blood vessels through a process known as angiogenesis. Vascular endothelial growth factor is a part of several pathological processes and researches are often carried
To Be Published : Dec 2019
Lyme disease occurs due to bacterium Borrelia burgdorferi (Bb) and is transmitted to humans through the bite of infected blacklegged ticks. Its general symptoms include fatigue, headache, fever and a skin rash called erythema migrans. The infection can spread to heart
To Be Published : Dec 2019
Influenza is contagious respiratory disease that is caused by influenza viruses and can lead to hospitalization and even death in certain severe cases. Influenza virus infect the respiratory tract (nose, throat, and lungs) in humans. Seasonal influenza detected year-r
To Be Published : Dec 2019
Tuberculosis (TB) is a highly contagious disease caused by the bacterium known as Mycobacterium tuberculosis and is mostly spread through person to person contact. It causes multisystem infection and eventually might lead to death of the infected person. Two types of
To Be Published : Dec 2019
Anti-body coupled T receptor (ACTR) therapy is kind of immunotherapy used to treat cancer in which body’s own immune response is utilized to act on cancerous cell. Anti-body coupled T receptor therapy utilizes T cells from body, engineered it to express specific
To Be Published : Dec 2019
Human papillomavirus infection is most common sexually transmitted infection caused by HPV-related cancers such as cervical and genital cancer. Human papillomavirus infection vaccines are used to prevent genital wart, anal cancer, cervical cancer, and vaginal cancer.
To Be Published : Dec 2019
Hepatitis is an infectious disease caused due to hepatitis virus type A, B, and C, which leads to liver associated disease such as Hepatitis A, hepatitis B, hepatitis C, liver cirrhosis, hepatocellular carcinoma, and liver failure. It may lead to death of infect
To Be Published : Dec 2019
Gene synthesis is chemically in vitro synthesis of double-stranded DNA molecules. It is a technology used in biotechnology and plays an important role in the field of synthetic biology. The technology has become a significant tool in various fields of recombinant DNA
To Be Published : Dec 2019
Immune inhibitors are associated with haemophilia and inhibitors are antibodies developed in haemophilia patients. Haemophilia is a hereditary bleeding disorder, which occurs due to deficiency or absence of clotting factor VIII (haemophilia A) or clotting factor IX (h
To Be Published : Dec 2019
Diabetes is one of most prevalent chronic diseases worldwide. According to WHO (World Health Organization), diabetes was one of top three leading causes of mortality in 2012. The diabetes vaccine currently under development has significant potential in younger age gro
To Be Published : Dec 2019
Ebola virus disease (EVD) causes viral hemorrhagic fever. It is a life threatening disease, which is spread to humans from animals. Direct contact with body fluids of infected person is one of largest causes of spread of this infection. Symptoms of Ebola disease inclu
To Be Published : Dec 2019
Orthobiologics are substances used to heal injuries such as fractures and injured muscles, ligaments, and tendons within a short period of time. Orthobiologics are made from substances that naturally occur in the body. Some examples of orthobiologics are bone grafts,
To Be Published : Dec 2019
Biosimilar is a biological product that resembles a reference product and is not difference from the already approved reference product. These are relatively cheaper than branded or approved products. Several biologics for oncology have already lost their patents, and
To Be Published : Dec 2019
Cell banking is a process of replicating and storing cells for the purpose of future use. Storage of these cell samples can be utilized for research purposes and for surgical reconstruction of damaged body structures. Cells are frozen in cryovials at -196 degrees Cels
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