The biotech industry includes bio-pharma, bio-services, bio-agri, bio-industrials and bioinformatics. Biopharma is a rapidly growing segment that accounts for a dominant share in this sector. Advancements in biotechnology have enabled researchers to evaluate and identify target biomarkers/cell receptors to develop targeted and personalized therapies. Scientific research and technological advancements have resulted in the emergence of various personalized medicines that are undergoing research. According to research conducted by the Personalized Medicine Coalition, 42% of all compounds and 73% of oncology compounds in the pipeline possess the potential to be personalized medicine. Moreover, according to this study, it is expected that companies will increase their investment in R&D of personalized medicines by 1/3rd over the following five years. The study found that over 20% of drugs approved in 2014 were personalized medicines.

The biotechnology sector has witnessed some disruptive innovations such as gene and cell therapies, immunotherapy, and antibody drug conjugates. Advancement in stem cell therapy is resulting in effective treatment therapies for chronic conditions, organ growth and repair and disease prevention.

Key Challenges

Biotech products have extensive application in oncology and autoimmune disease treatment. However, the cost of these drugs is high owing to extensive research and trials that need to be carried out for the same. Therefore, there is constant pressure to reduce price and increase accessibility, especially in emerging economies. In the U.S., companies are facing reimbursement issues with respect to biopharmaceutical products. Besides, there are regulatory and scientific challenges faced by the sector. Scientific research for new molecules and targeted therapies is capital intensive and challenging owing to growing concern for safety of the drug.

Also, there is lack of awareness about personalized medicine among most healthcare providers, which may hamper its adoption. Clinical adoption of biotechnology products is essential for its success. However, it significant scientific evidence and backing is required to ensure its safety.

“Translating genomic discoveries into personalized medicines entails overcoming substantial scientific, regulatory, and economic challenges, including identifying validated biomarkers, as well as developing personalized therapeutics and clinically relevant diagnostic tests.”

  • Tufts Center for the Study of Drug Development


The biopharmaceutical sector offers vast lucrative growth opportunities. High efficacy and safety of biopharmaceutical products has led to a growth in their demand, Furthermore, consumers are willing to pay high prices for biopharmaceutical products compared to other conventional products. Biopharmaceutical brands have set new standards for blockbuster drugs by recording an annual average sale of over US$ 2bn. Drugs such as Humira have generated sales revenue of over US$ 10bn.

Governments in emerging economies are endorsing biosimilars as cost-effective alternatives to biotech products, which is expected to create significant growth opportunities for manufacturers of generic drugs. Therefore, cost-effectiveness and high quality are prime parameters that need to be considered while developing biosimilars. Recent and upcoming biologic patent expirations include the following:

  • Erbitux (cetuximab) - February 2016
  • Rituxan (rituximab) - September 2016
  • Herceptin (trastuzumab) - June 2019
  • Avastin (bevacizumab) - July 2019
  • Aranesp (darbepoetin alfa) - May 2024
  • Enbrel (etanercept) - November 2028

Companies such as Teva Pharmaceuticals, Hospira, Sandoz, and Amgen are focusing on development of biosimilars and vaccines as preventive measures in addition to treatment. For instance, in 2015, Zarxio TM became the first biosimilar to be approved in the U.S. market. The EMA approved Mosquirix, a malaria vaccine, in the same year. Extensive research is currently underway to develop a dengue vaccine, which could be another breakthrough pharmaceutical product in the near future.


The increasing research in the biotechnology sector is expected to result in higher number of biopharmaceutical products seeking FDA approvals. Biopharmaceuticals are positioned to be promising treatment solutions that would improve patient outcomes and help with reduction of the cost of drug development.

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Biotechnology Published Insights

Coherent Market Insights Single Use Bioreactor Market

Published Date : Nov 2022

Single-use bioreactors (SUBs) are emerging as a major technology in the field of pharmaceuticals. SUBs have become an established addition to today’s biotechnology manufacturing facilities, as they are widely being used in both the pharmaceutical and biopharmace... View more

Coherent Market Insights Pegylated Proteins Market

Published Date : Nov 2022

PEGylation is a process of addition of active polyethylene glycol (PEG) to different forms of therapeutic proteins for chemical modification. These chemically modified therapeutic proteins are called PEGylated protein therapeutics. PEGylated protein therapeutics are u... View more

Coherent Market Insights Us Influenza Vaccines Market

Published Date : Nov 2022

Influenza is commonly referred as flu, a contagious respiratory illness which is caused by influenza virus. The virus can cause mild to severe illness, resulting in serious outcomes such as hospitalization or death. Geriatric population, pregnant women, and people wit... View more

Coherent Market Insights Newborn Calf Serum Market

Published Date : Nov 2022

Newborn calf serum is the liquid portion of clotted blood taken from healthy, slaughtered bovine calves younger than 20 days that have been confirmed to be suitable for human consumption. It is widely used in industrial and academic research. It is one of the suppleme... View more

Coherent Market Insights Pulmonary Surfactant Market

Published Date : Nov 2022

Pulmonary surfactant is a complex and highly surface active material composed of lipids and proteins which is found in the fluid lining the alveolar surface of the lungs. Surfactant plays a vital role in pulmonary physiology. It’s major biophysical functions is ... View more

Coherent Market Insights Immuno Oncology Assays Market

Published Date : Nov 2022

Immuno-oncology is emerging as a novel approach to cancer treatment through the stimulation of the body's own immune system. It is a formidable weapon against cancer as it has the ability to harness the body's natural defenses against infection. It is method that tap ... View more

Coherent Market Insights Clostridium Difficile Diagnostics Market

Published Date : Nov 2022

Clostridium difficile infection (CDI) is diagnosed with the help of conventional laboratory testing methods, however, rapid point-of-care diagnostic tests are also available, which can save time and costs significantly. Clostridium difficile is a disease caused by bac... View more

Coherent Market Insights Aptamers Market

Published Date : Oct 2022

Aptamers are short single-stranded DNA or RNA (ssDNA or ssRNA) molecules that bind to a specific target protein, lipid, or nucleic acid molecules with high specificity. Aptamers can also be conjugated to drugs, and work as drug-delivery systems. For example, aptamers ... View more

Coherent Market Insights Patient Temperature Monitoring Market

Published Date : Oct 2022

A temperature monitoring system regulates and controls the temperature of a particular environment. A patient temperature monitoring helps in measurement of the body temperature which helps in detection of the patient illness. The patient temperature monitoring is use... View more

Coherent Market Insights Human Embryonic Stem Cells Market

Published Date : Oct 2022

Stem cells are biological cells that can differentiate into other types of cells, and are used for therapeutic purposes. Recent developments or advancements have paved the way for a plethora of potential therapies, due to which, therapies involving human embryonic ste... View more

Coherent Market Insights Protein Engineering Market

Published Date : Oct 2022

Protein engineering is the process of developing useful and/or valuable proteins (protein drugs). Protein therapeutics are a rapidly expanding segment of FDA approved drugs that will improve clinical outcomes over the long run. The technology can be used to develop pr... View more

Coherent Market Insights Glycobiology Market

Published Date : Oct 2022

Glycobiology is the branch of science which deals with the study of Glycan and glycan-modified biomolecules such as glycolipids, glycoproteins and glycosylated small molecules collectively referred to as sugar molecules. Glycan are universal in all aspects of life. Th... View more

Coherent Market Insights Cell Culture Market

Published Date : Sep 2022

The technique of growing cells outside the human body itself is a significant advancement in scientific research. Cell culture technique is adopted since mid-20th century and the field is continuously expanding into various areas of pharmaceutical research and develop... View more

Coherent Market Insights Research Antibodies Market

Published Date : Sep 2022

The small proteins known as antibodies, which are an essential component of immune system's reaction to diseases, are helpful in biomedical research. For decades, researchers have been developing antibodies to fight and understand viruses like Covid-19 and many common... View more

Coherent Market Insights Dna Extraction Kits Market

Published Date : Sep 2022

The DNA testing process is comprised of four main steps, including extraction, quantitation, amplification, and capillary electrophoresis. DNA extraction is a method used to purify DNA by using physical/chemical methods from a sample separating DNA from cell membranes... View more

Coherent Market Insights Cell Expansion Market

Published Date : Sep 2022

Cell expansion is the production of daughter cells from a single cell. Cell expansion requires the creation of new cell wall material and organized releasing of the wall to allow it to stretch and increase in area. Cell-wall-associated proteins are key components in c... View more

Coherent Market Insights Biophotonics Market

Published Date : Sep 2022

Biophotonics refers to the combination of field of photonics and biology. It is a light-based technology used in medicine and life-science for generation, detection of photons, manipulation, and quantum units of lights. This technology is also used in the study of the... View more

Coherent Market Insights Stem Cell Therapy Market

Published Date : Sep 2022

Stem cell therapy is a form of regenerative medicine designed to repair damaged cells within the body by reducing inflammation and modulating the immune system. This phenomenon makes stem cell therapy a viable treatment option for a variety of medical conditions. ... View more

Coherent Market Insights Cell Free Protein Expression Market

Published Date : Sep 2022

Cell-free protein expression, also known as in vitro translation, in vitro protein expression, cell-free translation, or cell-free protein synthesis, is the production of recombinant proteins in cell lysates rather than within cultured cells. Cell-free protein express... View more

Coherent Market Insights Conjugate Vaccine Market

Published Date : Sep 2022

Conjugate vaccine is a combination of a weak antigen with a strong antigen so as to provide active immunization against immune system having a stronger response to the weak antigen. In a conjugate vaccine, the weak antigen is covalently attached to a strong antigen an... View more

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