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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Clustered regularly interspaced short palindromic repeats (CRISPR) technology is a simple yet powerful nucleic acid-targeting editing tool for genome. It allows researchers to easily alter DNA sequences and modify gene function. It has potential applications, which include correcting genetic defects, treating, and preventing the spread of diseases. The technology is faster, cheaper, and more accurate than previous techniques of editing DNA such as ZFNs (Zinc Finger Nucleases) and TALENs (Transcription Activator-Like Effector Nucleases). Researchers are focusing on its use in animal models or isolated human cells, with the aim to eventually use the technology for routinely treating diseases in humans.

Global CRISPR and CAS Gene Market - Impact of the Coronavirus (COVID-19) Pandemic

The COVID-19 pandemic is expected to drive the growth of the global CRISPR and CAS gene market over the forecast period. As the number of COVID-19 cases have increased, the demand for efficient diagnostic tools have also increased and this encouraged the players operating in CRISPR and CAS gene market to develop diagnostic technologies for COVID-19 detection. Moreover, the regulatory authorities granted emergency use authorizations to the products developed by market players in order to combat the COVID-19 pandemic. The increased product approvals helped market players in expanding their product offerings as a result of which the market players could strengthen their presence in the CRISPR and CAS gene market. For instance, in September 2020, the Drug Controller General of India (DCGI) granted approval for the commercial launch of FELUDA, a COVID-19 detection test developed by the TATA Group by using CRISPR technology.

Furthermore, market players started focusing on growth strategies such as collaborations and agreements in order to ramp up the production of diagnostic tools and meet the demand for COVID-19 diagnostics in the market. For instance, in May 2020, Mammoth Biosciences collaborated with GlaxoSmithKline Plc to develop an easy-to-use, accurate, rapid, and fully disposable test for COVID-19 detection by using Mammoth Biosciences CRISPR-based DETECTR platform. Also, in October 2020, Mammoth Biosciences signed agreements with MilliporeSigma (a Merck company) and Hamilton Company for the commercialization of CRISPR-based SARS CoV-2 test.

 The global CRISPR and CAS gene market is estimated to be valued at US$ 830.7 Mn in 2020 and is expected to exhibit a CAGR of 22.8% over the forecast period (2020-2027).

Figure 1: Global CRISPR and CAS Gene Market Share (%) Analysis, By Product Type, 2020

CRISPR and CAS Gene  | Coherent Market Insights

Increasing number of clinical trials associated with CRISPR technology are being initiated by market players and research institutes to develop the treatment for diseases such as β-thalassemia, sickle cell disease, myeloma, solid tumors and hematologic malignancies, diabetes, and others, which is expected to drive the market growth over the forecast period

Increasing research & development activities for CRISPR gene editing is expected to drive the growth of the market over the forecast period. For instance, in 2018, CRISPR Therapeutics and Vertex launched the first in-human clinical trial of CRISPR genome editing technology. The trial was conducted to test an experimental therapy for the blood disorder, β-thalassemia, in Regensburg, Germany. Moreover, according to the Congressional Research Service, a public policy research institute of the U.S. Congress, the number of CRISPR-related scientific publications increased from 87 in 2011 to 3,917 in 2018.

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CRISPR and CAS Gene Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2020: US$ 830.7 Mn
Historical Data for: 2017 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 22.8% 2027 Value Projection: US$ 3,494.4 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Product Type: Vector-based Cas, DNA-free Cas, Others
  • By Application: Genome Engineering, Disease Models, Functional Genomics, Knockdown/Activation, Others
  • By End User: Biotechnology and Pharmaceutical Companies, Academic & Government Research Institutes, Contract Research Organizations
Companies covered:

Thermo Fisher Scientific Inc., Merck KGaA (Sigma-Aldrich), OriGene Technologies, Inc., New England Biolabs, Cellecta, Inc., Agilent Technologies, Inc., Applied StemCell, Inc., Synthego, Genscript, Mirus Bio LLC, Integrated DNA Technologies, Inc., and Mammoth Biosciences, Inc.

Growth Drivers:
  • Increasing number of clinical trials associated with CRISPR technology
  • Increasing investments and funding for gene editing technologies
  • Increasing strategic collaborations among the market players
  • Increasing development of novel technologies
Restraints & Challenges:
  • Increasing ethical and safety issues
  • Availability of alternatives 

Market players and government authorities are engaged in increasing investments and funding for gene editing technologies, which is expected to drive the growth of the market over the forecast period

Increasing investments and funding for gene editing technologies is expected to drive the growth of the market over the forecast period. For instance, the table below provides the details of funds raised by the companies, which are developing edited genes using the CRISPR technology:

Company Name Fund Raised (US$) Year Details
Editas Medicine 48.5 million  January 2018  The company received this fund after completing at-the-market offerings.
57.2 million  December 2017  The funds were raised in follow-on offerings.

CRISPR Therapeutics AG

 
122.6 million  January 2018 The funds were raised in subsequent follow-on offerings
 187.6 million  September 2018

Global CRISPR and CAS Gene Market – Restraints

Global CRISPR and CAS gene market growth is expected to be hampered in the near future, owing to the increasing ethical and safety issues about CRISPR and CAS gene therapy for gene editing and creating genetically modified (GM) food or organism. The major ethical concern associated with CRISPR technology is modification of the human germline. The CRISPR technology is designed to alter the defected human gene in order to treat certain disorders. Many ethicists have raised the concern that using CRISPR technology will modify the natural DNA of humans, which is unethical. Moreover, in April 2015, the US National Institutes of Health issued a statement indicating that it will not fund any research that uses genome editing tools such as CRISPR in human embryos due to ethical issues.

Moreover. availability of alternatives is also expected to restrain the growth of the market over the forecast period. Market players are developing various alternate methods for CRISPR/Cas9 in order to achieve high specificity. For example, Cas-CLOVER is an alternative to CRISPR/Cas9 developed by Hera BioLabs, an innovative pre-clinical contract services, products & licensing company. Cas-CLOVER is a fusion protein that comprises a nuclease-inactivated Cas9 protein fused to the Clo51 endonuclease and requires both paired L and R gRNAs for on-site targeting. The requirement of two guide RNAs with activity dependent upon relatively strict spacer lengths results in a highly specific genome editing tool as compared to CRISPR.

Global CRISPR and CAS Gene Market – Regional Analysis

On the basis of region, the global CRISPR and CAS gene market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold a dominant position in the global CRISPR and CAS gene market, owing to the increasing strategic collaborations in the region. For instance, in February 2018, Kite Pharma, Inc.—a Gilead Sciences, Inc. company— collaborated with Sangamo Therapeutics Inc. for developing engineered cell therapies to treat cancer. As per the agreement, Kite Pharma, Inc. will use Sangamo Therapeutics zinc finger nuclease (ZFN) gene-editing technology for developing next-generation ex vivo cell therapies for treatment of cancer.

Furthermore, Europe is also estimated to witness significant growth in the CRISPR and CAS gene market, owing to the increasing development of novel technologies in the region. For instance, in 2017, Merck KGaA— Germany-based company—developed a new genome editing tool dubbed proxy-CRISPR which provides access to previously inaccessible microenvironments of the genome modification using chromatin modifications.

Figure 2: Global CRISPR and CAS Gene Market Value (US$ Mn), by Region, 2020

CRISPR and CAS Gene  | Coherent Market Insights

Global CRISPR and CAS Gene Market – Competitive Landscape

Major players operating in the global CRISPR and CAS gene market include Thermo Fisher Scientific Inc., Merck KGaA (Sigma-Aldrich), OriGene Technologies, Inc., New England Biolabs, Cellecta, Inc., Agilent Technologies, Inc., Applied StemCell, Inc., Synthego, Genscript, Mirus Bio LLC, Integrated DNA Technologies, Inc., and Mammoth Biosciences, Inc.

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 is a unique technology that enables the geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the deoxyribonucleic acids (DNA) sequence. The CRISPR-Cas9 system consists of two key molecules that introduce a mutation into the DNA. The first component is an enzyme, which is called as Cas9. This acts as a pair of ‘molecular scissors’ that can cut the two strands of DNA at a specific location in the genome so that bits of DNA can then be added or removed. The second component is called guide RNA (gRNA). This consists of a small piece of pre-designed RNA sequence (about 20 bases long) located within a longer RNA scaffold. The scaffold part binds to DNA and the pre-designed sequence ‘guides’ Cas9 to the right part of the genome. This makes sure that the Cas9 enzyme cuts at the right point in the genome.

Market Dynamics

Key players are developing various treatment options, such as CRISPR and CAS genes, for genetic diseases. For instance, in 2016, the U.S.-based company, Addgene, developed the KamiCas9, a version of CRISPR-Cas9 that includes a 'self-inactivating' KamiCas9 system for the editing of central nervous system (CNS) disease genes for the treatment of Huntington’s disease.

CRISPR technology is widely used to develop therapeutics for diseases such as diabetes, cancer, etc. Hence, the increasing prevalence of such diseases is expected to drive the market growth over the forecast period. According to The International Diabetes Federation, in 2019, approximately 463 million adults (20-79 years of age) were living with diabetes; by 2045, this will increase to 700 million worldwide. Moreover, one in five of the people who are above 65 years old have diabetes.

Furthermore, according to data findings by the World Health Organization (WHO), in February 2018, cancer was the second-leading cause of death globally, and around 18.1 million new cases and 9.6 million deaths were registered due to cancer. According to the same source, around 70% of deaths from cancer occurred in low and middle income countries, and around one in six deaths across the globe were caused by cancer.

 Key features of the study:

  • This report provides an in-depth analysis of global CRISPR and CAS gene market, provides market size (US$ Million), and compound annual growth rate (CAGR %) for the forecast period (2020-2027), considering 2019 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategies adopted by the leading players
  • It profiles leading players in the global CRISPR and CAS gene market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments and strategies, and future plans
  • Key companies covered as a part of this study include Thermo Fisher Scientific Inc., Merck KGaA (Sigma-Aldrich), OriGene Technologies, Inc., New England Biolabs, Cellecta, Inc., Agilent Technologies, Inc., Applied StemCell, Inc., Synthego, Genscript, Mirus Bio LLC, Integrated DNA Technologies, Inc., and Mammoth Biosciences, Inc.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global CRISPR and CAS gene market report caters to various stakeholders in this industry including investors, suppliers, manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision making through various strategy matrices used in analyzing the CRISPR and CAS gene market

Detailed Segmentation:

  • Global CRISPR and CAS Gene Market, By Product Type:
    • Vector-based CAS
    • DNA-free CAS
    • Others
  • Global CRISPR and CAS Gene Market, By Application:
    • Genome Engineering
    • Disease Models
    • Functional Genomics
    • Knockdown/Activation
    • Others
  • Global CRISPR and CAS Gene Market, By End User:
    • Biotechnology and Pharmaceutical Companies
    • Academic & Government Research Institutes
    • Contract Research Organizations
  • Global CRISPR and CAS Gene Market, By Region:
    • North America
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
    • Middle East
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Product Type:
        • Vector-based CAS
        • DNA-free CAS
        • Others
      • By Application:
        • Genome Engineering
        • Disease Models
        • Functional Genomics
        • Knockdown/Activation
        • Others
      • By End User:
        • Biotechnology and Pharmaceutical Companies
        • Academic & Government Research Institutes
        • Contract Research Organizations
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Thermo Fisher Scientific Inc. *
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Strategies
    • Merck KGaA (Sigma-Aldrich)
    • OriGene Technologies, Inc.
    • New England Biolabs
    • Cellecta, Inc.
    • Agilent Technologies, Inc.
    • Applied StemCell, Inc.
    • Synthego
    • Genscript
    • Mirus Bio LLC
    • Integrated DNA Technologies, Inc.
    • Mammoth Biosciences, Inc.

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Overview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Product Type
      • Market Snippet, By Application
      • Market Snippet, By End User
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Market Trends
    • Impact Analysis
    • Technology Overview
    • Product/ Brand Analysis
    • Pipeline Analysis
    • Regulatory Scenario
    • Collaborations & Agreements
    • PEST Analysis
  4.  Global CRISPR and CAS Gene Market - Impact of Coronavirus (Covid-19) Pandemic
    • COVID-19 Epidemiology
    • COVID-19 Diagnosis through CRISPR Technology
    • Combating COVID-19 through CRISPR Technology
    • Impact on Market Players
  5. Global CRISPR and CAS Gene Market, By Product Type, 2016-2027 (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 - 2027
      • Segment Trends
    • Vector-based Cas
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • DNA-free Cas
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
  6. Global CRISPR and CAS Gene Market, By Application, 2016 - 2027 (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 - 2027
      • Segment Trends
    • Genome Engineering
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Disease Models
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Functional Genomics
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Knockdown/Activation
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
  7. Global CRISPR and CAS Gene Market, By End User, 2016 - 2027 (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 - 2027
      • Segment Trends
    • Biotechnology and Pharmaceutical Companies
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Academic & Government Research Institutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
    • Contract Research Organizations
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 - 2027, (US$ Million)
  8. Global CRISPR and CAS Gene Market, By Region, 2016 - 2027 (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, For Regions, 2017 - 2027
      • Regional Trends
    • North America
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016 - 2027 (US$ Mn)
        • U.S.
        • Canada
    • Latin America
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016 - 2027 (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016 - 2027 (US$ Mn)
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016 - 2027 (US$ Mn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016 - 2027 (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Product Type, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Application, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By End User, 2016 - 2027 (US$ Mn)
      • Market Size and Forecast, By Country/Region, 2016 - 2027 (US$ Mn)
        • South Africa
        • Central Africa
        • North Africa
  9. Competitive Landscape
    • Company Profiles
      • Thermo Fisher Scientific Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Merck KGaA (Sigma-Aldrich)
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • OriGene Technologies, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • New England Biolabs
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Cellecta, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Agilent Technologies, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Applied StemCell, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Synthego
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Genscript
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Mirus Bio LLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Integrated DNA Technologies, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
      • Mammoth Biosciences, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Developments/Updates
        • Strategies
    • Analyst Views
  10. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 31 market data tables and 23 figures on "CRISPR and CAS Gene Market” - Global Forecast to 2027.

FAQgrowicon

Frequently Asked Questions

The global CRISPR and CAS gene market is expected to exhibit a CAGR of 22.8% during the forecast period (2020-2027).
The market is estimated to be valued at US$ 830.7 Mn in 2020.
Thermo Fisher Scientific Inc., Merck KGaA (Sigma-Aldrich), OriGene Technologies, Inc., New England Biolabs, Cellecta, Inc., Agilent Technologies, Inc., Applied StemCell, Inc., Synthego, Genscript, Mirus Bio LLC, Integrated DNA Technologies, Inc., and Mammoth Biosciences, Inc. are some of the prominent players operating in the market over the forecast period.
The market is expected to be valued at US$ 3,494.4 Mn in 2027.
Vector-based CAS are the mostly used products in the market.
North America is the prominent region in the market.
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