Tooth regeneration is a stem cell-based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by growing them from autologous stem cells. Enamel faces the challenge of maintaining its integrity in a constant demineralization and remineralization within the oral environment and it is vulnerable to wear, damage, and decay. It cannot regenerate itself, because it is formed by a layer of cells that are lost after the tooth eruption.
The global tooth regeneration market is estimated to be valued at US$ 4530.6 million in 2022 and is expected to exhibit a CAGR of 5.8% during the forecast period (2022-2030).
Figure 1. Global Tooth Regeneration Market Share (%), by Population Demographics, 2022
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Various regulatory issues coupled with increasing spending on dental healthcare is expected to further support growth of tooth regeneration market growth.
Tooth regeneration market revenue is expected to be further driven by various macroeconomic factors. Various regulatory issues coupled with increasing spending on dental healthcare is expected to further support growth of tooth regeneration market growth. Favorable demographic trends along with expansion of commercial insurance and Medicaid insurance represents favorable market environment for growth of dental products, including those undergoing research. For instance, in March 2017, according to the data published by the Dental, Oral, and Craniofacial Tissue Regeneration Consortium (DOCTRC) DOCTRC program is supported in part by the National Institute of Dental & Craniofacial Research of the National Institutes of Health under Award Numbers U24DE026914, U24DE026915, U24DE029462, and U24DE029463. C-DOCTOR represents a partnership among faculty at several California institutions, including USC, UC San Francisco/âBerkeley/âDavis, UCLA, and Stanford. The DOCTRC initiative was designed to shepherd new therapies through pre-clinical studies and into human clinical trials, commercialization, and broad clinical adoption. The Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center (MPWRM RC) was established as an interdisciplinary partnership amongst the University of Michigan, the University of Pittsburgh, and the Wyss Institute, along with technology, clinical, regulatory, marketing, and commercial translation experts from private practice and industry. Through this collaborative effort, the resource center aims to accelerate clinical adoption of promising technologies by providing the interdisciplinary expertise and resources to guide technologies toward US Food and Drug administration submissions.
Tooth Regeneration Market Report Coverage
Report Coverage | Details | ||
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Base Year: | 2021 | Market Size in 2022: | US$ 4530.6 Mn |
Historical Data for: | 2017 to 2020 | Forecast Period: | 2022 to 2030 |
Forecast Period 2022 to 2030 CAGR: | 5.8% | 2030 Value Projection: | US$ 7110.5 Mn |
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Companies covered: |
Institute Straumann AG, DENTSPLY Sirona, Datum Dental, Camlog Biotechnologies AG, BioHorizons, Unilever, 3M, Zimmer Biomet, Ocata Therapeutics, Integra LifeSciences, CryoLife, BioMimetic Therapeutic, Cook Medical, Stem Cells Inc. |
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Restraints & Challenges: |
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Figure 2. Global Tooth Regeneration Market Share (%), by Region, 2022
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Increasing dental issues and the subsequent rise in the incidence of tooth loss is expected to drive the global tooth regeneration market.
Increasing dental issues like dental caries, arrested root formation, coronal discolorations, cavities (tooth decay) within geriatric population is expected to drive the global tooth regeneration market. For instance, in March 2022, according to the data published by the World Health Organization, globally, it is estimated that 2 billion people suffer from caries of permanent teeth and 520 million children suffer from caries of primary teeth. Moreover, according to the article published in The Journal of the American Dental Association, more than 1 in 5 the U.S. adults have untreated caries. The Journal of the American Dental Association study found the prevalence of untreated caries to be 21.3%, based on a weighted sample representative of 193.5 million U.S. adults. The Journal of the American Dental Association prevalence of coronal and root caries was 17.9% and 10.1%, respectively in the US.
Global Tooth Regeneration Market– Impact of Coronavirus (COVID-19) Pandemic :
Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization had declared it a public health emergency on January 30, 2020.
COVID-19 can affect the economy in three main ways: by directly affecting production and demand of drugs, medical devise, surgical procedure equipment’s etc., by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries, such as China, India, Saudi Arabia, U.A.E., Egypt, and others, are facing problems with regards to the transportation of drugs from one place to another.
However, the COVID-19 pandemic had a negative impact on the global tooth regeneration market, owing to decrease in surgical activities during the COVID-19 pandemic. For instance, the COVID-19 pandemic has significantly altered existing health care operations, including dentistry. The fear of SARS-CoV-2 infection and the need for increased protection measures have led to a reduction in the number of appointments and the range of performed procedures. The number of dental services was standardized against the sum of all procedures in a given month. During the COVID-19 pandemic, the number of conservative procedures such as commercial restorations or filled canals has significantly decreased. During the pandemic outbreak of coronavirus disease-2019 (COVID-19), dental services have highly contributed to the national efforts to reduce the spread of COVID-19 and its impact on the population. More specifically, the COVID-19 has reshaped the working environment for health practitioners, especially dentists. Routine treatments have been suspended during the pandemic period and dentists had to reorganize urgent care and implement appropriate measures to avoid cross-infections. COVID-19 has led to closure and reduced hours of dental practices except for emergency and urgent services, limiting routine care and prevention. Dental care includes aerosol-generating procedures that can increase viral transmission.
Global Tooth Regeneration Market: Key Developments
In May 2022, VideaHealth, an organization which has developed software for dental visualization, has got the approval by the US Food and Drug Administration for artificial intelligence algorithm that can help dentists identify cavities in patient X-rays. The FDA bestowed a 510(k) clearance upon an artificial intelligence algorithm from VideaHealth that can help dentists identify cavities in patient X-rays. The AI was built and trained using VideaHealth’s extensive database of dental X-rays, the Videa Factory, which the company says comprises the dental industry’s most diverse data set. It spans more than 100 million data points collected from dental service organizations, insurance companies, clearinghouses and universities. According to clinical trial results that were submitted to the FDA got approved, the AI helped reduce the number of caries lesions dentists missed by 43%. It also cut back on their incorrect diagnoses by about 15%.
In June 2022, VideaHealth, the leading dental artificial intelligence (AI) solution provider, announced it received a Medical Device Establishment License (MDEL) from Health Canada for Videa Caries Assist, an AI-powered dental caries (cavity) detection algorithm. VideaHealth's AI and software solutions help dentists better analyze patient X-rays and capture faster reimbursements and provide greater transparency and accuracy for treatment recommendations. Achieving MDEL in Canada follows VideaHealth’s recent FDA 501(k) clearance of Videa Carries Assist and its trial that demonstrated how the company’s cavity detection AI algorithm significantly improved dentists’ diagnostic accuracy without introducing new workflow steps.
Global Tooth Regeneration Market: Restraint
The major factors that hinder growth of the global tooth regeneration market include lack of skilled professionals and high cost of tooth regeneration process.
Key Players
Major players operating in the global tooth regeneration market include Institute Straumann AG, DENTSPLY Sirona, Datum Dental, Camlog Biotechnologies AG, BioHorizons, Unilever, 3M, Zimmer Biomet, Ocata Therapeutics, Integra LifeSciences, CryoLife, BioMimetic Therapeutic, Cook Medical, Stem Cells Inc.
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