Anti Cathepsin B Market
Cathepsin B is a cysteine protease found mainly in the lysosomes of normal cells but is secreted or associated with the plasma membrane of many transformed cells. It is found in all animals and other organisms and plays a key role in cellular protein metabolism. The cathepsin family includes serine proteases, aspartic proteases, and cysteine proteases. The aspartyl protease class consists of cathepsins D and E. The cysteine protease class consists of cathepsins B, L, H, K, S, and O. Currently, there are no approved cathepsin inhibitors on the market, but research is ongoing to develop new cathepsin inhibitors for the treatment of various diseases such as cancer, traumatic brain injury, Ebola infection, and others. Anti-Cathespin B antibodies are majorly used for the treatment of disease conditions such as cancer, traumatic brain injury, Ebola infection, and fertility problems, and are currently under research for the treatment of SARS-CoV-2. Cathepsin B is a protease that contributes to the remodeling of the extracellular matrix and thereby promotes keratinocyte migration during wound healing.
Market Dynamics
Increasing practices of treatments, mergers, and acquisitions by key market players are expected to drive the global anti-cathepsin B market growth. For instance, on March 31, 2020, National Center for Biotechnology Information published an article explaining Cathepsin B (CTSB) is an abundant cysteine protease that functions in both endolysosomal compartments and extracellular regions. Many preclinical and clinical studies indicate that CTSB is involved in many human diseases. CTSB expression levels and activity are significantly correlated with disease progression and severity. Current CTSB inhibitors lack sufficient specificity and pharmacological activity. Using structure-based rational design, researchers developed and produced a humanized antibody inhibitor targeting human CTSB.
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