ENZYME ENGINEERING MARKET SIZE AND SHARE ANALYSIS - GROWTH TRENDS AND FORECASTS (2025 - 2032)

Enzyme Engineering Market, By Product Type (Industrial enzymes, Specialty/medical enzymes, and Custom/contract-engineered enzymes), By Engineering Approach (Rational Design, Directed Evolution, Semi-Rational Design, and De Novo Enzyme Design), By Source (Microbial Enzymes, Plant-Derived Enzymes, Animal-Derived Enzymes, and Synthetic/Artificial Enzymes), By Modification Type (Amino Acid Substitution, Enzyme Fusion/Chimeric Enzymes, Immobilized Enzymes, Glycoengineering, and Stability and Thermotolerance Enhancement), By End User (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes, Industrial Manufacturers, and Diagnostic Laboratories and Centers), By Geography (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa)

Published In: 17 Dec, 2025
Code: CMI9091
Pages: 168
Formats: Excel and PDF
Industry: Biotechnology
- Historical Range: 2020 - 2024
- Forecast Period: 2025 - 2032

The Global Enzyme Engineering Market is estimated to be valued at USD 8.63 Bn in 2025 and is expected to reach USD 16.29 Bn by 2032, reflecting a compound annual growth rate (CAGR) of 9.5% from 2025 to 2032. Enzyme engineering represents a transformative biotechnological approach that involves the deliberate modification of enzymes to enhance their catalytic properties, stability, and specificity for industrial applications.

This rapidly evolving field combines principles of molecular biology, protein chemistry, and computational design to create optimized biocatalysts that address specific industrial challenges across pharmaceutical, food and beverage, textile, and chemical manufacturing sectors. The global enzyme engineering market has emerged as a critical component of the broader biotechnology landscape, driven by increasing demand for sustainable manufacturing processes, cost-effective production methods, and environmentally friendly alternatives to traditional chemical catalysts.

Advanced techniques such as directed evolution, rational design, and semi-rational approaches have revolutionized enzyme development, enabling researchers to create highly efficient biocatalysts with tailored properties. The market encompasses various enzyme classes including hydrolases, oxidoreductases, transferases, and ligases, each serving distinct industrial purposes from pharmaceutical synthesis to biofuel production.

As industries increasingly prioritize green chemistry initiatives and sustainable production methodologies, enzyme engineering has positioned itself as an indispensable technology for achieving improved process efficiency, reduced environmental impact, and enhanced product quality across diverse manufacturing applications.

Market Dynamics

The global enzyme engineering market is propelled by several key drivers that collectively fuel its robust growth trajectory, with the primary catalyst being the escalating demand for sustainable and eco-friendly manufacturing processes across industries as companies seek to reduce their carbon footprint and comply with stringent environmental regulations.

The pharmaceutical sector's increasing reliance on biocatalysis for drug synthesis, coupled with the growing adoption of personalized medicine requiring specialized enzymatic processes, significantly contributes to market expansion.

Additionally, the rising popularity of industrial biotechnology applications, including biofuel production, textile processing, and food manufacturing, creates substantial opportunities for engineered enzymes that offer superior performance characteristics compared to their natural counterparts. However, the market faces notable restraints including high research and development costs associated with enzyme engineering projects, lengthy development timelines that can span several years, and complex regulatory approval processes that vary across different regions and applications.

Technical challenges related to enzyme stability under industrial conditions, scalability issues in transitioning from laboratory to commercial production, and limited awareness about enzyme engineering benefits among small and medium enterprises also pose significant barriers to market growth.

Nevertheless, emerging opportunities abound through advancing computational tools and artificial intelligence integration in enzyme design, expanding applications in emerging markets such as bioplastics and renewable chemicals, and increasing government support for biotechnology research through funding initiatives and favorable policies that encourage innovation in sustainable manufacturing technologies.

Key Features of the Study

This report provides in-depth analysis of the global enzyme engineering market, and provides market size (USD Billion) and compound annual growth rate (CAGR%) for the forecast period (2025–2032), considering 2024 as the base year
It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
This study also provides key insights about market drivers, restraints, opportunities, new product launches or approvals, market trends, regional outlook, and competitive strategies adopted by key players
It profiles key players in the global enzyme engineering market based on the following parameters – company highlights, products portfolio, key highlights, financial performance, and strategies
Key companies covered as a part of this study include Novozymes A/S, DuPont de Nemours Inc (IFF), DSM‑Firmenich, Codexis Inc, AB Enzymes GmbH, Amano Enzyme Inc, BASF SE, Thermo Fisher Scientific Inc, Chr. Hansen Holding A/S, Dyadic International Inc, Biocatalysts Ltd, Sanofi, Creative Enzymes, Advanced Enzyme Technologies Ltd, and Brain Biotech AG
Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
The global enzyme engineering market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global enzyme engineering market

Market Segmentation

Product Type Insights (Revenue, USD Bn, 2020 - 2032)
- Industrial enzymes (process-focused: carbohydrases, proteases, lipases, polymerases, nucleases, oxidoreductases, phytases, cellulases, amylases)
- Specialty/medical enzymes (therapeutic enzymes, diagnostic enzymes, restriction enzymes, ligases, reporter enzymes)
- Custom/contract-engineered enzymes (tailor-made biocatalysts, library-based variants, OEM enzyme kits for third parties)
Engineering Approach Insights (Revenue, USD Bn, 2020 - 2032)
- Rational Design
- Directed Evolution
- Semi-Rational Design
- De Novo Enzyme Design
Source Insights (Revenue, USD Bn, 2020 - 2032)
- Microbial Enzymes
- Plant-Derived Enzymes
- Animal-Derived Enzymes
- Synthetic/Artificial Enzymes
Modification Type Insights (Revenue, USD Bn, 2020 - 2032)
- Amino Acid Substitution
- Enzyme Fusion/Chimeric Enzymes
- Immobilized Enzymes
- Glycoengineering
- Stability and Thermotolerance Enhancement
End User Insights (Revenue, USD Bn, 2020 - 2032)
- Pharmaceutical and Biotechnology Companies
- Academic and Research Institutes
- Industrial Manufacturers
- Diagnostic Laboratories and Centers
Regional Insights (Revenue, USD Bn, 2020 - 2032)
- North America
  - U.S.
  - Canada
- Latin America
  - Brazil
  - Argentina
  - Mexico
  - Rest of Latin America
- Europe
  - Germany
  - U.K.
  - Spain
  - France
  - Italy
  - Russia
  - Rest of Europe
- Asia Pacific
  - China
  - India
  - Japan
  - Australia
  - South Korea
  - ASEAN
  - Rest of Asia Pacific
- Middle East
  - GCC Countries
  - Israel
  - Rest of Middle East
- Africa
  - South Africa
  - North Africa
  - Central Africa
Key Players Insights
- Novozymes A/S
- DuPont de Nemours Inc (IFF)
- DSM‑Firmenich
- Codexis Inc
- AB Enzymes GmbH
- Amano Enzyme Inc
- BASF SE
- Thermo Fisher Scientific Inc
- Hansen Holding A/S
- Dyadic International Inc
- Biocatalysts Ltd
- Sanofi
- Creative Enzymes
- Advanced Enzyme Technologies Ltd
- Brain Biotech AG

Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
Market Purview
- Report Description
  - Market Definition and Scope
- Executive Summary
  - Global Enzyme Engineering Market, By Product Type
  - Global Enzyme Engineering Market, By Engineering Approach
  - Global Enzyme Engineering Market, By Source
  - Global Enzyme Engineering Market, By Modification Type
  - Global Enzyme Engineering Market, By End User
  - Global Enzyme Engineering Market, By Region
Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Driver
- Restraint
- Opportunity
- Impact Analysis
- Key Developments
- Regulatory Scenario
- Product Launches/Approvals
- PEST Analysis
- PORTER’s Analysis
- Merger and Acquisition Scenario
- Industry Trends
Global Enzyme Engineering Market, By Product Type, 2020-2032, (USD Bn)
- Introduction
  - Market Share Analysis, 2025 and 2032 (%)
  - Y-o-Y Growth Analysis, 2021 - 2032
  - Segment Trends
- Industrial enzymes (process-focused: carbohydrases, proteases, lipases, polymerases, nucleases, oxidoreductases, phytases, cellulases, amylases)
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Specialty/medical enzymes (therapeutic enzymes, diagnostic enzymes, restriction enzymes, ligases, reporter enzymes)
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Custom/contract-engineered enzymes (tailor-made biocatalysts, library-based variants, OEM enzyme kits for third parties)
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
Global Enzyme Engineering Market, By Engineering Approach, 2020-2032, (USD Bn)
- Introduction
  - Market Share Analysis, 2025 and 2032 (%)
  - Y-o-Y Growth Analysis, 2021 - 2032
  - Segment Trends
- Rational Design
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Directed Evolution
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Semi-Rational Design
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- De Novo Enzyme Design
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
Global Enzyme Engineering Market, By Source, 2020-2032, (USD Bn)
- Introduction
  - Market Share Analysis, 2025 and 2032 (%)
  - Y-o-Y Growth Analysis, 2021 - 2032
  - Segment Trends
- Microbial Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Plant-Derived Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Animal-Derived Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Synthetic/Artificial Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
Global Enzyme Engineering Market, By Modification Type, 2020-2032, (USD Bn)
- Introduction
  - Market Share Analysis, 2025 and 2032 (%)
  - Y-o-Y Growth Analysis, 2021 - 2032
  - Segment Trends
- Amino Acid Substitution
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Enzyme Fusion/Chimeric Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Immobilized Enzymes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Glycoengineering
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Stability and Thermotolerance Enhancement
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
Global Enzyme Engineering Market, By End User, 2020-2032, (USD Bn)
- Introduction
  - Market Share Analysis, 2025 and 2032 (%)
  - Y-o-Y Growth Analysis, 2021 - 2032
  - Segment Trends
- Pharmaceutical and Biotechnology Companies
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Academic and Research Institutes
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Industrial Manufacturers
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
- Diagnostic Laboratories and Centers
  - Introduction
  - Market Size and Forecast, and Y-o-Y Growth, 2020-2032, (USD Bn)
Global Enzyme Engineering Market, By Region, 2020 - 2032, Value (USD Bn)
- Introduction
  - Market Share (%) Analysis, 2025, 2028 & 2032, Value (USD Bn)
  - Market Y-o-Y Growth Analysis (%), 2021 - 2032, Value (USD Bn)
  - Regional Trends
- North America
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country, 2020 - 2032, Value (USD Bn)
    - U.S.
    - Canada
- Latin America
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country, 2020 - 2032, Value (USD Bn)
    - Brazil
    - Argentina
    - Mexico
    - Rest of Latin America
- Europe
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country, 2020 - 2032, Value (USD Bn)
    - Germany
    - U.K.
    - Spain
    - France
    - Italy
    - Russia
    - Rest of Europe
- Asia Pacific
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country, 2020 - 2032, Value (USD Bn)
    - China
    - India
    - Japan
    - Australia
    - South Korea
    - ASEAN
    - Rest of Asia Pacific
- Middle East
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country, 2020 - 2032, Value (USD Bn)
    - GCC Countries
    - Israel
    - Rest of Middle East
- Africa
  - Introduction
  - Market Size and Forecast, By Product Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Engineering Approach, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Source, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Modification Type, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By End User, 2020 - 2032, Value (USD Bn)
  - Market Size and Forecast, By Country/Region, 2020 - 2032, Value (USD Bn)
    - South Africa
    - North Africa
    - Central Africa
Competitive Landscape
- Novozymes A/S
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- DuPont de Nemours Inc (IFF)
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- DSM‑Firmenich
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Codexis Inc
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- AB Enzymes GmbH
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Amano Enzyme Inc
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- BASF SE
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Thermo Fisher Scientific Inc
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Hansen Holding A/S
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Dyadic International Inc
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Biocatalysts Ltd
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Sanofi
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Creative Enzymes
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Advanced Enzyme Technologies Ltd
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
- Brain Biotech AG
  - Company Highlights
  - Product Portfolio
  - Key Developments
  - Financial Performance
  - Strategies
Analyst Recommendations
- Wheel of Fortune
- Analyst View
- Coherent Opportunity Map
References and Research Methodology
- References
- Research Methodology
- About us

*Browse 32 market data tables and 28 figures on ‘Enzyme Engineering Market' - Global forecast to 2032

Limited Time Offer - Buy Now

Need a Custom Report?

We can customize every report - free of charge - including purchasing stand-alone sections or country-level reports
Customize Now