DNA AND RNA SAMPLE PREPARATION MARKET ANALYSIS

The global DNA and RNA sample preparation market is estimated to be valued at US$ 2,021.2 million in 2023 and is expected to exhibit a CAGR of 5.8 % during the forecast period (2023-2030).

Analysts’ Views on Global DNA and RNA Sample Preparation Market:

Increasing prevalence of infective disorders, launches of new products by key market players as well as strategies such as mergers and acquisition, partnerships are expected to drive the global DNA and RNA sample preparation market over the forecast period. Infectious diseases such as Acquired Immune Deficiency Syndrome (AIDS), pneumonia, hepatitis require the diagnosis via preparation of DNA & RNA. For instance, according to data shared by National Center for Health Statistics from National Ambulatory Medical Care Survey in 2020, nearly 765,000 emergency department visits were taken place resulting in hospital admission due to diagnosis of infectious and parasitic diseases. There are globally 300–500 million cases of malaria, 333 million cases of sexually transmitted diseases, 33 million cases of Human immunodeficiency virus infection (HIV), 14 million people infected with tuberculosis, and 3–5 million cases of cholera.

Figure 1. Global DNA and RNA Sample Preparation Market Share (%), by Product Type, 2023

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Global DNA and RNA Sample Preparation Market – Driver

Prevalence of infectious diseases across the world

The cases of infectious diseases are constantly rising worldwide. Due to this global burden of infectious diseases, the need for accurate, reliable and newer detection technologies are required. Hence, this factor can drive growth of global DNA and RNA sample preparation market. For instance, according to data reported by the World Health Organization, on April 21, 2023, a total of 1.6 million people died from Tuberculosis (TB) in 2021. Worldwide, TB is the 13th leading cause of death and the second leading infectious killer after COVID-19. In 2021, an estimated 10.6 million people fell ill with tuberculosis (TB) worldwide. Only about 1 in 3 people with drug resistant TB received treatment in 2021.

Increasing launches of new products

Rapid diagnosis and treatment of infectious disease is necessary due to increased burden of infectious diseases. Hence, key market players are focused on receiving approvals of newer diagnostic kits. For instance, on November 30, 2022, Mylab discovery solutions, India based biotechnology company received Central Drugs Standard Control Organization (CDSCO) and Indian Council of Medical Research (ICMR) approval for its product PathoDetect. It is a Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) based kit that allows automated testing of multiple samples within 2 hours. It is a TB detection kit, which can simultaneously detect multiple drug resistance to rifampicin and isoniazid in single test.

Figure 2. Global DNA and RNA Sample Preparation Market Value (US$ Million), by Region, 2023

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Global DNA and RNA Sample Preparation Market - Regional Analysis

Among regions, North America is estimated to hold a dominant position in the global DNA and RNA sample preparation market over the forecast period. This is attributed to product launches by key market players. For instance, on June 6, 2022 PerkinElmer Inc., U.S.-based diagnostic services company, launched BioQule system for next generation sequencing library preparation of up to eight samples. It incorporates automated thermocycling, optical quantification and liquid handling technology into a single device. It produces high quality next generation sequencing (NGS) libraries that can give reliable, reproducible results in genomic analysis.

Global DNA and RNA Sample Preparation Market – Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease spread to over 100 countries across the globe, and the World Health Organization declared it a public health emergency on January 30, 2020.

COVID-19 affected the economy in three main ways: by directly affecting the production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries such as China, India, Saudi Arabia, the U.A.E., Egypt, and others are facing problems with the transportation of drugs from one place to another.

However, the COVID-19 pandemic had a positive impact on the global DNA and RNA sample preparation market. This is because, DNA and RNA sample preparation is required in the diagnosis of COVID-19. For instance, on March 27, 2020, Abbott Laboratories, U.S.-based healthcare company, announced that it got U.S. Food and Drug Administration approval for emergency use authorization to its new COVID-19 detection kit, ID NOW. It is isothermal nucleic acid amplification technology that can provide molecular results in few minutes.  

Global DNA and RNA Sample Preparation Market Segmentation:

The global DNA and RNA sample preparation market report is segmented into by product type, by application, by end user, by region.

Based on Product type, the global DNA and RNA sample preparation market is segmented into workstations, kits and reagents & consumables. Out of which, the kits are expected to dominate the global DNA and RNA sample preparation market during the forecast period and this is due to the increased research and development activities in area of kits.

Based on Application, the global DNA and RNA sample preparation market is segmented into clinical testing, diagnostic testing, and research applications. The diagnostic testing segment is expected to dominate the market over the forecast period and this is attributed to the increasing number of patients that require such diagnostic testing.

Based on End user, the global DNA and RNA sample preparation market is segmented into hospitals, diagnostic centers, academic research institutes, forensic science laboratories and contract research organizations. The diagnostic centers are expected to dominate the market over the forecast period and this is due to the increasing patient visits to diagnostic centers.

Among all the segmentations, the product type segment has the highest potential due to developments of newer detection methods in kit technologies over the forecast period. For instance, on April 1, 2021, Altona Diagnostics, a Germany-based medical equipment company, announced launch of AltoStar HIV RT-PCR kit. It can diagnose and give reliable viral load monitoring of viruses such as HIV (Human immunodeficiency viruses), Hepatitis B and Hepatitis C. This kit is designed for both DNA and RNA extraction and validated for use with several sample types.

Global DNA and RNA Sample Preparation Market Cross Sectional Analysis:

Increasing launches of newer kit technologies by key market players are driving growth of product type segment in North America region. For instance, on March 7, 2023, PerkinElmer Inc., U.S. based testing laboratories company launched new NEXTFLEX Rapid XP V2 DNA-Sequencing kit. It is low cost instrument that delivers libraries ready to load into sequencer.  It shortens the time needed for quantification and pooling preparation for sequencing in a high throughput lab by up to 3 hours per 96 samples.

Global DNA and RNA Sample Preparation Market: Key Developments

On March 2, 2021, Agilent Inc., a U.S.-based biotechnology company, acquired Resolution Bioscience, U.S.-based cancer diagnostic company to strengthen its position in oncology diagnostic solutions. This combination brings together Resolution Bioscience’s noninvasive liquid biopsy platform that improves cancer diagnostics with Agilent’s tissue-based companion diagnostics on commercial and regulatory scale. This will also accelerate precision oncology testing for patients worldwide through distributed NGS-based diagnostic kits.

On April 9, 2020, Bio-Rad Laboratories Inc., a U.S.-based life science research and clinical diagnostic company, acquired Celsee Inc, another U.S-based biotechnological company that offers instruments and consumables for isolation, detection and analysis of single cells. The Celsee's Genesis System can scale from hundreds of thousands to millions of cells for genomic and proteomic applications and can enrich or monitor circulating tumor cells to determine disease progression and therapeutic response. The terms of acquisition were not disclosed.

In August 22, 2022, Qiagen, a Germany-based molecular diagnostic company, launched new solutions, QIAseq targeted DNA pro panels and QIAseq UPXome RNA Library Kit, which can be used in preparing samples for determining their nucleic acid sequencing.  This can significantly accelerate DNA variant detection and RNA sequencing of low-input samples. They provides ease of use, efficiency and expanded, ultra-sensitive variant analysis using integrated unique molecular indices (UMIs). The panels are powerful tools for detecting genetic variations such as somatic mutations, single nucleotide polymorphisms, and copy number variations.

On March 2, 2022, Beckman Coulter Life Sciences, a U.S.-based diagnostic company, launched CellMek SPS, a fully automated sample preparation system for clinical flow cytometer. In this system, the sample can be washed, stained, lysed without need of manual intervention. This system offers on-demand processing for a multitude of sample types to help laboratories to expand capabilities.

Global DNA and RNA Sample Preparation Market: Key Trends

Initiatives by key market players for launch of new products

On October 18, 2022, Twist Bioscience, a U.S.-based biotechnology company, launched Human sample ID kit to track whole blood samples throughout period of lab testing workflow. The twist human sample ID kit can be easily integrated into twist new generation sequencing workflows and enables tracking from whole blood or purified genomic DNA to ensure sample identification throughout the lab workflow.

Global DNA and RNA Sample Preparation Market: Restraint

High cost of DNA & RNA sample preparation methods

DNA & RNA sample preparation is the first and essential step of any biological procedure. However, the materials and the labor work required in preparation of sample is very costly. Hence, it results into increasing overall cost of process. Also, available kits have limited throughput so scaling it to higher sample requires automation. The reagents used are also very costly. For instance, according to article published by BMC Genomics on August 24, 2022, about 80% of the total costs of genomic sequencing occur prior to sequencing during DNA & RNA extraction.

To counter balance the restrain, government funding should be given to promote research and development activities in biotechnological fields.

Problems with RNA sample handling

RNA preparation and handling is the challenge faced by diagnostic laboratories. According to an article published by International Journal of Molecular Sciences, on January 20, 2023, obtaining a full length and high quality RNA can be challenging. This is because, while working in the environment it should be free from RNase. Sample should be frozen immediately after collection. Logistics problems can also cause a delay in sampling hence compromising quick tissue processing for RNA isolation. RNA may get degraded if not handled and stored properly. 

To counter balance this problem, proper precautions should be taken care and material should be handled and stored carefully.

Global DNA and RNA Sample Preparation Market - Key Players

Major players operating in the global DNA and RNA sample preparation market include Agilent Technologies, Inc., Becton, Dickinson and Company, Bio-Rad Laboratories Inc., DiaSorin S.p.A, F. Hoffmann-La Roche, Miroculus, Inc., Illumina, Inc., PerkinElmer, Inc., QIAGEN, Sigma Aldrich Corp., Tecan Group AG, and Thermo Fisher Scientific, Inc.