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Ankylosing spondylitis (AS) is a rare type of inflammation that mainly affects spine and can damage large joints of body. It causes inflammation in the spinal joints (vertebrae), thereby causing severe pain and discomfort. Over time, ankylosing spondylitis can cause some bones in the spine to fuse together, as a result of which the spine becomes less flexible. Symptoms of ankylosing spondylitis include pain and stiffness in the hips and lower back.
The global ankylosing spondylitis market is estimated to be valued at US$ 4,864.3 million in 2021 and is expected to exhibit a CAGR of 8.2% during the forecast period (2021-2028).
Figure 1.Global Ankylosing Spondylitis Market Share (%) in Terms of Value, by Drug Type, 2021
Increasing prevalence of ankylosing spondylitis is expected to drive the market growth during the forecast period.
The increasing prevalence of ankylosing spondylitis is expected to drive the global ankylosis spondylitis market growth during the forecast period. For instance, according to an article published by ‘Frontiers in Medicine’ journal in March 2021, the epidemiological data in Taiwan stated that the prevalence of ankylosing spondylitis is 96.9 per 100,000 people.
| Report Coverage | Details | ||
|---|---|---|---|
| Base Year: | 2020 | Market Size in 2021: | US$ 4,864.3 Mn |
| Historical Data for: | 2017 to 2020 | Forecast Period: | 2021 to 2028 |
| Forecast Period 2021 to 2028 CAGR: | 8.2% | 2028 Value Projection: | US$ 8,460.7 Mn |
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| Companies covered: |
Amgen Inc., AbbVie Inc., Pfizer Inc., Novartis AG, Bristol-Myers Squibb Company, CELGENE CORPORATION, Eli Lilly and Company, Cipla Inc., Emcure Pharmaceuticals, Torrent Pharmaceuticals Ltd., UCB S.A., Suzhou Zelgen Biopharmaceuticals Co., Ltd., HENGRUI USA, and Johnson & Johnson Services, Inc. |
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| Restraints & Challenges: |
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Figure 2. Global Ankylosing Spondylitis Market Share (%), by Distribution Channel, 2021
Increasing strategic alliances between the companies to develop or to expand the availability of drugs is expected to drive the market growth during the forecast period.
Key players in the market are focusing on inorganic growth strategies, such as partnerships and collaborations which is expected to drive the market growth during the forecast period.
For instance, in August 2021, Inmagene Biopharmaceuticals, a leading biotech company focused on the development of therapeutics for immunology-related diseases, and Affibody AB, a company developing innovative bi- and multi-specific next-generation biopharmaceuticals, working in a partnership, announced the successful dosing of the first patient in the global ASPIRE phase 2 trial evaluating izokibep (IMG-020 or ABY-035) for treating ankylosing spondylitis (AS).
Global Ankylosing Spondylitis Market – Impact of Coronavirus (COVID-19) Pandemic
Accessing medical services can be challenging for people with ankylosing spondylitis during the COVID-19 pandemic. While some drugs for ankylosing spondylitis can be self-administered, some are given through an IV in hospitals. Similarly, physical therapy requires a visit to the physical therapist, which has been difficult due to the COVID-19 pandemic.
Biologics such as TNF (Tumor Necrosis factor) inhibitors, used in ankylosing spondylitis treatment, may increase the risk of infections and lower the body's ability to fight infections, including COVID-19, because these medications cause a suppressing effect on the immune system. Biologics including IL-17 and IL-12/23 inhibitors are used for treating ankylosing spondylitis, but have the same immunosuppressive effect that may increase the risk of infections. Thus, due to this, the growth of the global ankylosing spondylitis market is expected to be hampered.
Ankylosing spondylitis is an immune-mediated inflammatory disease (IMID). According to a study conducted in Ontario, Canada, in 2020, it was found that people with IMIDs were tested for COVID-19 at a 20% higher rate, as compared to the general population.
Global Ankylosing Spondylitis Market: Restraint
The major factors that are expected to hinder growth of the global ankylosing spondylitis market include high cost of treatment and lack of skilled surgeons and physiotherapists.
Key Players
Major players operating in the global ankylosing spondylitis market include Amgen Inc., AbbVie Inc., Pfizer Inc., Novartis AG, Bristol-Myers Squibb Company, CELGENE CORPORATION, Eli Lilly and Company, Cipla Inc., Emcure Pharmaceuticals, Torrent Pharmaceuticals Ltd., UCB S.A., Suzhou Zelgen Biopharmaceuticals Co., Ltd., HENGRUI USA, and Johnson & Johnson Services, Inc.
Ankylosing spondylitis is an inflammation (chronic inflammatory arthritis) that mostly affects the spine. It generally causes stiffness and pain in the back. Over time, movement of the back gradually becomes limited as the bones of the spine become fused. This fusion is called ankylosing. Ankylosing spondylitis can also involve other joints such as the hips, shoulders and sometimes knees. Over time, it can affect the joints between the ribs and spine, restricting the movement of the chest and causing a difficulty in breathing deeply. Symptoms of ankylosing spondylitis include frequent pain and stiffness in buttocks and the lower back, which comes on progressively after a few weeks or months. At first, discomfort may be felt only on one side, or alternate sides. The pain is usually diffuse and dull, rather than localized. Other symptoms in the early stages include loss of appetite, mild fever, and general discomfort. Currently, there is no cure for AS, but there are treatments and drugs available to manage pain and reduce symptoms.
Market Dynamics
The increasing launches of new drugs for ankylosing spondylitis are expected to drive the market growth during the forecast period. For instance, in November 2021, Pfizer’s XELJANZ (tofacitinib) received marketing authorization by the European Commission, in the European Union for the treatment of active ankylosing spondylitis. It received approval for the administration of 5 mg XELJANZ (tofacitinib) twice daily for the treatment of adults with active ankylosing spondylitis (AS) who have not responded adequately to conventional therapy. The approval of XELJANZ for ankylosing spondylitis was based on the data obtained from a Phase 3, multicenter, randomized, double-blind, placebo-controlled study that evaluated the safety and efficacy of XELJANZ (tofacitinib) 5 mg twice daily versus placebo in 269 adult patients with active ankylosing spondylitis.
Key features of the study:
Detailed Segmentation:
“*” marked represents similar segmentation in other categories in the respective section.
The global ankylosing spondylitis market size is estimated to be valued at US$ 4,864.3 million in 2021 and is expected to exhibit a CAGR of 8.2% between 2021 and 2028.
Factors such as rising prevalence of ankylosing spondylitis, increasing launch of biosimilars, and increasing research & development efforts being undertaken by key industry players to augment treatment options are expected to drive growth of the market during the forecast period.
Nonsteroidal anti-inflammatory drugs (NSAIDs) drug type segment is expected to hold a major market share during the forecast period.
The major factors hampering growth of the market include high cost of treatment and lack of skilled surgeons and physiotherapists.
Major players operating in the market include Amgen Inc., AbbVie Inc., Pfizer Inc., Novartis AG, Bristol-Myers Squibb Company, CELGENE CORPORATION, Eli Lilly and Company, Cipla Inc., Emcure Pharmaceuticals, Torrent Pharmaceuticals Ltd., UCB S.A., Suzhou Zelgen Biopharmaceuticals Co., Ltd., HENGRUI USA, and Johnson & Johnson Services, Inc.
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