Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial. It is an approved medical device used in bone defects, it has a long track record of clinical use in diverse forms. Demineralized bone matrices are prepared by acid extraction of allograft bone, resulting in loss of most of the mineralized component but retention of collagen and non-collagenous proteins including growth factors. Demineralized bone matrix is used to extend and bolster the bone graft. This is due to the ability of growth factors to control the differentiation of progenitor cells, which are responsible for bone and cartilage formation.
The Global Demineralized Bone Matrix Market is estimated to be valued at US$ 619.5 million in 2021 and is expected to exhibit a CAGR of 4.3 % during the forecast period (2021-2028).
Figure 1.Global Demineralized Bone Matrix Market Share (%) in Terms of Value, By Type, 2021
Rising incidence of orthopedic disorders is expected to drive the market growth during the forecast period.
Rising incidence of orthopedic disorders is expected to boost the global demineralized bone matrix market growth over the forecast period. For instance, according to the National Institute of Health and Family Welfare (NIHFW) (under the Ministry of Health and Family Welfare (MoHFW)), Government of India’s data, osteoarthritis is the second most common rheumatologic problem in India, and it is the most frequently diagnosed joint disease in India with a prevalence of 22% to 39% in 2018.
|Base Year:||2020||Market Size in 2021:||US$ 619.5 Mn|
|Historical Data for:||2017 to 2020||Forecast Period:||2021 to 2028|
|Forecast Period 2021 to 2028 CAGR:||4.3%||2028 Value Projection:||US$ 832.6 Mn|
Medtronic Plc, Johnson & Johnson (DePuy Synthes), Exactech, Inc., HansBioMed, Xtant Medical, Stryker, Arthrex GmbH, RTI Surgical, Zimmer Biomet., and Straumann
|Restraints & Challenges:||
Figure 2.Global Demineralized Bone Matrix Market Share (%), By Application, 2021
Increasing number of spinal fusion and dental surgeries are expected to drive the market growth during the forecast period.
Increasing number of spinal fusion and dental surgeries are expected to boost the market growth during the forecast period. For instance, according to National Spinal Cord Injury Statistical Center in 2018, the U.S. had around 17,700 new cases of spinal cord injury, and the number of people living with the spinal cord injury were found out to be around 288,000.
Global Demineralized Bone Matrix Market– Impact of Coronavirus (COVID-19) Pandemic
Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization has declared it a public health emergency. According to the World Health Organization’s report, the manifestation of coronavirus (COVID-19) has resulted in more than 191 million infected individuals worldwide as of July 21, 2021.
COVID-19 can affect the economy in three main ways; by directly affecting production and demand, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries such as China, India, Saudi Arabia, UAE, Egypt, and others are facing problems with regards to transportation of drugs from one place to another.
Furthermore, players operating in the global demineralized bone matrix market are facing major challenges on various fronts due to the COVID-19 pandemic. The major challenges include the supply of raw materials required for manufacturing drug formulations due to irregularities in transportation. Moreover, distributors are experiencing irregular demand of products from the retailers due to an increase in the number of patients suffering from COVID-19 and other life threatening disorders.
Global Demineralized Bone Matrix Market: Restraint
The major factors that hinder growth of the global demineralized bone matrix market include the high cost of demineralized bone matrix. For instance, the average cost of dental bone graft vary between US$ 400 and US$ 1,200 for end users in the U.S.
Major players operating in the global demineralized bone matrix market are Medtronic Plc, Johnson & Johnson (DePuy Synthes), Exactech, Inc., HansBioMed, Xtant Medical, Stryker, Arthrex GmbH, RTI Surgical, Zimmer Biomet, and Straumann
Demineralized bone matrix (DBM) is prepared from cortical bone that is derived from long bones. It is an allograft bone in which the inorganic mineral is removed and leaving behind the collagen matrix. The removal of the bone mineral exposes more biologically active bone morphogenetic proteins. Demineralized bone matrix is indicated to extend and strengthen the bone graft. This is due to the ability of growth factors to control the differentiation of progenitor cells, which are responsible for bone and cartilage formation. Demineralized bone matrix (DBM) is more biologically active as compared to mineralized bone grafts and aids in bone generation.
Key players operating in the global demineralized bone matrix market are focusing on adoption of growth strategies such as product launch and agreement, which is expected to boost the market growth during the forecast period. For instance, in July 2019, SeaSpine Holdings Corporation, a global medical technology company focused on surgical solutions for the treatment of spinal disorders, announced the product release of its OsteoStrand and OsteoStrand Plus demineralized bone fibers with its new integrated, hydration syringe system. Furthermore, in August 2018, BONESUPPORT, an emerging leader in orthobiologics for the management of bone voids, signed an agreement with MTF Biologics, the world’s largest tissue bank, to extend and strengthen its U.S. product offering. This agreement gave BONESUPPORT the U.S. rights to sell two forms of bone graft materials that are comprised of 100% demineralized bone matrix. BONESUPPORT launched the products supplied by MTF Biologics under BONESUPPORT brand name and distributed them through its own U.S. distribution network.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.