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Impact Analysis of Covid-19

The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.

Hypertriglyceridemia is a common disorder or condition in which the triglyceride levels in the blood are elevated. The increasing levels of triglyceride are mainly related to atherosclerosis and cardiovascular diseases (CVDs). This condition also causes pancreatitis, atherosclerosis, and other CVDs. New advancements in terms of diagnosis and treatment of hypertriglyceridemia for rapidly recovering the triglyceride levels in the human body are expected to boost the global hypertriglyceridemia therapeutics market growth.

The key players are investing in research & development and commercialization of novel drugs for the treatment of hypertriglyceridemia, which is expected to boost the market growth during the forecast period. Moreover, the growing prevalence of cardiovascular diseases and increasing sedentary habits are other factors propelling the market growth. For instance, according to the World Health Organization (WHO), around 17.9 million deaths reported in 2016 were due to cardiovascular diseases which are the leading cause of death across the globe.

Global Hypertriglyceridemia Therapeutics Market - Impact of Coronavirus (Covid-19) Pandemic

The hypertriglyceridemia therapeutics market growth has been impacted significantly due to the outbreak of COVID-19 across the world. As per the EMCrit Project, COVID-19 affected patients are more prone to developing hypertriglyceridemia, mainly due to systemic inflammation. Thus, ideally keeping the propofol dosages can help to maintain sedation and prevent conditions such as hypertriglyceridemia. It is becoming difficult for researchers and key industry players to perform clinical trials during this pandemic crisis. However, many market players such as Eli Lilly and Company, and Pfizer Inc. are investing in research and development of novel hypertriglyceridemia drugs.

The all-inclusive version of the report will include the impact of COVID-19 and the probable changes in the future outlook of the industry, by taking into account the technological, social, political, and economical parameters.

The hypertriglyceridemia therapeutics market is estimated to be valued at US$ 9,716.6 million in 2020 and is expected to register a CAGR of 4.09% during the forecast period (2020-2027).

Figure 1. Global Hypertriglyceridemia Therapeutics Market Share (%) Analysis, By Type, 2020

Hypertriglyceridemia Therapeutics  | Coherent Market Insights

The increasing research & development of drugs are expected to propel the global hypertriglyc eridemia therapeutics market growth during the forecast period

Key players are investing to in development of novel drugs and launching these products in the market which in turn, is estimated to significantly boost the market growth and create lucrative growth opportunities in the global hypertriglyceridemia therapeutics market during the forecast period.

For instance, in July 2019, Sun Pharma launched ‘Ezallor Sprinkle’ (Rosuvastatin) in the U.S. for the people having difficulty swallowing. Ezallor Sprinkle capsules are indicated as an adjunct to the diet for the hypertriglyceridemia adult patient’s treatment. It is also indicated as an adjunct to diet for the treatment of adult patients with type III hyperlipoproteinemi and to other lipid-lowering treatments.

Furthermore, the increasing number of drug approvals are expected to help companies strengthen their market position. For instance, in December 2019, Amarin received FDA approval for VASCEPA (icosapent ethyl) indicated for reducing cardiovascular risk. The novel indication for VASCEPA is that it is an adjunct to diet to reduce triglyceride levels in older patients with severe hypertriglyceridemia.

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Hypertriglyceridemia Therapeutics Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2019: US$ 9,716.6 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 4.09% 2027 Value Projection: US$ 12,863.1 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, Rest of Middle east
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Type: Primary, Secondary.
  • By Drug Class: Statins, Fibrates, Niacin, Omega-3 Fatty Acids, HMG-CoA Reductase inhibitors.
  • By Distribution Channel: Online Pharmacy, Retail Pharmacy, Hospital Pharmacy, Others.
Companies covered:

Sanofi, GlaxoSmithKline Plc, Biocon, Novo Nordisk A/S, Tonghua Dongbao Pharmaceutical Co., Ltd., Oramed Pharmaceuticals, Inc, Merck & Co., Inc., Julphar, Eli Lilly and Company, Bristol-Myers Squibb Company, Pfizer Inc., Adocia, Hikma Pharmaceutical PLC, Lupin Ltd., AbbVie Inc., Wockhardt, Zydus Pharmaceuticals Inc., Glenmark, Amneal pharmaceutical LLC, Aurobindo Pharma, and Accord Healthcare.

Growth Drivers:
  • Growing prevalence of cardiovascular diseases
  • Sedentary lifestyle
Restraints & Challenges:
  • High cost of the treatment
  • Lack of medical care

Hypertriglyceridemia Therapeutics Market – Regional Analysis

North America accounted for majority of the share in the global hypertriglyceridemia therapeutics market in 2019 and is expected to retain its dominance during the forecast period. This is majorly attributed to the growing healthcare expenditure, FDA approvals, and product launches in the hypertriglyceridemia therapeutics market. For instance, in July 2016, Mylan launched Rosuvastatin Calcium Tablets in the U.S., which are the generic version of Crestor (AstraZeneca’s tablet). The company received the U.S. Food and Drug Administration (FDA) approval for their ANDA (Abbreviated New Drug Application). Crestor tablets are used in combination with diet for treating hypertriglyceridemia in adults.

Moreover, the growing prevalence of obesity in the U.S. is projected to boost the growth of the regional market during the forecast period. For instance, according to the Centers for Disease Control and Prevention (CDC), the prevalence of obesity in the U.S. was 42.4% in 2017 and the rate is increasing at a rapid pace.

Furthermore, the market in Asia Pacific is expected to witness significant growth during the forecast period owing to drug approvals and surge in prevalence of cardiovascular diseases in the region. As per the Department of Nutrition and Health Sciences, cardiac problems account for seven out of every 10 deaths in Asian countries.

Figure 2. Global Hypertriglyceridemia Therapeutics Market Value (US$ Mn) & Y-o-Y Growth (%), 2017-2027

Hypertriglyceridemia Therapeutics  | Coherent Market Insights

Global Hypertriglyceridemia Therapeutics Market - Competitive Landscape

Key players operating in the global hypertriglyceridemia therapeutics market are Sanofi, GlaxoSmithKline Plc, Biocon, Novo Nordisk A/S, Tonghua Dongbao Pharmaceutical Co., Ltd., Oramed Pharmaceuticals, Inc, Merck & Co., Inc., Julphar, Eli Lilly and Company, Bristol-Myers Squibb Company, Pfizer Inc., Adocia, Hikma Pharmaceutical plc, Lupin Ltd., AbbVie Inc., Wockhardt Ltd., Zydus Pharmaceuticals, Glenmark Pharmaceuticals, Amneal pharmaceutical LLC, Aurobindo Pharma, and Accord Healthcare.

Hypertriglyceridemia is a condition and common disorder in which the triglyceride levels in the body increase. This rising levels of triglyceride are majorly associated with predisposing cardiovascular diseases and atherosclerosis, even in the absence of high cholesterol levels. Hypertriglyceridemia also causes pancreatitis, atherosclerosis, and other cardiovascular diseases. Currently, the advancements in treatment of hypertriglyceridemia are helping in recovering the triglyceride levels in the human body.

Market Dynamics

The ongoing research and development of developing novel drugs is expected to propel the global hypertriglyceridemia market growth during the forecast period. For instance, in March 2019, Arrowhead Pharmaceuticals initiated a phase I study of ‘ARO-APOC3’ for the treatment of hypertriglyceridemia. ARO-APOC3 is the company’s second cardio metabolic candidate entering clinical trials, following ARO-ANG3 for the treatment of metabolic diseases and dyslipidemias. Moreover, the growing prevalence of atherosclerosis and other cardiovascular diseases are fueling the market growth. For instance, according to the WHO, about 17.9 million deaths were reported in 2016 due to cardiovascular diseases.

Approvals of drugs and product launches are also expected to create growth opportunities for players operating in the global hypertriglyceridemia market. However, the high costs associated with the treatment and medical care in emerging economies is expected to hinder the market growth in the coming years.

Key features of the study:

  • This report provides in-depth analysis of the global hypertriglyceridemia market, market size (US$ Mn), and compound annual growth rate (CAGR (%)) for the forecast period: 2020-2027, considering 2019 as the base year
  • It elucidates potential revenue opportunity across different segments and explains an attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by leading players
  • It profiles key players in the global hypertriglyceridemia market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, key developments, and strategies
  • Key players covered as a part of this study are Biocon, Sanofi, Novo Nordisk A/S, GlaxoSmithKline Plc, Tonghua Dongbao Pharmaceutical Co., Ltd., Merck & Co., Inc., Oramed Pharmaceuticals, Inc, Wockhardt, Julphar, Pfizer, Inc., Eli Lilly and Company, Adocia, Bristol-Myers Squibb Company, Hikma Pharmaceutical PLC, AbbVie Inc., Lupin Ltd., Accord Healthcare, Zydus Pharmaceuticals Inc., Amneal pharmaceutical LLC, Glenmark, and Aurobindo Pharma.
  • Insights from this report would allow marketers and management authorities of companies to make informed decisions with respect to future product launches, governmental initiatives, technological up-gradation, market expansion, and marketing tactics
  • The global hypertriglyceridemia market report caters to various stakeholders in this industry, including investors, product manufacturers, distributors, and suppliers in the hypertriglyceridemia market, research and consulting firms, new entrants, and financial analysts.

Detailed Segmentation:

  • Global Hypertriglyceridemia Market, By Type:
    • Primary
    • Secondary
  • Global Hypertriglyceridemia Market, By Drug Class:
    • Statins
    • Fibrates
    • Niacin
    • Omega-3 Fatty Acids
    • HMG-CoA Reductase inhibitors
  • Global Hypertriglyceridemia Market, By Distribution Channel:
    • Online Pharmacy
    • Retail Pharmacy
    • Hospital Pharmacy
  • Global Hypertriglyceridemia Market, By Region:
    • North America
      • By Country:
        • U.S.
        • Canada
      • By Type:
        • Primary
        • Secondary
      • By Drug Class:
        • Statins
        • Fibrates
        • Niacin
        • Omega-3 Fatty Acids
        • HMG-CoA Reductase inhibitors
      • By Distribution Channel:
        • Online Pharmacy
        • Retail Pharmacy
        • Hospital Pharmacy
        • Others
    • Europe
      • By Country:
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
      • By Type:
        • Primary
        • Secondary
      • By Drug Class:
        • Statins
        • Fibrates
        • Niacin
        • Omega-3 Fatty Acids
        • HMG-CoA Reductase inhibitors
      • By Distribution Channel:
        • Online Pharmacy
        • Retail Pharmacy
        • Hospital Pharmacy
        • Others
    • Asia Pacific
      • By Country:
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
      • By Type:
        • Primary
        • Secondary
      • By Drug Class:
        • Statins
        • Fibrates
        • Niacin
        • Omega-3 Fatty Acids
        • HMG-CoA Reductase inhibitors
      • By Distribution Channel:
        • Online Pharmacy
        • Retail Pharmacy
        • Hospital Pharmacy
        • Others
    • Latin America
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
      • By Type:
        • Primary
        • Secondary
      • By Drug Class:
        • Statins
        • Fibrates
        • Niacin
        • Omega-3 Fatty Acids
        • HMG-CoA Reductase inhibitors
      • By Distribution Channel:
        • Online Pharmacy
        • Retail Pharmacy
        • Hospital Pharmacy
        • Others
    • Middle East
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
      • By Type:
        • Primary
        • Secondary
      • By Drug Class:
        • Statins
        • Fibrates
        • Niacin
        • Omega-3 Fatty Acids
        • HMG-CoA Reductase inhibitors
      • By Distribution Channel:
        • Online Pharmacy
        • Retail Pharmacy
        • Hospital Pharmacy
        • Others
  • Company Profiles
    • Biocon
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Strategies
    • Sanofi
    • Novo Nordisk A/S
    • GlaxoSmithKline Plc
    • Tonghua Dongbao Pharmaceutical Co., Ltd.
    • Merck & Co., Inc.
    • Oramed Pharmaceuticals, Inc
    • Wockhardt
    • Julphar
    • Pfizer, Inc.
    • Eli Lilly and Company
    • Adocia
    • Bristol-Myers Squibb Company
    • Hikma Pharmaceutical PLC
    • AbbVie Inc.
    • Lupin Ltd.
    • Accord Healthcare
    • Zydus Pharmaceuticals Inc.
    • Amneal pharmaceutical LLC
    • Glenmark
    • Aurobindo Pharma

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Overview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Type
      • Market Snippet, By Drug Class
      • Market Snippet, By Distribution Channel
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Technological Advancements in Hypertriglyceridemia
    • Key Developments
    • Acquisition, Collaborations & Partnerships
    • Pipeline Analysis
    • Patent Landscape
    • Pricing Analysis
    • Epidemiology
  4. Global Hypertriglyceridemia Therapeutics Market, Impact of Coronavirus (Covid-19) Pandemic
    • Pre-COVID situation
    • Post-COVID demand
    • Pipeline Analysis
    • Hypertriglyceridemia Epidemiology Study
    • Recommendations and Guidelines By Regulatory Bodies
  5. Global Hypertriglyceridemia Therapeutics Market, By Type, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Primary
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Secondary
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  6.  Global Hypertriglyceridemia Therapeutics Market, By Drug Class, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Statins
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Fibrates
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Omega-3 Fatty Acids
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • HMG-CoA Reductase inhibitors
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Niacin
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  7. Global Hypertriglyceridemia Therapeutics Market, By Distribution Channel, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017 – 2027
      • Segment Trends
    • Retail Pharmacy
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Hospitals Pharmacy
      • Introduction    
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Online Pharmacy
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
    • Others
      • Introduction    
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Million)
  8. Global Hypertriglyceridemia Therapeutics Market, By Region, 2016 – 2027, (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2020 and 2027(%)
      • Y-o-Y Growth Analysis, By Region, 2017 –2027
      • Regional Trends
    • North America
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.S.
        • Canada
    • Europe
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • China
        • Japan
        • India
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Africa
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country/Region, 2016 – 2027, (US$ Million)
        • North Africa
        • Central Africa
        • South Africa
    • Middle East
      • Market Size and Forecast, By Type, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Drug Class, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Distribution Channel, 2016 – 2027, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2027, (US$ Million)
        • GCC
        • Israel
        • Rest of Middle East
  9. Competitive Landscape
    • Company Profiles
      • Sanofi
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • GlaxoSmithKline Plc
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Biocon
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Novo Nordisk A/S
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Tonghua Dongbao Pharmaceutical Co., Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Oramed Pharmaceuticals, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Abbvie
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Merck & Co., Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Wockhardt
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Pfizer, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Julphar
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Eli Lilly and Company
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Bristol-Myers Squibb Company
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Pfizer Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Adocia
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Hikma Pharmaceutical PLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Lupin Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • AbbVie Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Wockhardt
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Zydus Pharmaceuticals Inc.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Glenmark
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Amneal pharmaceutical LLC
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Aurobindo Pharma
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
      • Accord Healthcare.
        • Company Overview
        • Product Portfolio
        • Financial Performance
        • Recent Highlights
        • Strategies
  10. Section
    • References
    • Research Methodology
    • About Us and Sales Contact

*Browse 26 market data tables and 28 figures on "Global Hypertriglyceridemia Therapeutics Market” - Forecast to 2027”

Frequently Asked Questions

The CAGR of the Hypertriglyceridemia market is expected to be 4.09% during the forecast period (2020-2027).
The value of the global Hypertriglyceridemia market was estimated to be valued at US$ 9,716.6 million in 2020.
The prominent players in hypertriglyceridemia therapeutics market across the globe are Sanofi, GlaxoSmithKline Plc, Biocon, Novo Nordisk A/S, Tonghua Dongbao Pharmaceutical Co., Ltd., Oramed Pharmaceuticals, Inc, Merck & Co., Inc., Julphar, Eli Lilly and Company, Bristol-Myers Squibb Company, Pfizer Inc., Adocia, Hikma Pharmaceutical PLC, Lupin Ltd., AbbVie Inc., Wockhardt, Zydus Pharmaceuticals Inc., Glenmark, Amneal pharmaceutical LLC, Aurobindo Pharma, and Accord Healthcare.
The global hypertriglyceridemia therapeutics market is expected to be valued at US$ 12,863.1 million in 2027.
The major region in the global hypertriglyceridemia therapeutics market is North America.
Sedentary lifestyle increasing the risk for high triglyceride levels and thus cardiovascular diseases
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