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Methadone hydrochloride is the hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Methadone hydrochloride is similar to morphine and other morphine-like agents, and exhibit therapeutics actions against  analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Methadone hydrochloride has prolonged half-life compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate withdrawal symptoms are less severe.

The global methadone hydrochloride market is estimated to be valued at US$ 105.3 million in 2020 and is expected to exhibit a CAGR of 4.0% during the forecast period (2020-2027).

Figure 1. Global Methadone Hydrochloride Market Value (US$ Mn), 2016-2027

Methadone Hydrochloride  | Coherent Market Insights

The global methadone hydrochloride market is primarily driven by increasing prevalence of pain associated with therapeutic and post-surgical treatment, which in turn increases demand for methadone hydrochloride. For instance, according to the report published by the U.S. Department of Health & Human Services in September 2018, in 2016, an estimated 20.4% of the U.S. adults had chronic pain and 8.0% of the U.S. adults had high-impact chronic pain. Both chronic pain and high impact chronic pain were more prevalent among adults living under poverty.

Furthermore, development and launches of novel methadone hydrochloride products by key companies is expected to drive the market growth over the forecast period. For instance, in November 2018, Elite Pharmaceuticals, Inc., a specialty pharmaceutical company developing abuse-deterrent opioids and niche generic products, announced the commercial launch of generic methadone hydrochloride 5 mg and 10 mg tablets by Glenmark Pharmaceuticals, Inc., U.S., (Glenmark), Elite’s marketing alliance partner. Through this alliance, Glenmark will sell and distribute certain generic products of Elite, including methadone, for which Elite will receive manufacturing and license fees.

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Methadone Hydrochloride Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2020: US$ 105.3 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 4.0% 2027 Value Projection: US$ 138.8 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of the Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Formulation: Tablet, Solution, Others.
  • By Application: Opiate Withdrawal, Chronic Pain, Others.
  • By Route of Administration: Oral, Intravenous.
  • By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies.
Companies covered:

Eli Lilly and Company, Sanofi S.A, Hikma Pharmaceuticals PLC, Mallinckrodt Pharmaceuticals, Siegfried Holding AG, Johnson Matthey, Tianjin Central Pharmaceutical Co., Ltd, Temad Co, Embio LTD, Harman Finochem Ltd, and Rusan Pharma Ltd

Growth Drivers:
  • Increasing prevalence of pain associated with therapeutic and post-surgical treatment
  • Increasing drug abuse globally
Restraints & Challenges:
  • Side effects such as constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, and stomach pain and also, patients might get addicted to methadone hydrochloride are associated with use of methadone hydrochloride

Global Methadone Hydrochloride Market – Impact of Coronavirus (COVID-19)

Following the outbreak of COVID-19 in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization declared it a public health emergency. According to the World Health Organization’s report, manifestation of coronavirus (COVID-19) has resulted in more than 69.9 million infected individuals worldwide as of December 11, 2020.

Moreover, COVID-19 has impacted each and every market around the world, and is expected to affect the global methadone hydrochloride market. Therefore, governments of various countries are taking various initiatives to combat COVID-19. For instance, in May 2020, the Centers for Disease Control and Prevention started working with government agencies and research institutes to increase testing capacity, improve case detection, and contact tracing across all states in the U.S. and re-open the country.

Furthermore, In response to a reduction in the accessibility of COVID-19 treatment service provision during the lockdown, some countries have increased low-threshold services and reduced barriers for obtaining opiate-substitution medication; for instance, allowing pharmacies to dispense methadone such as in the U.K.  In order to increase accessibility to opioid-substitution therapy, the U.K. is planning to dispense methadone without new prescriptions to those who already use it, although the measure has triggered concerns by the Advisory Council on the Misuse of Drugs that it may lead to an increase in drug misuse and diversion.

Figure 2. Global Methadone Hydrochloride Market Share (%), By Region, 2020

Methadone Hydrochloride  | Coherent Market Insights

North America is expected to hold dominant position in the global methadone hydrochloride market, owing to higher prevalence of chronic pain related to cancer and post-surgical pain. According to the report published by the Centers for Disease Control and Prevention (CDC) in 2018, over 1 in 5 adults in the U.S. experienced chronic pain in 2018

Key Players

Major players operating in the global methadone hydrochloride market include Eli Lilly and Company, Sanofi S.A, Hikma Pharmaceuticals PLC, Mallinckrodt Pharmaceuticals, Siegfried Holding AG, Johnson Matthey, Tianjin Central Pharmaceutical Co., Ltd, Temad Co, Embio LTD, Harman Finochem Ltd, and Rusan Pharma Ltd.

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Methadone, a synthetic narcotic analgesic is part of a category called opioids. This opioid has pharmacologic actions qualitatively similar to morphine. Methadone is generally used as a pain reliever and as a part of drug addiction detoxification and maintenance therapy. Pain can be of various types such as due to surgery, strain, and others. A person experiencing severe and chronic pain is given small doses of methadone, which encounters the pain by changing the way the brain and nervous system respond to pain. Opiate dependence is a major public health problem.

Market Dynamics

Key players are focusing on mergers and acquisitions to strengthen their position in the global methadone hydrochloride market. For instance, in May 2016, Hikma Pharmaceuticals PLC acquired Roxane Laboratories, Inc., a pharmaceutical company. Through this acquisition, the company expanded its product portfolio of opiate agonist by acquiring methadone hydrochloride from Roxane Laboratories, Inc

Key features of the study:

  • This report studies the current scenario as well as the future market potential of methadone hydrochloride across the globe. The market for methadone hydrochloride has been segmented on the basis of formulation, application, route of administration, distribution channel, and region.
  • This report provides in-depth analysis of the global methadone hydrochloride market, and provides market size (US$ Mn) and compound annual growth rate (CAGR) (%) for the forecast period (2020-2027)
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market. It provides valuable insights about market drivers, restraints, opportunities, regional outlook, and competitive strategies adopted by the leading players.
  • It profiles leading players in the global methadone hydrochloride market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, key developments, and future plans
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions with respect to their future market expansion and marketing tactics
  • Key companies covered as a part of this study are Eli Lilly and Company, Sanofi S.A, Hikma Pharmaceuticals PLC, Mallinckrodt Pharmaceuticals, Siegfried Holding AG, Johnson Matthey, Tianjin Central Pharmaceutical Co., Ltd, Temad Co, Embio LTD, Harman Finochem Ltd, and Rusan Pharma Ltd.
  • The global methadone hydrochloride market report caters to various stakeholders in this industry, including investors, product developers and manufacturers, distributors, healthcare organizations, research institutes, new entrants, and financial analysts
  • Stakeholders would greatly benefit in decision-making through various strategy matrices used in analyzing the global methadone hydrochloride market

Detailed Segmentation:

  • Global Methadone Hydrochloride Market, By Formulation :
    • Tablet
    • Solution
    • Others
  • Global Methadone Hydrochloride Market, By Application:
    • Opiate Withdrawal
    • Chronic Pain
    • Others
  • Global Methadone Hydrochloride Market, By Route of Administration :
    • Oral
    • Intravenous
  • Global Methadone Hydrochloride Market, By Distribution Channel :
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
  • Global Methadone Hydrochloride Market, By Region:
    • North America
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • U.S.
        • Canada
    • Latin America
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country:
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country/Region:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Formulation :
        • Tablet
        • Solution
        • Others
      • By Application:
        • Opiate Withdrawal
        • Chronic Pain
        • Others
      • By Route of Administration:
        • Oral
        • Intravenous
      • By Distribution Channel :
        • Hospital Pharmacies
        • Retail Pharmacies
        • Online Pharmacies
      • By Country/Region:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Eli Lilly and Company *
      • Company Overview
      • Material Portfolio
      • Financial Performance
      • Key Highlights
      • Market Strategies
    • Sanofi S.A
    • Hikma Pharmaceuticals PLC
    • Mallinckrodt Pharmaceuticals
    • Siegfried Holding AG
    • Johnson Matthey
    • Tianjin Central Pharmaceutical Co., Ltd
    • Temad Co
    •  Embio LTD
    • Harman Finochem Ltd
    • Rusan Pharma Ltd

“*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objectives and Assumptions
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snapshot, By Formulation
      • Market Snapshot, By Application 
      • Market Snapshot, By Route of Administration
      • Market Snapshot, By Distribution Channel
      • Market Snapshot, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Drivers and Restraints
    • Opportunities
    • Impact Analysis
    • Recent Product launches and Approvals
    • Pipeline Analysis
    • Brand Analysis
    • Regulatory Scenario
    • PEST Analysis
    • Epidemiology
    • Reimbursement Scenario
    • Acquisition
    • Market Trend
  4. Global Methadone Hydrochloride Market, Impact of COVID-19 Pandemic
    • Economic Impact
    • Research and Development
    • Government Analysis
  5. Global Methadone Hydrochloride Market, By Formulation, 2016-2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
        • Tablet
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Solution
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Others
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
  6. Global Methadone Hydrochloride Market, By Application, 2016–2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
        • Opiate Withdrawal
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Chronic Pain
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Others
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
  7. Global Methadone Hydrochloride Market, By Route of Administration, 2016–2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
        • Oral
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Intravenous
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
  8. Global Methadone Hydrochloride Market, By Distribution Channel, 2016–2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
        • Hospital Pharmacies
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Retail Pharmacies
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
        • Online Pharmacies
          • Introduction
          • Market Size and Forecast, and Y-o-Y Growth, 2016–2027, (US$ Mn)
  9. Global Methadone Hydrochloride Market, By Region, 2016–2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, By Country, 2020 and 2027 (%)
      • Y-o-Y Growth Analysis, For Countries, 2017–2027
    • North America
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016–2027 (US$ Mn)
        • U.S.
        • Canada
    • Latin America
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016–2027 (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016–2027 (US$ Mn)
        • Germany
        • U.K.
        • France       
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016–2027 (US$ Mn)
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country, 2016–2027 (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Introduction
      • Market Size and Forecast, By Formulation, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Application 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Route of Administration, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Distribution Channel, 2016–2027 (US$ Mn)
      • Market Size and Forecast, By Country/Region, 2016–2027 (US$ Mn)
        • South Africa
        • Central Africa
        • North Africa
  10. Competitive Landscape
    • Company Profiles
      • Eli Lilly and Company
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Sanofi S.A
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Hikma Pharmaceuticals PLC
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Mallinckrodt Pharmaceuticals
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Siegfried Holding AG
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Johnson Matthey
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Tianjin Central Pharmaceutical Co., Ltd
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Temad Co
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Embio LTD
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Harman Finochem Ltd
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Rusan Pharma Ltd
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies

*Browse 44 market data tables and 34 figures on " Methadone Hydrochloride Market – Global forecast to 2027”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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