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  • Published On : Jan 2023
  • Code : CMI5468
  • Industry : Pharmaceutical
  • Pages : 178
  • Formats :

The recent development in metaomics applications has extended the understanding of the human gut microbiota and its role in health and diseases. This increases the interest in using commensal bacteria as next-generation probiotic (NGP) for the prevention and treatment of disease as a novel health promoting approach. Next generation probiotics can develop either dietary supplement or novel drug that faces a new challenge in their efficacy, safety, technological robustness, and regulatory framework. Next generation probiotics to use as bio therapeutics must go through three rounds of clinical trials such as preclinical, toxicological studies and pharmacodynamics.

Global next generation probiotics market is estimated to be valued at US$ 168.1 million in 2022 and is expected to exhibit a CAGR of 11.2% during the forecast period (2022-2030).

Figure 1.Global Next Generation Probiotics Market Share (%), by Bacterial Candidate, 2022

Next Generation Probiotics  | Coherent Market Insights

Global Next Generation Probiotics Market- Drivers

Increasing product launches by key players in market are expected to drive market growth over the forecast period. For instance, in June 2021, FitBiomics, a sports biotechnology company, launched its first consumer product under Nella Brand, a next-generation probiotics supplement for gut health in active adults uniquely sourced from the microbiome of elite athletes.

Moreover, in September 2020, Lonza, a leading global provider of integrated healthcare solutions, announced the launch of its L. plantarum (TWK10) ingredient, which is originally isolated from fermented vegetables, specifically Taiwanese Kimchi. The unique patented TWK10 strain is the next generation of probiotics. It is also a novel probiotic designed to deliver sports nutrition benefits for both elite athletes and active consumers. The TWK10 brand is clinically shown to enhance endurance and improve body composition and energy levels.

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Next Generation Probiotics Market Report Coverage

Report Coverage Details
Base Year: 2021 Market Size in 2022: US$ 168.1 Mn
Historical Data for: 2017 to 2020 Forecast Period: 2022 to 2030
Forecast Period 2022 to 2030 CAGR: 11.2% 2030 Value Projection: US$ 393.9 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Bacterial Candidate: Akkermansia, Clostridium species, Bifidobacterium species, Lactobacillus species, Others  
  • By Application: Weight Management, Glucose Management, Inflammatory Bowel Diseases, Others
Companies covered:

Pendulum, Amsterdam Winclove Probiotics, Metabogen AB (Biogaia), Exeliom Biosciences, TargEDys, Chr. Hansen Holding A/S, YSOPIA Bioscience, A-Mansia Biotech, Next Gen Probiotics, Evolve Biosystems and DuPont de Nemours, Inc.

Growth Drivers:
  • Increasing product launches
  • Increasing research and development activities
Restraints & Challenges:
  • Difficulties associated with manufacturing of next generation probiotic products

Figure 2.Global Next Generation Probiotics Market Share (%), by Region, 2022

Next Generation Probiotics  | Coherent Market Insights

Global Next Generation Probiotics Market– Impact of Coronavirus (COVID-19) Pandemic

The supply of raw materials required for production of next generation probiotics has been severely disrupted due to the forced quarantine and lack of labor during the COVID-19 pandemic. As the link between regional warehouses is not smooth, transportation of raw materials between regions cannot be carried out successfully. This shortage of raw materials and components have negatively affected the supply chain of the next generation probiotics market. Thus, COVID-19 pandemic is expected to have negative impact on supply chain of next generation probiotics market.

According to an article published by the Exploratory Research in Clinical and Social Pharmacy Journal  is a peer reviewed, open access journal,  in June 2021, a study was carried out to evaluate the impact of COVID-19 on pharmaceutical systems and supply chain in  resource-limited countries in Sub-Saharan countries such as Namibia. This study revealed negative impact on availability and access of essential drugs, sanitation and hygiene products, and antimicrobials. Most pharmaceutical companies and pharmacies in Namibia experienced delayed manufacturing and distribution of drugs, which is attributed to reduced inter-country transportation of pharmaceutical goods and limited in-country capacity to manufacture drugs.

Moreover, according to data published by Multidisciplinary Digital Publishing Institute, a publisher of open access scientific journals, in April 2021, at this time of the COVID-19 pandemic, when no pharmacological strategies for prevention or treatment are available, attention to alternative therapies using probiotics must be considered. Emerging data suggest that changes in the immune homeostasis, induced by SARS CoV-2, might be mediated by gut microbiota. Elderly people have less diverse intestinal flora in which beneficial microorganisms deteriorate. This is in line with the observation that older individuals are more susceptible to SARS CoV-2 and more severe COVID-19. The administration of these NGPs, isolated from the human gut, could restore the microbiota and improve the immunity in the lungs. Indeed, several studies have suggested a connection between the gut and the lungs.

Global Next Generation Probiotics Market: Key Developments

On August 29, 2022, BioGaia, a biotechnology company, developed probiotic products and expanded its product portfolio with new bacterial strains, developed together with its owned subsidiary MetaboGen AB, a biotechnology research company. MetaboGen built a pilot plant in Eslöv, Sweden. The facility handles manufacturing of bacteria with different requirements during fermentation, both traditional lactobacilli as well as new which are extremely oxygen-sensitive strains.

On July 08 2022, A-Mansia Biotech, a privately held biotechnology company, revealed its new brand name along with plans to launch food supplement Akkermansia Muciniphila. The new brand name of A-Mansia Biotech is The Akkermansia Company.

Global Next Generation Probiotics Market: Restraint

Difficulties associated with the production of next-generation probiotics is expected to hinder the growth of the global next generation probiotics market. For instance, according to an article published by Network of Aquaculture Centres in Asia Pacific, an intergovernmental organization that promotes rural development through sustainable aquaculture and aquatic resources management, in 2021, NGP falls under the category of LBPs (live biotherapeutics) or drugs. Any probiotic strain that will be used as NGP is subject to the usual pharmaceutical clinical trials and research on its pharmacokinetics, pharmacodynamics, safety, and delivery routes. This process is stringent and poses significant hurdles on the pathway of NGP development and commercialization.

Global Next Generation Probiotics Market- Key Players

Major players operating in the global next generation probiotics market include Pendulum, Amsterdam Winclove Probiotics, Metabogen AB (Biogaia), Exeliom Biosciences, TargEDys, Chr. Hansen Holding A/S, YSOPIA Bioscience, A-Mansia Biotech, Next Gen Probiotics, Evolve Biosystems, and DuPont de Nemours, Inc.

Next generation probiotics (NGP) or live biotherapeutics are organisms that have been designed to be used as living medicines to treat, cure or diagnose disease. They differ from traditional probiotics in that they are likely to be registered under a drug regulatory framework. At present, conventional probiotics are used as either functional foods or as supplements, whereas next generation probiotics are mainly used as therapeutics and hence are subject to the full range of registration processes and clinical trials.

The next generation probiotics market is expected to gain further traction, with evolving applications which signifies the new genera of probiotics. The well recognized applications of next generation probiotics are drug administration, vaccine delivery, immunomodulation (boosting the immune system), psychobiotics (for the treatment of mental disorders), cancer treatment and prevention, stress tolerance, production of antimicrobial compounds, to understand the pathogenesis of enteric infections.

Market Dynamics

Market players are focused on raising funds from investors for the development of next generation probiotics which is expected to drive market growth over the forecast period. For instance, in May 2019, Whole Biome (now Pendulum), a biotechnology company, announced that it had secured US$ 35 million in Series B financing, which was funded by investor Sequoia Capital, a venture capital company and others. The company had used the funds to advance the commercialization of its patented product, expand its discovery pipeline, and scale clinical trials for their novel microbiome interventions.

Key features of the study:

  • This report provides in-depth analysis of the global next generation probiotics market, and provides market size (US$ Million) and compound annual growth rate (CAGR%) for the forecast period (2022–2030), considering 2021 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends,  regional outlook, and competitive strategies adopted by key players
  • It profiles key players in the global next generation probiotics market  based on the following parameters – company highlights, products portfolio, key highlights, financial performance, and strategies
  • Key companies covered as a part of this study include Pendulum, Amsterdam Winclove Probiotics, Metabogen AB (Biogaia), Exeliom Biosciences, TargEDys, Chr. Hansen Holding A/S, YSOPIA Bioscience, A-Mansia Biotech, Next Gen Probiotics, Evolve Biosystems and DuPont de Nemours, Inc.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
  • The global next generation probiotics market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global next generation probiotics market

Detailed Segmentation:

  • Global Next Generation Probiotics Market, By Bacterial Candidate:
    • Akkermansia
    • Clostridium species
    • Bifidobacterium species
    • Lactobacillus species
    • Others (Faecalibacterium, Christensenella,etc.)   
  • Global Next Generation Probiotics Market, By Application:
    • Weight Management
    • Glucose Management
    • Inflammatory Bowel Diseases
    • Others (Obesity, Metabolic Diseases, etc.)
  • Global Next Generation Probiotics Market, By Region:
    • North America
      • By Country
        • U.S.
        • Canada
    • Latin America
      • By Country
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe
      • By Country
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Country
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East
      • By Country
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Region/Country
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Pendulum
      • Company Highlights
      • Products Portfolio
      • Key Highlights
      • Financial Performance
      • Strategies
    • Amsterdam Winclove Probiotics
    • Metabogen AB (Biogaia)
    • Exeliom Biosciences
    • TargEDys
    • Hansen Holding A/S
    • YSOPIA Bioscience
    • A-Mansia Biotech
    • Next Gen Probiotics
    • Evolve Biosystems
    • DuPont de Nemours, Inc.  

“*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

Global next generation probiotics market size is estimated to be valued at US$ 168.1 million in 2022 and is expected to exhibit a CAGR of 11.2% between 2022 and 2030.
Increasing product launches and research and development activities are expected to drive the market.
Lactobacillus species is the leading bacterial candidate segment in the market.
The major factors hampering growth of the market include Difficulties associated with manufacturing of next generation probiotic products
Major players operating in the market include Pendulum, Amsterdam Winclove Probiotics, Metabogen AB (Biogaia), Exeliom Biosciences, TargEDys, Chr. Hansen Holding A/S, YSOPIA Bioscience, A-Mansia Biotech, Next Gen Probiotics, Evolve Biosystems and DuPont de Nemours, Inc.

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