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Regenerative medicine is a biological heterogeneous domain that incorporates material science, engineering, medicine, biological science and surgery. It acts therapeutically by augmenting and stimulating the body’s capacity for regeneration and self-repair.

Statistics:

The global regenerative medicine (bone and joint) market is estimated to account for US$ 7,189.8 Mn in terms of value in 2020 and is expected to reach US$ 14,990.0 Mn by the end of 2027.

Global Regenerative Medicine (Bone and Joint) Market: Drivers

High prevalence of arthritis is expected to propel growth of the global regenerative medicine (bone and joint) market over the forecast period. For instance, according to the Centers for Disease Control and Prevention (CDC)’s May 2019 report, an estimated 54.4 million US adults have diagnosed arthritis, which accounted for around 1 in 4 people in the U.S.

Moreover, increasing geriatric population is also expected to aid in growth of the global regenerative medicine (bone and joint) market. For instance, according to the U.S. Census Bureau, the U.S. geriatric population is expected to reach 77 million by 2034.   

Statistics:

Biomaterial held dominant position in the global regenerative medicine (bone and joint) market in 2019, accounting for 62.7% share in terms of value, followed by Stem Cell and Tissue Engineering, respectively.

Figure 1. Global Regenerative Medicine (Bone and Joint) Market Share (%), by Value, by Technology, 2019

Regenerative Medicine (Bone and Joint)  | Coherent Market Insights

Global Regenerative Medicine (Bone and Joint) Market: Restraints

Regulatory constraints are expected to hinder growth of the global regenerative medicine (bone and joint) market. Human cellular and tissue based products are considered as biologics. All regenerative medicine products used in bone and joint reconstructive surgeries must meet criteria of good manufacturing practice (GMP) guidelines and good tissue practice (GTP) guidelines. The Office of Cellular, Tissue, and Gene Therapies (OCTGT) of the U.S. FDA regulates and monitors regenerative medicine products in the U.S. OCTGT has the responsibility of monitoring gene therapy, tissue engineering, tissue cellular therapy and cellular gene therapy products.

Moreover, post implant infections and implant failures are also expected to limit growth of the global regenerative medicine (bone and joint) market. Implants have been associated with foreign body-related infections (FBRIs) which increase morbidity and overall cost of treatment for the patient. Staphylococci account for majority of these infections and promote formation of biofilm by adhering to biomaterials.

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Regenerative Medicine (Bone and Joint) Market Report Coverage

Report Coverage Details
Base Year: 2019 Market Size in 2019: US$ 6,473.4 Mn
Historical Data for: 2016 to 2019 Forecast Period: 2020 to 2027
Forecast Period 2020 to 2027 CAGR: 11.1% 2027 Value Projection: US$ 14,990.0 Mn
Geographies covered:
  • North America: U.S., Canada
  • Latin America: Brazil, Argentina, Mexico, Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, Rest of Middle East
  • Africa: South Africa, North Africa, Central Africa
Segments covered:
  • By Technology: Stem Cell, Biomaterial, Tissue Engineering.
  • By Application: Bone Graft Substitutes, Osteoarticular Diseases, Allogeneic Bones, Autogenic Bones, Others.
Companies covered:

Anika Therapeutics, Inc., Arthrex, Inc., Baxter International, Inc., CONMED Corporation, DePuy Synthes, Inc., Medtronic, Plc, Smith & Nephew plc, Stryker Corporation, Zimmer Holdings, Inc., Aziyo Biologics, and Ortho Regenerative Technologies Inc.

Growth Drivers:
  • Technological advancement
  • Increasing prevalence of musculoskeletal disorders
Restraints & Challenges:
  • High Costs

Global Regenerative Medicine (Bone and Joint) Market: Opportunities 

R&D of new products is expected to offer lucrative growth opportunities for players in the global regenerative medicine (bone and joint) market. For instance, Anika Therapeutics, Inc.’s clinical trial for hyalofast, a biodegradable, 3D, hyaluronic acid-based (HA-based) scaffold with autologous bone marrow aspirate concentrate (BMAC) is in the phase III and is expected to be completed in December 2021.

Moreover, high prevalence of bone disorders is also expected to aid in growth of the market. For instance, according to National Center for Biotechnology Information (NCBI), January 2020, incidence of Achilles tendon rupture in the global population is around 5 to 10 per 100,000 people, and it is expected to increase.

The global regenerative medicine (bone and joint) market was valued at US$ 6,473.4 Mn in 2019 and is forecast to reach a value of US$ 14,990.0 Mn by 2027 at a CAGR of 11.1% between 2020 and 2027.

Figure 2. Global Regenerative Medicine (Bone and Joint) Market Value (US$ Mn), and Y-o-Y Growth (%), 2019-2027

Regenerative Medicine (Bone and Joint)  | Coherent Market Insights

Market Trends/Key Takeaways

The regenerative medicine (bone and joint) market in North America is driven by high prevalence of bone related disorders. For instance, according to the World Health Organization, in U.S., by the year 2040, around 78.4 million adults aged 18 years and older will have doctor-diagnosed arthritis, compared to 54.4 million adults in 2013-2015. Moreover, according to the Center for Disease and Prevention (CDC) statistics, 2016, in the U.S, around 5.1% of men and 24.5% of women, both the groups in the age range of 65 years and above were diagnosed with osteoporosis of the femur neck or lumbar spine.

Major players in the global regenerative medicine (bone and joint) market are focused on approval and launch of new products to expand their product portfolio. For instance, in April 2019, the U.S. Food and Drug Administration approved romosozumab (Evenity) for the treatment of osteoporosis in postmenopausal women, who are at a high risk of bone fractures. The medicine works by boosting bone formation in women with a history of osteoporotic fracture or multiple risk factors for fracture, or those who have not benefited from other types of osteoporosis therapies.

Global Regenerative Medicine (Bone and Joint) Market: Competitive Landscape

Major players operating in the global regenerative medicine (bone and joint) market include, Anika Therapeutics, Inc., Arthrex, Inc., Baxter International, Inc., CONMED Corporation, DePuy Synthes, Inc., Medtronic, Plc, Smith & Nephew plc, Stryker Corporation, Zimmer Holdings, Inc., Aziyo Biologics, and Ortho Regenerative Technologies Inc.

Global Regenerative Medicine (Bone and Joint) Market: Key Developments

Major players in the global regenerative medicine (bone and joint) market are focused on expanding marketing and clinical development programs to enhance their market share. For instance, in September 2020, Aziyo Biologics filed for a US$ 57.5 million Nasdaq IPO, with plans to expand its marketing and clinical development programs.

Regenerative medicines are medical products or active pharmaceutical ingredients that have the ability to cure or replace organs and tissues organs damaged by various factors such as aging, diseases, trauma, and can also be used to provide stability in congenital disorders. According to findings of various studies, regenerative medicines can also be useful in treating both chronic and acute disorders in terms various context of abnormalities such as cardiovascular diseases, dermal wounds, and in treatment of certain types of cancer. Furthermore, the current therapy of organ and tissue transplantation for treating organ and tissue failures can result in patient death due to limited or no donor supply and often result in severe complications in immune system. Regenerative medicine helps alleviate such issues to a major extent.

Restraints of the Global Regenerative Medicine (Bone and Joint) Market

Major factors hampering the growth of the regenerative medicine (bone and joint) market during the forecast period constitutes of high costs.

Key features of the study:

  • This report provides in-depth analysis of the global regenerative medicine (bone and joint) market and provides market size (US$ Million) and compound annual growth rate (CAGR %) for the forecast period (2020–2027), considering 2019, as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by leading players
  • It profiles leading players in the global regenerative medicine (bone and joint) market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, strategies, and future plans
  • Key companies covered as a part of this study include Anika Therapeutics, Inc., Arthrex, Inc., Baxter International, Inc., CONMED Corporation, DePuy Synthes, Inc., Medtronic, Plc, Smith & Nephew plc, Stryker Corporation, Zimmer Holdings, Inc., Aziyo Biologics, and Ortho Regenerative Technologies Inc.
  • Insights from this report would allow marketers and the management authorities of companies to make informed decision regarding future product launches, technology up-gradation, market expansion, and marketing tactics
  • The global regenerative medicine (bone and joint) market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts.
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the market.

Detailed Segmentation

  • Global Regenerative Medicine (Bone and Joint) Market, By Technology:
    • Stem Cell
    • Biomaterial
    • Tissue Engineering
  • Global Regenerative Medicine (Bone and Joint) Market, By Application:
    • Bone Graft Substitutes
    • Osteoarticular Diseases
    • Allogeneic Bones
    • Autogenic Bones
    • Others
  • Global Regenerative Medicine (Bone and Joint) Market, By Geography:
    • North America
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country:
        • U.S.
        • Canada
    • Europe
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country:
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country:
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East:
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Technology
        • Stem Cell
        • Biomaterial
        • Tissue Engineering
      • By Application
        • Bone Graft Substitutes
        • Osteoarticular Diseases
        • Allogeneic Bones
        • Autogenic Bones
        • Others
      • By Country/Region:
        • Central Africa
        • South Africa
        • North Africa
  • Company Profiles
    • Anika Therapeutics, Inc.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • Arthrex, Inc.
    • Baxter International, Inc.
    • CONMED Corporation
    • DePuy Synthes, Inc.
    • Medtronic, Plc
    • Smith & Nephew plc
    • Stryker Corporation
    • Zimmer Holdings, Inc.
    • Aziyo Biologics
    • Ortho Regenerative Technologies Inc.

 “*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Technology
      • Market Snippet, By Application
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
    • Impact Analysis
    • Key Developments
    • Regulatory Scenario
    • PEST Analysis
    • COVID-19 Impact Analysis
  4. Global Regenerative Medicine (Bone and Joint) Market, By Technology, 2016 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Stem Cell
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
      • Segment Trends
    • Biomaterial
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
      • Segment Trends
    • Tissue Engineering
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
      • Segment Trends
  5. Global Regenerative Medicine (Bone and Joint) Market, By Application, 2016 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • Bone Graft Substitutes
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Osteoarticular Diseases
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Allogeneic Bones
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Autogenic Bones
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
    • Others
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
  6. Global Regenerative Medicine (Bone and Joint) Market, By Regions, 2016 – 2027 (US$ Mn)
    • Introduction
      • Market Share Analysis, 2019 and 2027 (%)
      • Y-o-Y Growth Analysis, 2017–2027
      • Segment Trends
    • North America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • U.S.
        • Canada
    • Europe
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • U.K.
        • Germany
        • Italy
        • France
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2027, (US$ Mn)
        • North Africa
        • Central Africa
        • South Africa
  7. Competitive Landscape
    • Company Profiles
      • Anika Therapeutics, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Arthrex, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Baxter International, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • CONMED Corporation
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • DePuy Synthes, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Medtronic, Plc
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Smith & Nephew plc
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Stryker Corporation
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Zimmer Holdings, Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Aziyo Biologics
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
      • Ortho Regenerative Technologies Inc.
        • Company Overview
        • Product Portfolio
        • Key Developments
        • Financial Performance
        • Strategies
  8. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 34 market data tables and 23 figures on “Regenerative Medicine (Bone and Joint) Market – Global forecast to 2027.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users