Custom Recombinant Protein Production Service Market, by Product Type (Hormones, Growth Factors, Cytokines, Plasma Protein Factor, Recombinant Metabolic Enzymes, Immune Checkpoint Regulators, and Others), By Application (Drug Discovery & Development, Biopharmaceutical Production, Basic Research, and Others), By End User (Biopharmaceutical Companies, Academic & Research Institutes, Contract Research Organizations, and Others), and Region - Global Industry insights, and Forecast till 2025
- Report code : CMI11516 |
- Industry :
Biotechnology
- Published On : Apr 2018 |
- Pages : 151 Pages |
- Format :
Recombinant Protein Market - Insights
Recombinant proteins are used in development of novel therapies for severe chronic diseases such as cancer and other rare diseases. Recombinant protein production requires a special technique known as recombinant DNA (rDNA) technology. Depending on the type of the protein, recombinant proteins are classified into hormones, growth factor, cytokines, plasma protein factor, recombinant metabolic enzymes, and others. Manufacturers such as Biocon, Ltd., Eli, Lilly, and Company, Genentech, Inc., Novo Nordisk Pharmatech A/S, Prospec-Tany Technogene Ltd., Abcam plc, and BPS Bioscience, Inc. offer recombinant proteins for various applications such as drug discovery and development. Advancements in rDNA technology such as Clustered regularly interspaced short palindromic repeats (CRISPR) technique has complemented recombinant protein production. Furthermore, advancements in associated processes such as protein purification methods, alternative expression technologies, development of alternative cell lines, and enhanced cell culture systems have simplified and optimized the recombinant protein production processes.
Increasing research & development expenditure on biologic drugs is expected to boost demand for recombinant proteins for research purposes
Biopharmaceutical organizations are focusing on research and development of novel biosimilars for life threatening diseases such as cardiovascular diseases, cancer, metabolic disorders such as diabetes, and certain rare conditions such as hemophilia. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested around US$ 58.8 billion in research and development in 2015, of which, majority was by all biopharmaceutical companies in the U.S. Rare disease medical space holds potential as there is relatively low competition. This is owing to less understanding of the disease progression pathways and entities. Therefore, companies could focus on R&D for development of biologics and subsequently biosimilars in this space. Some of the biosimilars available in the market include Eprex, manufactured by Janssen-Cilag Pty Ltd., which has been successful in treatment of anemia. Demand for biosimilars is increasing significantly, owing to high prices of biologics, in turn leading to high demand for recombinant protein.
The global recombinant protein market was valued at US$ 347.2 million in 2016 and is expected to witness a robust CAGR of 6.2% over the forecast period (2017–2025).
Figure 1. Global Recombinant Protein Market Share, by Application (%) 2017 and 2025
Source: Coherent Market Insights Analysis (2017)
Technological advancement in production of recombinant protein is expected to fuel growth of the recombinant protein market
Advancement in technologies in various areas associated with or facilitating recombinant protein production have supported growth of recombinant protein market. For instance, development of alternative expression technologies such as mammalian cell expression, baculovirus expression, and E.coli expression, development of alternative cell lines, and enhanced cell culture systems have simplified and optimized recombinant protein processes. Furthermore, advanced chromatography protein purification methods such as FPLC and HPLC help in providing highly purified clinical grade recombinant proteins. Clustered regularly interspaced short palindromic repeats (CRISPR) technique is a genome editing technique used to target destruction in human cells and can improve recombinant protein production. Moreover, advancements in bioreactor systems have improved the product’s output within shorter time. According to National Centre for Biotechnology Information (NCBI), in 2014, about 65.6% of clinical scale manufacturers and 42% of commercial manufacturers adopted single use bioreactor for improvement in their bioprocessing.
However, factors such as complex manufacturing process, high costs, and requirement of high quality of these products (responsible for high costs) are expected to hinder growth of the market over the forecast period.
Some major players operating in the recombinant protein market include Crown Bioscience, Inc., ProSpec Tany TechnoGene, Ltd., BPS Bioscience, Inc., Sigma Aldrich Company Ltd., Novoprotein Scientific, PeproTech, Inc., Feldan Bio, Inc., BioVision, Inc., HumanZyme, Inc., and GenScript Biotech Corporation.
Recombinant proteins have immense potential in cancer therapy research and development. For instance, growth factors, immune checkpoint, and cell damage & oxidative stress proteins (preclinical stage) are utilized from recombinant proteins category for cancer therapy research. Increased understanding of oncogenic signaling pathways and proteins involved in the same has increased the targeting ways, wherein, recombinant proteins such as immune checkpoint, growth factors, and antibodies are used. These proteins are used extensively by researchers to research cancer signaling pathways and functioning. Recombinant immune checkpoint such as PD-1/PD-L1 Inhibitor 1 and PD-1/PD-L1 Inhibitor 2, which directly targets programmed death-1 (PD-1) and programmed death ligand-1 and 2 (PD-L1) are used for research purposes. Moreover, proteins such as CD226, CD40 Ligand/TRAP, and Human CellExp CTLA4/CD152 are extensively used in cancer therapies research.
Market Dynamics
Increasing demand for recombinant proteins for basic research has supported growth of recombinant protein market. Manufacturers are involved in recombinant protein product innovation in order to improve research outcomes along with improvements in other areas such as expression techniques, and protein purification techniques, which compliments growth of the recombinant protein market. The market is expected to gain significant growth, owing increasing adoption of biologics and biosimilars, which will in turn impact recombinant proteins market, along with rising prevalence of chronic diseases such as cancer. Furthermore, availability of wide number of innovative recombinant proteins from various sources such as human and animal, lack of suitable alternative for basic protein related therapies research, and increasing demand for biological products is expected to fuel growth of the market
Key features of the study:
- This report provides in-depth analysis of recombinant protein market and provides market size (US$ Million) and Cumulative Annual Growth Rate (CAGR %) for the forecast period (2017–2025), considering 2016 as the base year
- It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
- This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, regional outlook, and competitive strategy adopted by the leading players
- It profiles leading players in the global recombinant protein market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, and strategies
- Key companies covered as a part of this study include Crown Bioscience, Inc., ProSpec Tany TechnoGene, Ltd., BPS Bioscience, Inc., Sigma Aldrich Company Ltd., Novoprotein Scientific, PeproTech, Inc., Feldan Bio, Inc., BioVision, Inc., HumanZyme, Inc., and GenScript Biotech Corporation
- Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launches, technology up-gradation, market expansion, and marketing tactics
- The global recombinant protein market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
- Stakeholders would have ease in decision-making through the various strategy matrices used in analyzing the recombinant protein market
Detailed Segmentation:
- Global Recombinant Protein Market, By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- Global Recombinant Protein Market, By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- Global Recombinant Protein Market, By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- Global Recombinant Protein Market, By Geography:
- North America
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- U.S.
- Canada
- Europe
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- China
- India
- Japan
- ASEAN
- Australia
- South Korea
- Rest of Asia Pacific
- Latin America
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- Brazil
- Mexico
- Rest of Latin America
- Middle East
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- GCC
- Israel
- Rest of Middle East
- Africa
- By Product Type:
- Hormones
- Growth Factor
- Cytokines
- Plasma Protein Factor
- Recombinant Metabolic Enzymes
- Immune Checkpoint Regulators
- Others
- By Application:
- Drug Discovery & Development
- Biopharmaceutical Production
- Basic Research
- Others
- By End User:
- Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
- By Country:
- Central Africa
- South Africa
- North Africa
- Company Profiles
- Crown Bioscience, Inc.*
- Company Overview
- Product Portfolio
- Financial Performance
- Key Strategies
- Recent Developments
- ProSpec Tany TechnoGene, Ltd.
- BPS Bioscience, Inc.
- Sigma Aldrich Company Ltd.
- Novoprotein Scientific
- PeproTech, Inc.
- Feldan Bio, Inc.
- BioVision, Inc.
- HumanZyme, Inc.
- GenScript Biotech Corporation
- Crown Bioscience, Inc.*
“*” marked represents similar segmentation in other categories in the respective section.
Table of Contents
- Research Objective and Assumption
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Product Type
- Market Snippet, By Application
- Market Snippet, By End User
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Drivers
- Restraints
- Market Opportunities
- PEST Analysis
- PORTER’s Analysis
- Global Recombinant Protein Market, By Product Type, 2015–2025 (US$ Mn)
- Introduction
- Market Share Analysis, 2016 and 2025 (%)
- Y-o-Y Growth Analysis, 2016–2025
- Segment Trends
- Hormones
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Growth Factor
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Cytokines
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Plasma Protein Factor
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Recombinant Metabolic Enzymes
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Immune Checkpoint Regulators
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Global Recombinant Protein Market, By Application, 2015–2025 (US$ Mn)
- Introduction
- Market Share Analysis, 2016 and 2025 (%)
- Y-o-Y Growth Analysis, 2016–2025
- Segment Trends
- Drug Discovery & Development
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Biopharmaceutical Production
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Basic Research
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Global Recombinant Protein Market, By End User, 2015–2025 (US$ Mn)
- Introduction
- Market Share Analysis, 2016 and 2025 (%)
- Y-o-Y Growth Analysis, 2016–2025
- Segment Trends
- Biopharmaceutical Companies
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Academic & Research Institutes
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Contract Research Organizations
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2015–2025, (US$ Mn)
- Global Recombinant Protein Market, By Region, 2015–2025 (US$ Mn)
- Introduction
- Market Share Analysis, By Region, 2016 and 2025 (%)
- Y-o-Y Growth Analysis, For Regions, 2016–2025
- North America
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- U.S.
- Canada
- Europe
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- China
- India
- Japan
- ASEAN
- Australia
- South Korea
- Rest of APAC
- Latin America
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- Brazil
- Mexico
- Rest of Latin America
- Africa
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- Central Africa
- South Africa
- North Africa
- Middle East
- Market Size and Forecast, By Product Type, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Application, 2015–2025 (US$ Mn)
- Market Size and Forecast, By End User, 2015–2025 (US$ Mn)
- Market Size and Forecast, By Country, 2015–2025 (US$ Mn)
- GCC
- Israel
- Rest of Middle East
- Competitive Landscape
- Heat Map Analysis
- Company Profiles
- Crown Bioscience, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- ProSpec Tany TechnoGene, Ltd.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- BPS Bioscience, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Sigma Aldrich Company Ltd.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Novoprotein Scientific
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- PeproTech, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Feldan Bio, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- BioVision, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- HumanZyme, Inc.
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- GenScript Biotech Corporation
- Company Overview
- Product Portfolio
- Key Developments
- Financial Performance
- Strategies
- Section
- References
- Research Methodology
- About us and Sales Contact
*Browse 39 market data tables and 40 figures on "Recombinant Protein Market - Global forecast to 2025”.
Research Methodology
Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:
- Primary Research (Trade Surveys and Experts Interviews)
- Desk Research
- Proprietor Data Analytics Model
In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.
Coherent Market Insights desk research is based on a principle set of research techniques:
- National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
- Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.
Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:
- Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
- Trade association, National and international media and trade press.
- Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
- Scientific journals, and other technical magazines and whitepapers.
Preliminary Data Mining
The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.
Data Standardization:
Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.
Coherent Statistical model
We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:
- Micro-economic indicators
- Macro-economic indicators
- Environmental indicators
- Socio-political indicators
- Technology indicators
Data Processing
Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.
Data Validation
This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:
- It provides first-hand information on the market dynamics, outlook, and growth parameters.
- Industry experts validates the estimates which helps the company to cement the on-going research study.
- Primary research includes online surveys, face-to face interviews, and telephonic interviews.
The primary research is conducted with the ecosystem players including, but not limited to:
- Raw Material Suppliers
- Manufacturers
- System Integrators
- Distributors
- End-users
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