Alveolar rhabdomyosarcoma (ARMS) is a type of soft tissue sarcoma that originates from the connective tissues of the body such as bone, muscle, cartilage, and ligaments. According to the survey by Children’s Oncology Group, 2011, alveolar rhabdomyosarcoma makes up about 25-40% of RMS. ARMS is mostly detected in adolescents and often occurs on the arms, legs, chest, and stomach. The exact cause of alveolar rhabdomyosarcoma is unknown, however it is associated with other conditions such as Neurofibromatosis type 1, Beckwith-Wiedemann syndrome, Li-Fraumeni syndrome, Cardio-facio-cutaneous syndrome, and Costello syndrome. The methods for diagnosis of ARMS include examination such as X-ray imaging, CT scan, MRI, bone scan, ultrasound, PET scan, and a biopsy, in order to plan a suitable treatment for the condition. ARMS is a type of high-grade tumor meaning it cells are characterized by rapid growth and faster progression.

According to the Surveillance, Epidemiology, and End Results (SEER) database, ARMS constitutes 23% of patients among the types of RMS. Also, alveolar rhabdomyosarcoma needs more-intensive therapy than embryonal rhabdomyosarcoma. Radiation therapy including intensity-modulated radiotherapy (IMRT) and proton beam radiation therapy are implemented as an effective way to shrink the tumor cells post chemotherapy. Mostly, chemotherapy and radiation therapy is used to shrink the size of the tumor before surgery and to minimize the risk of cancer reoccurrence post-surgery.

Alveolar Rhabdomyosarcoma Treatment Market: Market Dynamics

Rising incidence of alveolar rhabdomyosarcoma along with technological advancements in radiation therapy is expected to augment market growth of alveolar rhabdomyosarcoma treatment. According to the survey by the University of Minnesota, 2014, soft tissue sarcomas (STS) comprises about 7% of all malignancies in children and adolescents under the age of 20 years and rhabdomyosarcoma (RMS) accounts for about 40% of pediatric STS. The incidence of RMS is 4.5 cases/million children/adolescents per year, where ARMS comprises 31% of RMS and in 50% cases the condition is highly prevalent below the age of 10. Also, latest advancements in radiation therapy, which are largely adopted by major hospitals such as Mayo Clinic, Memorial Sloan Kettering Cancer Center include proton beam therapy program that provides highly targeted precision beams to destroy cancerous cells by sparing the healthy surrounding tissues.

Moreover, various government and non-government organizations are undertaking research initiatives to improve the outcomes of alveolar rhabdomyosarcoma as the condition is associated with lower survival rates. Several clinical trials are conducted by large international cooperative groups, such as Soft Tissue Sarcoma Committee of the Children's Oncology Group (COG) and the National Comprehensive Cancer Network (NCCN) to provide innovative treatments based on latest research, which in turn is expected to bolster market growth in the forecast period. Also, researchers at Oregon Health & Science University Doernbecher Children's Hospital have identified a promising new approach to overcoming drug resistance and increase the survival rate in children with alveolar rhabdomyosarcoma. According to the Oregaon Health and Science University, 2011, the survival rate among alveolar rhabdomyosarcoma patients after extensive therapy is less than 20%.

Organizations and manufacturers are conducting clinical trials to investigate novel therapies to treat pediatric cancers. For instance, in 2015, Novartis Pharmaceuticals initiated the Phase 1 study for Trametinib in combination with Dabrafenib in children and adolescents with alveolar rhabdomyosarcoma harboring V600 mutations.

Alveolar Rhabdomyosarcoma Treatment Market: Regional Dynamics

Regional segmentation of the global alveolar rhabdomyosarcoma treatment market by Coherent Market Insights comprises North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to hold a dominant position in the global alveolar rhabdomyosarcoma treatment market over the forecast period, owing to rising number of initiatives undertaken by organizations in the region to develop potential therapies, increasing research and development, and adoption of advanced radiation therapies. Organizations in the region have initiated the first molecular targeted drug in a clinical trial in 2011, for childhood muscle cancer at the Doernbecher Children's Hospital and Children Oncology Group (COG) sites. Also, St. Baldrick’s Foundation works in collaboration with pediatric oncologists and funds supportive cancer research to develop promising research to positively impact treatment of children with cancer. Moreover, other organization such as the National Cancer Institute, Scott Carter Foundation, Alex's Lemonade Stand Foundation, and the Hyundai Hope on Wheels Program have funded various studies, in order to explore highly potential therapeutic options. The alveolar rhabdomyosarcoma treatment market in Asia Pacific is expected to witness high growth, owing to rising awareness of the disease in the regions supported by advancements in the medical settings to adopt novel therapies.

Alveolar Rhabdomyosarcoma Treatment Market: Competitive Analysis

Key players operating in the global alveolar rhabdomyosarcoma treatment market include Eli Lilly and Company, GlaxoSmithKline Plc., Boehringer Ingelheim GmbH, Bristol-Myers Squibb, F. Hoffmann-La Roche AG, Oasmia Pharmaceutical, Celgene Corporation, Pfizer, Inc., and Johnson & Johnson Services, Inc.

Alveolar Rhabdomyosarcoma Treatment Market: Market Taxonomy

On the basis of therapy type, the global alveolar rhabdomyosarcoma treatment market is segmented into:

  • Chemotherapy
  • Radiation Therapy
  • Combination Therapy

On the basis of end user, the global alveolar rhabdomyosarcoma treatment market is segmented into:

  • Hospitals
  • Specialty Clinics
  • Ambulatory Surgical Centers

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users