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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Androgens are male sex hormones responsible for masculine characteristics such ad muscular build, deeper voice, and facial hair. Most of the androgens are produced in testes and their two most common types are dihydrotestosterone (DHT) and testosterone. Along with normal functions, androgens also contribute to prostate cancer cell growth, especially during early stages of the cancer. Androgen deprivation therapy, also called androgen suppression therapy, is used either to reduce the production of androgens in the patient’s body or to modulate the way androgens work, thus ultimately inhibiting growth of prostate cancer cells.

Androgen Deprivation Therapy (ADT) Market Drivers

Key players in the market are focusing on research to develop new drugs and broaden the indication label of current drugs for treatment of androgen deprivation therapy (ADT), which is expected to boost the global androgen deprivation therapy (ADT) market growth over the forecast period.

For instance, in February 2018, Janssen Pharmaceutica, a subsidiary of Johnson & Johnson received approval for its drug ERLEADA (apalutamide) in treatment of non-metastatic castration-resistant prostate cancer (CRPC). ERLEADA is a next-generation androgen receptor inhibitor, which belongs to the class of drugs anti-androgens and blocks the effect of testosterone to slow down the process of tumor growth and metastasis. It is the first U.S. Food and Drug Administration (FDA) approved drug for the treatment of patients with non-metastatic CRPC.

Similarly, in July 2018, Pfizer Inc. and Astellas Pharma Inc. received approval from the U.S. FDA for XTANDI (enzalutamide) that is indicated for the treatment of non-metastatic CRPC along with its existing indication for CRPC. XTANDI is an androgen receptor inhibitor and works by inhibiting the effects of testosterone, thereby slowing tumor growth and metastasis. These factors are expected to have a positive impact on the global androgen deprivation therapy (ADT) market growth over the forecast period.

Androgen Deprivation Therapy (ADT) Market Regional Analysis

Approval for new drugs is expected to boost the global androgen deprivation therapy (ADT) market growth over the forecast period. For instance, in November 2017, European Commission (EC) granted approval to Janssen-Cilag International NV (Janssen) for broadening the existing marketing authorization for its drug Zytiga (abiraterone acetate). The approval enables the company to include the drug in treatment of metastatic prostate cancer’s early stages along with ADT. Such new drug approvals are expected to propel Europe androgen deprivation therapy (ADT) market growth over the forecast period.

Androgen Deprivation Therapy (ADT) Market Restraints

According to American Cancer Society (ASC), several prostate cancers, which are treated with ADT develop resistance to the treatment over a period of time (few months or years). Hormone therapy is not useful in treating hormone refractory prostate cancer i.e. cancer, which is no longer responding to hormone therapy. According to National Cancer Institute (NCI), National Institutes of Health (NIH), along with prostate, androgens also contribute to functions of other organs. Therefore, hormone deprivation therapy is associated with side effects such as hot flashes, loss of bone density, erectile dysfunction, lowered libido, loss of muscular strength mass, insulin resistance, and change in blood lipids, fatigue, mood swings, weight gain and gynecomastia. These factors are expected to restrain the global androgen deprivation therapy (ADT) market growth over the forecast period.

Androgen Deprivation Therapy (ADT) Market Key Players

Some of the major players operating in the androgen deprivation therapy (ADT) market include, Pfizer Inc., Astellas Pharma Inc., Johnson & Johnson, Novartis International AG, Veru Inc., Sanofi S.A., GlaxoSmithKline plc, Bayer AG, Orion Corporation, and AstraZeneca Plc.   

Androgen Deprivation Therapy (ADT) Market Taxonomy

The global androgen deprivation therapy (ADT) market is segmented on the basis of drug class, route of administration, distribution channel, and regions. 

By Drug Class

  • Antiandrogens
    • Flutamide
    • Bicalutamide
    • Nilutamide
    • Enzalutamide
  • Luteinizing hormone-releasing hormone (LHRH) agonists
    • Leuprolide
    • Goserelin
    • Triptorelin
    • Histrelin
  • LHRH antagonist
    • Degarelix
    • Abiraterone
  • Others

By Route of Administration

  • Oral
  • Injectable

By Distribution Channel

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

By Region

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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