Enquiry IconContact Us
CMI Logo

Deferiprone is an FDA approved drug that is majorly used to treat transfusion-dependent thalassemia and a wide range of disorders. Deferiprone is a type of hydroxypyridinone iron chelator that was synthesized by Dr. Kontoghiorghes in the early mid-1980s. Iron is essential for the survival of almost all species. When the body is under primary iron overload condition (hemochromatosis) or secondary condition (transfusion-dependent thalassemia), due to lack of iron excretion mechanism, massive accumulation of possibly toxic substances is experienced, followed by iron-induced early death. Deferiprone drug works by binding the iron chelator with ferric ions (iron III), forming a stable complex, which is further eliminated in the urine. Selectivity of deferiprone is more towards iron than other metals such as copper, aluminum, and zinc. Deferiprone are available in the market in various dosage form such as tablets, oral solutions, and capsules. According to FDA 2015 prescribing information, the initial recommended dose for deferiprone is 25 mg, orally, three times per day for a total of 75 mg/day. Adjustment of the dose should be personalized to the individual therapeutic goals (maintenance or reduction of body iron burden) and patient’s response to the treatment. The maximum dose is 33 mg/kg, three times per day for a total of 99 mg/day.

Deferiprone Market Dynamics

Rising incidence of hemochromatosis globally, is propelling growth of the deferiprone market. For instance, according to the American Diabetes Association website, hereditary hemochromatosis is the most widespread single-gene disease among western populations, affecting roughly 1 out of every 200 to 300 people. Moreover, rising prevalence of transfusion-dependent thalassemia among the population is significantly expected to propel demand for deferiprone. For instance, according to the World Health Organization 2008 bulletin, around 1.1% of couples worldwide are at risk for having children with a hemoglobin disorder and 2.7 per 1,000 conceptions record this disorder. However, adverse reactions such as agranulocytosis, chromaturia, nausea, vomiting, and abdominal pain related with the use of deferiprone is expected to hamper the deferiprone market growth. Furthermore, increasing healthcare initiatives and funding by government and private agencies is expected to boost growth of the deferiprone market. For instance, according to the article published in PLOS One Journal 2017, UAE government adopted a new nationwide campaign to indorse the premarital screening in 2008. Since its inception, the premarital screening has been mandatory for all married couples in the UAE, which provide information about the risk of conceiving a child suffering from thalassemia

Deferiprone Market – Regional Insights

On the basis of region, the global deferiprone market is segmented into North America, Europe, Latin America, Asia Pacific, Middle East, and Africa. North America holds the major market share in the global deferiprone market, owing to better medical facilities, high adoption of innovative products, and rising awareness among the populace in the region. Moreover, increased government support for the population is propelling growth of the deferiprone market in the region. For instance, according to study published in the American Journal of Public Health 2016, the U.S. government spending on healthcare accounted for US$ 5,960 per capita, highest of any country in 2013. Innovative development is increasing the healthcare availability to the populace in Asia Pacific, as pharmaceutical manufacturing companies are increasingly investing in the region, thus propelling growth of the deferiprone market in Asia Pacific. For instance, In 2014 Cipla an Indian multinational pharmaceutical and Biotechnology Company, invested around US$ 99,045,000 for research and development.

Deferiprone Market – Competitive Landscape

The two major players operating in the deferiprone market are Apotex and Cipla Limited. Key market player are engaged in adopting various growth strategies such as mergers, collaborations, acquisition, and introduction of new products in order to strengthen their position in the global market. For instance, in 2016, Cipla limited completed its US$ 550-million acquisition of generic drug key manufactures, Exelan Pharma and InvaGen. This acquisition is expected to boost Cipla Limited’s U.S. business, by providing Cipla with 32 marketed products, 40 approved abbreviated new drug applications (ANDAs), and a pipeline of 30 products, which are expected to be approved in the near future.

Deferiprone Market – Taxonomy

On the basis of type, the global deferiprone market is segmented into:

  • Tablets
  • Oral Solutions
  • Capsules

On the basis of application, the global deferiprone market is segmented into:

  • Transfusional Iron Overload
  • NTDT Caused Iron Overload

On the basis of distribution channel, the global deferiprone market is segmented into:

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

On the basis of geography, the global deferiprone market is segmented into:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

Subscribe Newsletter

Kindly subscribe for our latest news & articles.