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Focal Segmental Glomerulosclerosis (FSGS) is a rare kidney disease affecting the kidney's filtering system (glomeruli) and resulting in serious scarring and end stage renal disease. For instance, according to the article in Clinical Journal of American Society of Nephrology, 2017, FSGS incidence rates are often higher in men, an estimated 1.5-fold higher as compared to women. FSGS is characterized by symptoms such as edema, proteinuria, weight gain, increased cholesterol, and proteins in blood.

Focal Segmental Glomerulosclerosis Market – Drivers

As there is no drug approved for the treatment of FSGS yet. Thus, limited treatment therapy and government funding for research on rare diseases are expected to drive growth of the FSGS market. For instance, in 2015, the U.S. Food and Drug Administration (FDA) and European Commission both granted Sparsentan, as orphan drug designation for the treatment of FSGS. This Sparsentan is a novel drug candidate with dual mechanism of action combines angiotensin receptor blockade with endothelin receptor blockade and is currently being evaluated in a Phase III trial, which expected to complete in December 2022.

Increasing research and development for FSGS drugs by various manufacturers is also fueling growth of the FSGS market. For instance, Pfizer Inc., is undergoing clinical trial for the evaluation of its drug, PF-06730512 in adults with primary focal segmental glomerulosclerosis. This drug is currently in Phase II study and is expected to complete in June 2021.

Moreover, government investments into the rare disease treatment is expected to drive the growth of market. For instance, according to an annual data report from the U.S. Renal Data System 2017, Medicare invested around US$ 34 billion for people on dialysis with chronic kidney disease.

Focal Segmental Glomerulosclerosis Market – Restraint

Lack of awareness among population regarding this disease and high cost of dialysis therapy may restrict growth of this market to some extent. For instance, according to an article published in University of Michigan 2017, awareness among patients with FSGS is considerably low when the patients are in primary stage of FSGS, which is hampering growth of the FSGS market.

Focal Segmental Glomerulosclerosis Market – Regional Analysis

On the basis of region, the global focal segmental glomerulosclerosis market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to dominate the FSGS market due to high prevalence of FSGS along with chronic kidney diseases. For instance, According to an annual data report by the U.S. Renal Data System 2017, the overall burden of kidney disease, kidney failure with dialysis, and kidney transplantation is highest in U.S., thus driving the growth of the focal segmental glomerulosclerosis market.

Asia Pacific region is expected to witness significant growth in market due to collaboration agreements and partnerships among various players. For instance, Oraxion Therapeutics, Inc., a subsidiary of Indian company Aten Porus, is undergoing preclinical and efficacy study of the drug, ORX-301, which can be used in the treatment of FSGS. In February 2018, Oraxion Therapeutics, Inc., entered into an Option Agreement with the U.S-based Biopharmaceutical Company and under this agreement, U.S. based company gets exclusive rights for further clinical studies and license of this drug in the U.S.

The key players operating in the focal segmental glomerulosclerosis (FSGS) market include GlaxoSmithKline plc., Novartis AG, Variant Pharmaceuticals, Inc., ChemoCentryx, Inc., Retrophin, Inc., AbbVie, Inc., Pfizer, Inc., AstraZeneca plc., Sanofi S.A,  and Teva Pharmaceutical Industries Ltd.

Focal Segmental Glomerulosclerosis Market – Taxonomy

By Disease Type

  • Primary Focal Segmental Glomerulosclerosis
  • Secondary Focal Segmental Glomerulosclerosis

By Drug

  • Sparsentan (Phase III)

By Distribution channels

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

By Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users