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Peptide drugs are potential therapeutic agent used against several disease attributing to its features high activity, target specificity, low toxicity, and minimal non-specific or drug–drug interactions. The low physicochemical properties such as poor membrane permeability and low target specific action when administered orally demands for improved peptide drug. Glycosylation of peptides is a promising strategy to modulate the physicochemical properties of peptide drugs and for penetration of peptides across biological membranes. Glycosylation of a peptide can be of two type N-linked glycosylation or O-linked glycosylation. Glycosylation of peptide drug enhances bioactivity, selectivity and prolong half-life of therapeutic drug. Advantages offered by glycosylated peptide over conventional peptide drug are the key factor driving growth of the glycosylated peptide market. For instance, Amgen’s Aranesp is used for treatment of anemia associated with chronic renal failure (CRF), having 5 N-linked oligosaccharide chain, which has three fold longer half-life as compared to Epogen, a 3 N-linked oligosaccharide chain. Furthermore, product approvals, inorganic strategies by key players, and various application of glycosylated peptide are some of the factors driving growth of the glycosylated peptide market.

Glycosylated Peptide Market – Driver

New product launches by the key manufacturers are fueling growth of the glycosylated peptide market. For instance, in 2017, Pfizer Inc., received the U.S. Food and Drug Administration (FDA) approval for Ixifi (infliximab-qbtx), a chimeric human-murine monoclonal antibody, as a treatment for patients with rheumatoid arthritis, Crohn's disease, pediatric Crohn’s disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. Furthermore, in Feb 2017, CT-P10 received approval from the European Commission and in June 2017, it was approved by U.S. FDA. Furthermore, Sumsung Bioepis’s Infliximab biosimilar candidate SB2 got Ministry of Food and Drug Safety approval for Korea in 2016, European Commission approval for Europe in 2016, Therapeutic Goods Administration (TGA) approval for Australia in 2016, US FDA approval in 2017 and Health Canada (HC) approval of Canada in 2017. Moreover, company received European Commission (EC), Ministry of Food and Drug Safety (MFDS) and TGA approval for its Adalimumab biosimilar, SB5 in 2017 and 2018. However, challenges associated with the biosimilar product approval and stringent regulatory policies are restraining growth of the glycosylated peptide market.

Moreover, market players involved in the glycosylated peptide market are adopting strategies such as merger and acquisition for expanding geographical coverage or product portfolio. For instance, in 2014, Bachem AG, a peptide manufacturer and GlyTech Inc., a glycosylated drug developer, entered into co-promotional agreement for GlyTech’s glycosylation technology. The agreement will leverage Bachem by enhancing its sales and marketing resources and GlyTech to promote Bachem for manufacturing of its glycopeptides and glycoproteins. Moreover, in 2016, Teva Pharmaceutical Industries, Israel-based global pharmaceutical company, entered into commercial partnership with Celltrion Inc., a Korean based Biopharmaceutical company to commercialize two of Celltrion’s monoclonal antibody (mAb) biosimilar, CT-P10 (mAb biosimilar to Rituximab) candidates in the U.S. and Canada. The commercial partnership with Celltrion will enable Teva to strengthen its position in biosimilar products and Celltrion to expand its product to global market.

Increasing application of glycosylated peptide is expected to fuel growth of the glycosylated peptide market. For instance, in 2015, Sussex Research Laboratories Inc., a specialist in glycodesign and the synthesis of complex carbohydrates, announced successful clinical trials for Glycolastin, anti-aging glycopeptide cosmetic active. The in-vitro studies for comparing efficacy of Glycolastin against non-glycosylated peptide reported increased secretion of structural protein elastin, fibronectin, and collagens by fibroblast. Furthermore, company plans to commercialize Glycolastin, as a cosmetic active in topical anti-aging products.

Glycosylated Peptide Market - Regional Analysis

On the basis geography, the glycosylated peptide market is segmented into North America, Latin America, Europe, Middle East, Asia Pacific, and Africa. North America is expected to hold dominant position in glycosylated peptide market over the forecast period, owing to increasing FDA approved products in the region. Asia Pacific is expected to witness significant growth due to emerging market players and their market expansion strategies. For instance, in 2017, Amgen collaborated with Simcere Pharmaceutical Group for co-development and commercialization of its biosimiliar products along with its four undisclosed pipeline biosimilar products for the treatment of inflammation and oncology in China.

Glycosylated Peptide Market – Competitor

Major players operating in glycosylated peptide market include Pfizer Inc., Teva Pharmaceutical Industries Ltd., Bachem Holding AG, GlyTech, Inc., Sussex Research Laboratories Inc., Samsung Bioepis, and Celltrion Inc.

Glycosylated Peptide Market - Taxonomy

By Product

  • Monoclonal Antibodies (mAbs)
  • Erythropoietin (EPO)
  • Other Products

By Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
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Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users