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Lyme disease is an infectious disease, caused due to the bacterium – Borrelia burgdorferi, which is transmitted to humans through bites of infected adult black-legged ticks. Most human infections are caused by bites of nymphs (immature tick). Ticks can attach to any part of the human body and can transmit the infection, if attached to the host body for 36 to 48 hours. Blacklegged ticks are responsible for spreading Lyme disease in the northeastern, mid-Atlantic, and north-central areas of the U.S. However, western black-legged ticks spread Lyme disease in the regions along the Pacific Coast. These regions are thus, expected to witness rapid growth of the market for Lyme disease treatment in the near future.

The early symptoms associated with Lyme disease include fever, headaches, chills, fatigue, muscle and joint aches, swollen lymph nodes, and characteristic skin rash (erythema migrans). According to the Centers for Disease Control and Prevention (CDC), erythema migrans affects around 70% to 80% of infected people, worldwide. However, untreated Lyme disease can lead to further discomfort, which includes intermittent pain in muscles, tendons, joints, and bones, coupled with severe headaches, neck stiffness, arthritis with severe joint pain, swelling in knees, facial palsy, increased heart palpitations or an irregular heartbeat, nerve pain, and inflammation of the brain and spinal cord. 

Lyme carditis is a rare complication in Lyme disease, which occurs when infection invades the tissue of the heart. This can interfere with normal heart rhythm resulting in mild, moderate, or severe heart blockage. Patients may experience palpitations, lightheadedness, blackouts, chest pain, and dyspnea. According to the National Surveillance Data, done by National Notifiable Disease Surveillance System (NNDSS), between 2001 and 2010, Lyme carditis affected around 1% of patients suffering from Lyme disease, in the U.S. Lyme carditis can be treated with intravenous or oral antibiotics, preferably ceftriaxone. However, some patients might require implantation of a temporary or permanent pacemaker, depending upon the severity of infection.

Antibiotics are found to be the most effective treatment for Lyme disease. Patients with early stages of Lyme disease recover rapidly and completely with appropriate antibiotics such as doxycycline, amoxicillin, and cefuroxime axetil. Patients with certain neurological or cardiac illness may be treated with intravenous ceftriaxone. Patients bearing chronic symptoms of Lyme disease for over 6 months, can recover within a few weeks, through oral antibiotic treatment.

According to International Lyme and Associated Disease Society (ILADS), Lyme disease is often difficult to diagnose and treat, resulting in persistent infections.  ILADS recommends individualized treatment based on the severity of symptoms, tick-borne coinfections, and patient’s response to treatment. However, no single antibiotic or combination of antibiotics appears to be capable of eliminating the Lyme disease infection. Therefore, the prevailing cases of Lyme disease and large scope to develop the ideal antibiotic for treatment, are expected to boost the Lyme disease treatment market in the near future.  

However, prolonged exposure to antibiotics could possibly wipe out beneficial intestinal flora, leading to various health problems. This, in turn, is expected to impose a threat to growth of the Lyme disease treatment market.  

The U.S. Food and Drug Administration (FDA), in July 2017, granted fast track designation to the first vaccine for Lyme disease – VLA15, created by Valneva SE – a Europe-based biotech firm, which is engaged in producing commercial vaccines for travelers. The company plans to initiate the phase 2 studies in early 2018. Introduction of new vaccine are further expected to drive growth of the Lyme disease treatment market. 

Lyme Disease Treatment Market Taxonomy:

By disease type:

  • Early Lyme disease (absence of erythema migrans)
  • Lyme carditis
  • Lyme arthritis
  • neurologic Lyme disease
  • Borrelial lymphocytosis
  • Post-treatment Lyme Disease Syndrome (PTLDS)

By treatment:

  • Doxycycline
  • Amoxicillin
  • Cefuroxime axetil
  • Ceftriaxone
  • Others (azithromycin, clarithromycin, erythromycin)

Increasing incidence to drive the Lyme disease treatment market in North America

Globally, North America accounts for largest share of the market, owing to the highest number of Lyme disease cases reported here. According to Centers for Disease Control and Prevention (CDC), around 28,453 confirmed cases of Lyme disease and 9 new cases per 1,00,000 people were recorded in the U.S. during the 2005 - 2015. The European market is also expected to experience rapid growth in the Lyme disease treatment market in near future. According to the 2014 factsheet of European Centre for Disease Prevention and Control (ECDC), prevalence of Lyme disease is steadily increasing.  

The major players operating in the Lyme disease treatment market include Lupin Ltd, Mylan N.V., Sun Pharmaceuticals Industries Ltd., Pfizer Inc., G&W Laboratories, Inc., Teva Pharmaceutical Industries Ltd., Sandoz AG, GlaxoSmithKline plc., and Hospira Inc.


Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users