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Ascites is the condition characterized by formation of excessive fluid in the abdominal cavity, particularly in the peritoneal cavity. It causes when the body is unable to eliminate out fluids. When ascites is developed due to cancer, it is called as malignant peritoneal effusion or malignant ascites. Malignancies that are most commonly associated with malignant ascites are cancers of breast, liver, ovary, lungs, lymphoma, and colon. In ascites condition, lymph glands in the body gets blocked and lead to ascites symptoms including low blood pressure, loss of sleep, fatigue, and skin problems. Key symptoms in malignant ascites are abdominal pain or discomfort, shortness of breath, swelling of the abdomen, leg or ankle swelling, constipation, and weight gain. Diagnosis of ascites can be done by ultrasound, x-ray test, CT scans, and physical examination. The survival rate of these patients is very low, although with suitable treatment such as paracentesis, chemotherapy, and surgeries are available. Various conventional treatment for malignant ascites include chemotherapy, shunting, paracentesis, and use of drugs such as spironolactone and spironolactone. Cirrhosis of the liver is the most common cause of ascites but other conditions such as kidney failure, heart failure, cancer or infection can also cause ascites.

Malignant Ascites Treatment Market – Dynamics

Rising prevalence of cirrhosis is a major factor for growth of the malignant ascites market. For instance, according to a study published in World Journal of Gastroenterology 2011, over 50% of patients develop ascites within 10 years diagnosis. According to a published article in Journal of Clinical and Translational Hepatology 2014 showed advancements in ascites condition is related with poor prognosis, with a mortality of 15% at one year and 44% at the five year follow up. Moreover, favorable reimbursement policies like 2010 Patient Protection and Affordable Care Act (PPACA) and increasing incidence of cancer are also propelling the market growth. For instance, according to 2018 American Cancer Society report, cancer was responsible for 609,640 deaths in the U.S. Furthermore, key company adopt market strategies such as acquisition are propelling the market growth, For instance, 2016 NanoAntibiotics acquired LAT Pharma LLC, an early-stage biotechnology company famous for developing new medicines to treat life-threatening complications of liver cirrhosis.

However, stringent regulations and complications associated with ascites treatment such as internal bleeding after paracentesis treatment, exposure of radiation in chemotherapy may hinder growth of the market over the forecast period. For instance, According to report published in 2017 Experimental & Molecular Medicine showed that radiation can induce toxicities in non-tumorous liver tissues that may limit the course of therapy or have serious chronic side effects, including late fibrosis.

Malignant Ascites Treatment Market – Regional Insights

On the basis of region, malignant ascites treatment market is segmented into North America, Europe, Latin America, Asia Pacific, Middle East, and Africa. North America accounts for the largest share in the global malignant ascites treatment market size, owing to high healthcare expenditure, well-developed technology, and increasing prevalence of cirrhosis are accelerating growth of the malignant ascites treatment market in this region. For instance, according to study published in 2015 Journal of Clinical Gastroenterology showed prevalence of cirrhosis in the U.S. was approximately 0.27%, corresponding to 633,323 adults.

Moreover, Asia Pacific is expected to witness significant growth in the market over the forecast period, owing to increasing prevalence of cirrhosis. For instance, according to a study published in 2015 BMJ Open Gastroenterology, hospitalization from viral hepatitis cirrhosis decreased by 10% between 2006 to 2010, however, non-viral hepatitis cirrhosis and alcoholic cirrhosis exhibited an increase of 35% and 33% in China.

Malignant Ascites Treatment Market – Competitive Landscape

Key players operating in the global malignant ascites treatment market include PharmaCyte Biotech Inc., Sequana Medical, Fresenius SE & Co. KGaA, BioVie, BD, Medtronic plc, and GI Supply, Actavis Elizabeth LLC, Mylan Pharmaceuticals Inc., GE Healthcare, Trion Pharma, Siemens AG, and Fresenius Biotech. Major players are focused towards adopting strategies such as collaboration, and increasing R&D funding to strengthen their product portfolio and retain their position in the market, For instance, BioVie’s Lead Compound BIV201 received FDA Orphan-Drug Designation for the treatment of ascites in 2016

Malignant Ascites Treatment Market – Taxonomy

On the basis of treatment type, malignant ascites treatment market is segmented into:

  • Therapeutic Treatment
  • Surgical Treatment

On the basis of application, malignant ascites treatment market is segmented into:

  • Ovarian Cancer
  • Breast Cancer
  • Gastrointestinal Cancer
  • Colorectal Cancer
  • Carcinoma of Unknown Primary
  • Others

On the basis of geography, malignant ascites treatment market is segmented into:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users