Mantle cell lymphoma is a rare type of blood cancer, which occurs due to excessive growth of lymphocytes. Mantle cell lymphoma is one of the B-cell non-Hodgkin lymphoma, which occurs as a result of formation of tumors in the lymph nodes, which enters the blood and spreads to the bone marrow, digestive tract, spleen, and liver. Common symptoms of the disease include loss of appetite, weight loss, fever, nausea, and vomiting. The type of treatment for a patient suffering from mantle cell lymphoma depends on various factors such as the stage of disease, age, and overall health of the patient. In 2012, the U.S. Food and Drug Administration (FDA) approved a supplemental new drug application for bortezomib (Velcade), which updates the existing label to include subcutaneous method of administration for the treatment of mantle cell lymphoma (MCL) patients who have received at least one prior therapy.

Rising prevalence of mantle cell lymphoma is expected to accelerate growth of the mantle cell lymphoma treatment market over the forecast period

Major factors driving growth of the mantle cell lymphoma market are rising prevalence of mantle cell lymphoma and increasing research and development activities in the healthcare sector resulting in a promising product pipeline. According to the study by Drug Development Technology, 2017, an estimated 3,300 new cases of mantle cell lymphoma are diagnosed every year in the U.S. The mantle cell lymphoma treatment market is expected to gain significant traction with the approval from the federal agencies. For instance, in October 2017, AstraZeneca received approval for Calquence under the FDA’s accelerated approval pathway for the treatment of adults with mantle cell lymphoma. Also, development of targeted agents with low toxicity profiles for the treatment of relapsed mantle cell lymphoma in combination with approved drugs is a major factor augmenting the mantle cell lymphoma treatment market growth. However, serious side effects of the drugs such as anemia, neutropenia, and diarrhea are the factors restraining growth of the mantle cell lymphoma treatment market.

The global mantle cell lymphoma treatment market is segmented on the basis of therapy type, route of administration, end user, and geography.

On the basis of therapy type, the global mantle cell lymphoma treatment market is segmented into:

  • Chemotherapy
  • Monoclonal Antibody Therapy
  • Targeted Therapy
  • Radiotherapy
  • Stem Cell Treatment

On the basis of route of administration, the global mantle cell lymphoma treatment market is segmented into:

  • Intravenous
  • Oral

On the basis of end user, the global mantle cell lymphoma treatment market is segmented into:

  • Hospitals
  • Clinics
  • Ambulatory Surgical Centers

Accelerated approval pathway program by the U.S. FDA is expected to propel the mantle cell lymphoma treatment market in North America

Regional segmentation of the mantle cell lymphoma treatment market by Coherent Market Insights comprises North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to be dominant in the global market over the forecast period. This is owing to increasing incidence rate of the disease in the region. According to the Leukemia and Lymphoma Society, 2014, about 70,800 new cases of cases of non-Hodkin Lymphoma were registered in the U.S., where mantle cell lymphoma represented about 6% or 4,200 cases of the total cases. Also, the FDA’s Center for Drug Evaluation and Research Agency works with manufacturers to analyze drug development, approval, promising the Breakthrough Therapy Destination Program to make treatments available for patients with rare disease. For instance, in 2013, the FDA approved Imbruvica (ibrutinib), manufactured by Janssen Pharmaceuticals, Inc. as a breakthrough therapy destination to treat patients with mantle cell lymphoma (MCL), a rare and aggressive type of blood cancer. Asia Pacific is expected to witness high growth rate in the mantle cell lymphoma treatment market over the forecast period owing to rising government initiatives, rise in research and development to curb the disease.

Key players operating the market include:

Key players are offering products to cater to unmet needs in patients with relapsed or refractory mantle cell lymphoma. For instance, Kite Pharma, Inc. is focused on developing engineered autologous T cell therapy products for the treatment of cancer. In 2015, the company initiated Phase 2 clinical study of KTE-C19 in patients with relapsed or refractory mantle cell lymphoma.

Key players operating in the global mantle cell lymphoma treatment market include F.Hoffman La Roche Ltd., Abbvie, Inc., Kite Pharma, Inc., Bayer AG, Bristol-Myers Squibb Company, Celgene Corporation, Eli Lilly and Company, GlaxoSmithKline Plc, Amgen, Inc., Gilead Sciences, Inc., and Johnson and Johnson.


Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users