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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Nitrous oxide (also called laughing gas) is a colourless gas or a liquefied compressed gas. Taking nitrous oxide delivery systems can cause feelings of euphoria, relaxation and calmness, fits of giggles and laughter – hence the nickname 'laughing gas'.  It has a slightly sweetish taste and a pleasant odour. It is slightly soluble in water and found naturally in the air as part of the earth's normal nitrogen cycle. Nitrous oxide is widely used in medical and non-medical applications. In the medical industry, it is widely used in surgery and dentistry procedures as an analgesic and anesthetic. According to the American Dental Association, nitrous oxide delivery systems is a safe and effective sedative agent when used with oxygen in dentistry procedures. It does not intend to make induce sleep, therefore patients can hear and see during the dentistry procedures. In the non-medical industry, nitrous oxide delivery systems is used as a propellant to make whipped cream sold at supermarket at around US$ 10 for a box of ten canisters, and is used as an engine lubricant in the automotive industry.

Global Medical Nitrous Oxide Delivery Systems Market – Drivers

Wide application of nitrous oxide delivery systems in medical and non-medical industry is expected to drive growth of the global medical nitrous oxide delivery systems market. Nitrous oxide is a prominent gas in medicinal industry due to its use in surgery and dentistry procedures as anaesthesia and analgesic agent.  Nitrous oxide with its prominent applications in medical field has increased investment by various companies dealing with medicinal gases, which is boosting the growth of the global medical nitrous oxide delivery systems market. For instance, according to Gas World, in 2013 the new SEDARA gas mixer system from Linde Therapeutic Solutions is a fixed-concentration of nitrous oxide delivery systems/oxygen (N2O/O2) therapy innovation in over 20 years. Use of nitrous oxide delivery systems gases in non-medical industries has also been facilitating growth of the medical nitrous oxide delivery systems market.

Global Medical Nitrous Oxide Delivery Systems Market– Impact of COVID–19 Analysis

Governments and healthcare experts across the globe are focused on developing a durable vaccine against COVID–19. The clinical outcome of inhaled nitric oxide gas and BCG immunotherapy has proved effective and may be a potential treatment against coronavirus. Several device companies have recently received the FDA’s permission to use nitric oxide in emergency situations for treating COVID–19. During the SARS outbreak in 2003, inhalation of nitric oxide improved lung oxygenation. In addition to improving lung function, nitric oxide also showed anti-viral activity. Thus pulmonary vasodilator effect and a direct antiviral effect of nitrous oxide delivery systems towards COVID–19 infected patients may prove effective.

Global Medical Nitrous Oxide Delivery Systems Market – Restraints

The major factor restraining the growth of the medical nitrous oxide delivery systems market is stringent rules and regulation over the possession, transport and use of nitrous oxide delivery systems. Centre for Drug Evaluation and Research and the U.S. Food and Drug Administration regulate the use of medical gases and their associated equipment and the guidelines regulated by them specify the use and administration of nitrous oxide delivery systems.

Health workers who are exposed to nitrous oxide delivery systems for a long period of time can suffer from skin allergy. According to the United States Environmental Protection Agency, in 2018, nitrous oxide delivery systems (N2O) accounted for about 6.5% of all U.S. greenhouse gas emissions from human activities such as agriculture, fuel combustion, wastewater management, and industrial processes (medical and non-medical) which increasing the amount of N2O in the atmosphere. These factors are expected to restrain the global medical nitrous oxide delivery systems market growth during the forecast period.

Global Medical Nitrous Oxide Delivery Systems Market – Regional Analysis

On the basis of region, the global medical nitrous oxide delivery systems market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is projected to dominate global medical nitrous oxide delivery systems market during forecast period owing to investments in research and development. For instance, the U.S. National Library of Medicine in 2016 stated that the New York City Health and Hospitals Corporation completed clinical trial on high-concentration continuous flow nitrous oxide delivery systems use for procedure-induced pain or anxiety during dentistry and surgery procedures. Key players in the region are Praxair Technology, Inc. and Matheson Tri-Gas, Inc.

Moreover, the growing prevalence of heart disease, pulmonary disease, diabetes in Europe is expected to favor growth of the market during forecast period. Advancements in research and development are also driving the growth of the market in Europe. For instance, according to the EU Clinical Trial Register, in 2016, Air Liquide Santé International initiated the study of equimolar mixture of oxygen and nitrous oxide delivery systems (EMONO) for the treatment of peripheral neuropathic pain, a randomised, international, multicentre, placebo–controlled, phenotype–stratified and completed its phase IIa. Key players in the region are Air Liquide S.A, SOL SpA, and Merck KGaA.

Furthermore, Asia pacific is expected to witness significant growth in the medical nitrous oxide delivery systems market due to wide applications of nitrous oxide delivery systems in medical and non-medical industries. Asia Pacific is home to industries in various sectors such as electronics, pharmaceutical. In 2015, The Messer Group GmbH, a supplier of industrial gases, commissioned its new US$ 37.41 million, specialty gas plant in Suzhou, eastern China.

Key players in region are Taiyo Nippon Sanso Corporation, Promas Engineers Pvt. Ltd, and S.S. Gas Lab Asia Pvt. Ltd.

Global Medical Nitrous Oxide Delivery Systems Market– Competitive Landscape

Key players operating in global medical nitrous oxide delivery systems market are Praxair Technology, Inc, Matheson Tri–Gas, Inc, Air Liquide S.A, SOL SpA, Merck KGaA, Taiyo Nippon Sanso Corporation, Promas Engineers Pvt. Ltd, S.S. Gas Lab Asia Pvt. Ltd, Linde plc, Oxygen & Argon Works Ltd, and Bellerophon Therapeutics.

Key Developments–

  1. In March 2020, U.S. Food Drug Administration (FDA) granted emergency expanded access to ‘Bellerophon Therapeutics’ inhaled nitric oxide delivery system for treating the novel coronavirus.
  2. In January 2020, Shanghai Showa Electronics Materials’ new facility which is to be built adjacent to its current factory, will produce high purity nitrous oxide delivery systems and high purity octafluorocyclobutane gases. The factor is expected to start operations in the second half of 2021.
  3. In 2018, African Oxygen Limited (Afrox) signed a new state healthcare contract from October 2017 to September 2022 , the healthcare contract includes providing  the supply of a range of medical and other gases including oxygen, nitrogen, nitrous oxide delivery systems, carbon dioxide, hydrogen, helium, argon, gas mixtures and refrigeration gases, besides others across South Africa. Moreover, contract also specified that, Afrox will supply range of medicinal and other gases to more than 400 hospitals and 1600 clinics across South Africa.
  4. In 2017, Linde EOX Sdn Bhd, a subsidiary of Linde Malaysia Sdn Bhd and a member of The Linde Group, collaborated with Jabatan Kesihatan Negeri Sarawak (JKNS) to provide medical gases and upgrades related to facilities to all public hospitals in the state of Sarawak, Malaysia.

Global Medical Nitrous Oxide Delivery Systems Market– Taxonomy–

By Product Type–

  • Gas Canisters
  • Tanks
  • Cylinders
  • Bottles
  • Accessories
  • Others

By Application–

  • Obstetric Use
  • Dental Use
  • Emergency Use
  • Anaesthetic Use
  • Recreational Use

By End User–

  • Hospitals
  • Dental Clinics
  • Ambulatory Surgical Centres
  • Others

By Region–

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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