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Nasal delivery is a choice of treatment or drug delivery for the topical treatment of nasal diseases and paranasal sinuses like sinusitis and allergic rhinitis. Moreover, the nasal route is considered in some cases over the normal oral route owing to rapid absorption and needle-free drug delivery with the effect as desired. Hence, it is also one of the preferred routes for needle-free vaccination and systemic drug delivery. Moreover, this route helps addressing issues related to poor bioavailability, slow absorption, drug degradation and adverse events in the gastrointestinal tract. Atomized nasal medications rapidly absorb across mucosal membranes into the bloodstream, avoiding first-pass metabolism. However, during nasal delivery one needs to take care to protect the delicate lungs from hazardous exposures. Medication in liquid form can be administered via nasal route through inhalers, spray pumps, droppers, nebulizers or atomizers. In atomizers the medication exits the tip as a fine atomized mist resulting in broad coverage of the nasal mucosal with a thin layer of drug.

Nasal Atomizer Device Types

Nasal atomizers are currently used in the treatment of allergic rhinitis and sinusitis. These devices usually are multi-dose products enabling long-term usage of the device. The nasal atomizers are classified based on the technology/mechanics as gas propelled or electrical. The air or gas controlled technique involves the use of squeezed bottle which when pressed releases the content out of the small nozzle in definite volume. The dose delivered however is highly dependent on the pressure applied while squeezing the bottle. An electronic atomizer on the other hand is devised to release only a defined amount of medication from the nozzle. This makes the use of device more convenient for patients at home.

Kurve Technology had designed and developed a nasal drug delivery device called ViaNase in 2004 that used a controlled particle dispersion method. During that period, Kurve’s technology was the only known technique that delivered chemical formulations via the nose to the paranasal sinuses in clinical testing. Moreover, Kurve’s technology was also designed to be used with multiple drugs.

Accurate Dosing is Essential in Atomization

Since then there have been many new devices being introduced in the market with improving dosage accuracy. Accurate dosing is essential in a nasal atomization device to circumvent any side effects due to overdose. Recently in November 2016, Teleflex Medical Corporation recalled its MAD Nasal Intranasal Mucosal atomization device which contained drug to reverse the action of opioid overdose. The device was recalled on the warning that it may not deliver the proper dose of the drug naloxone hydrochloride. This drug with the device is extensively used by the policemen and firefighters in the U.S.

The market still in its nascent stages of adoption is experiencing increasing acceptance in the developed regions of North America and Europe. However, creating awareness among the healthcare professionals and patients is essential for acceptance of this novel technology. Increasing self-medication trend can be leveraged upon for penetrating the global nasal drug delivery devices market.

Major market players include DeVilbiss Healthcare, Teleflex Incorporated, and Kurve Technology, etc. Being a niche segment of drug delivery, there exists a lot potential for manufacturers of nasal drug delivery systems.

Key Developments

Increasing availability of drug in the form of a nasal atomizer is expected to boost the market growth. For instance, Naloxone, a drug known to reverse the effects of an opioid overdose, was made available online in Louisiana, in the form of a nasal atomizer. It was made available on, a website by Script Health, a Public Benefit Corporation.

Research on use of nasal devices is expected to offer growth opportunities for market players. For instance, according to a study from the National Institute on Drug Abuse (NIDA), March 2019, improvised nasal naloxone devices commonly used by first responders and the general public deliver significantly less naloxone than regulator-approved devices.

Major companies are also focused on gaining contracts to enhance their market share. For instance, in May 2019, Kurve Technology, developer of ViaNase electronic atomizer, won the U.S. Department of Defense’s contract for testing a new formulation in combatting traumatic brain injuries.


Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users