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Oligonucleotides are short DNA or RNA molecules and have specific sequence of nucleotide residue, which makes an entire molecule. Oligonucleotides readily bind in specific sequencing manner to their respective DNA-RNA oligonucleotide to form duplex chain. Oligonucleotides are chemically synthesized molecular chains with phosphoramidites components of natural or chemically modified nucleosides and have wide range of applications in generic testing, research, and forensic.

Global Oligonucleotide Synthesis Market - Drivers

Research institutes and diagnostic centers have shifted their focus on genomics and genetics due to their high efficiency, which has increased demand for high quality synthesized oligonucleotides in the market over the past few years. For instance, in July 2020, researchers of Rosalind Franklin University of Medicine and Science initiated a new therapeutic approach for treating Batten disease, a fatal neurodegenerative disease in children, with the help of antisense oligonucleotides. These factors are expected to drive the global oligonucleotide synthesis market growth.

Global Oligonucleotide Synthesis Market - Impact of COVID-19

The coronavirus pandemic has affected each and every market globally. There has been increasing demand for effective treatment against COVID-19. Presently, pharmaceutical companies and healthcare providers are focused on discovering more efficient use of oligonucleotides and its application to prevent the spread of COVID-19. For instance, in 2020, Innovative Genomic Institute stated that they are working on aerosolized locked nucleic acid modified antisense oligonucleotide that can be inhaled or nebulised for treatment of COVID-19 infections. Such innovations are generating an interest amongst healthcare providers and stimulating them to fight against COVID-19 pandemic. Thus, COVID-19 has affected the global oligonucleotide synthesis market in a positive way.

Global Oligonucleotide Synthesis Market - Restraints

Natural oligonucleotides are composed of ribose or deoxyribose sugar phosphate as a base, which are quickly degraded in the body by nucleus, so they are not much effective. Moreover in generic testing, oligo-degradation can affect cell growth and cause proliferation. Furthermore, low quality of microarray generated oligonucleotide sequence is a major challenge in adopting microarray technology for oligonucleotide synthesis. These factors are expected to restrain the global oligonucleotide synthesis market growth.

Global Oligonucleotide Synthesis Market - Regional Analysis

On the basis of region, the global oligonucleotide synthesis market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is expected to experience significant growth due to the presence of better pharmaceutical infrastructure and increasing use of oligonucleotides by pharmaceutical companies. Moreover, biotechnological companies are focusing on research and development in order to increase their market share in the global oligonucleotide synthesis market. For instance, in 2019, Integrated DNA Technology, a biotechnological company in the U.S., launched ‘oPools- oligo pools’, a pool of high quality DNA oligonucleotides with 350 nucleotides in length.

Moreover, Asia Pacific region comprises fast growing life science market and has greater focus on research in genetics and genomics, and its applications. Biotechnological companies are focusing on expanding their manufacturing facilities due to increasing demand for oligonucleotides from pharmaceutical companies. For instance, in March 2020, STA pharmaceuticals, a subsidiary of WuXi AppTech, announced inauguration of its large scale oligonucleotide active pharmaceutical ingredient manufacturing facility in China.

Global Oligonucleotide Synthesis Market - Competitive Landscape

Key players operating in the global oligonucleotide synthesis market include Thermo Fisher Scientific, Integrated DNA Technologies, Inc, Sigma-Aldrich Corporation, GE Healthcare, TriLink BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, and Shanghai SynTheAll Pharmaceutical Co., Ltd.

Key Developments-

  1. In 2019, Twist Biosciences, a biotechnological company in the U.S., launched its long oligonucleotide with 300 nucleotides sequence to increase the productivity of biological research
  2. In 2018, Corden Pharma GmbH (Germany) expanded its new oversea commercial oligonucleotide active pharmaceutical ingredient manufacturing facility at CordenPharma Colorado in the U.S., which will help to grow network in Europe and U.S.

Global Oligonucleotide Synthesis Market - Taxonomy

  • By Product Type
    • Probe
    • Linkers
    • Adaptor
    • Drugs
    • Reagent
    • Equipment
  • By Application
    • Research
    • Diagnostic
    • Therapeutics
  • By End User
    • Research Institutes
    • Biotechnology Companies
    • Pharmaceutical Companies
  • By Region
    • North America
    • Latin America
    • Europe
    • Asia Pacific
    • Middle East
    • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users