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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Orexin (hypocretin) is a neuropeptide produced by the lateral hypothalamus which regulates the wakefulness, appetite, arousal and other habits. Orexin receptor antagonist is the new class of drugs are used in the treatment of insomnia.  

Suvorexant, is a dual orexin receptor antagonist drug that blocks both pathways of OX1R and OX2R. It develops sleep by the binding inhibition of orexin A and B, neuropeptides that promote wakefulness. Approximately 70,000 orexin neurons are present in the human brain, located in the perifornical lateral hypothalamus, which send signals throughout the brain and spinal cord.

Global Orexin Receptors Antagonist Market Drivers

The main growth driver for the Orexin receptors antagonist market is the rising cases of insomnia. Insomnia is caused by plenty of reasons such as anxiety, stress and depression. Lifestyle problems can trigger insomnia like irregular sleeping patters, drinking alcohol and smoking tobacco products before going to bed. Rising geriatric population, increased stress levels in urban population also results into insomnia. According to American Academy of Sleep Medicine AASM) as reported in 2014  insomnia affects 30% of adults, 15-20% have short term insomnia and 10% of adults have chronic insomnia worldwide.

Growing awareness about insomnia and penetration of Belsomra into the market is expected to create more demand in ORA market.  Moreover, studies are being conducted whether suvorexant can be used to treat depression and anxiety so that the ORA market can witness further growth.

Global Orexin Receptors Antagonist Market Restraints

Though suvorexant (Orexin Receptors Antagonist) is the best drug available against insomnia, other classes of drugs such as Benzodiazepines, Non-benzodiazepines, Antidepressants, Melatonin Antagonist and medical devices like 2Breathe Sleep Inducer, Sleep Shepherd Blue, Dreem Headband, Fisher Wallace Stimulator, SR1 Delta Sleeper can also be used to treat insomnia which can negatively impede the market growth. Moreover, in National Sleep Foundation (NSF) stated that in the year 2010 only 15% of people were diagnosed with insomnia and only 6% receive the treatment for the same. General negligence among the people about insomnia and the side effects of drugs such as headache, sleepiness, next day drowsiness, weight loss restricts the patients from using this medication.

Furthermore, clinical studies by NCBI in 2015 showed the placebo treatment for insomnia is also effective for the patients which hampers the growth of ORA market.

Global Orexin Receptors Antagonist Market Regional analysis

North America is leading the Orexin receptors antagonist market. Rising demand for insomnia treatment in the U.S. and Canada coupled with increase in awareness, and high healthcare spending are anticipated to drive the market. Moreover, high prevalence of insomnia among geriatric population in the U.S. are expected to increase the demand. According to AASM in 2017 30-50% population of U.S. over the age of 60 has developed insomnia.

In Asia Pacific, China is expected to show lucrative growth in the market owing to high prevalence of insomnia. According to China National Knowledge Interne (CNKI) in 2017 15% of China’s population is suffering from insomnia aging 43 and above From the Journal of Community Medicine & Health Education as reported in 2017 in India 72% of population above the age of 60 has insomnia. Asia Pacific is anticipated to witness significant growth in near future because of shift-work disorder and increasing stress level is expected to increase the number of paitents in Asia Pacific. In addition, favorable reimbursement policies for therapeutic products, strong product pipeline, and rising stress level are other reasons contributing to the growth.

Global Orexin Receptors Antagonist Market Key Players

Key competitors in the global Orexin receptors antagonist market include Merck & Co. Inc., Sanofi, Pfizer, Inc., Takeda Pharmaceutical Company Ltd., Purdue Pharmaceuticals L.P., Eisai, Co. Ltd., Meda Consumer Healthcare Inc., Pernix Therapeutics, Vanda Pharmaceuticals, and ECR Pharmaceuticals.

Global Orexin Receptors Antagonist Market Taxonomy

 By Application

  • Insomnia
  • Depression and Anxiety

By Dosage

  • 5mg
  • 10mg
  • 15mg
  • 20mg

By Geography

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East
  • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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