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Phase-Xs | Biologics & Biosimilars | Coherent Market Insights

Pertuzumab is a recombinant monoclonal antibody that acts as an antineoplastic agent, which targets the human epidermal growth factor receptor 2 protein known as HER2. The drug blocks signaling pathways that leads to cell growth arrest and apoptosis (cell destruction), thereby inhibiting the proliferation of human tumor cells. Pertuzumab was found to aid in the treatment of HER2 associated breast cancer and was developed by Genentech, Inc., a subsidiary of F. Hoffmann-La Roche AG. It was first approved by U.S. Food and Drug Administration in 2012.

Pertuzumab Market– Drivers

There are increasing number of clinical trials for use of pertuzumab in combination with other drugs for the treatment of breast cancer . For instance, Helsinki University Central Hospital is undergoing phase III clinical study for adjuvant trastuzumab, pertuzumab, and docetaxel in the treatment of early HER2 positive breast cancer. The study was started in December 2015 and is estimated to complete by June 2023.

Furthermore, increasing number of drug approvals are expected to propel growth of the global pertuzumab market. For instance, in December 2017, the U.S. Food and Drug Administration (U.S FDA) granted approval to PERJETA, a pertuzumab produced by Genentech, Inc. for its use in combination with trastuzumab and chemotherapy as adjuvant treatment of patients with HER2-positive early breast cancer at high risk of recurrence.

Moreover, development of novel anticancer drug delivery technologies is expected to boost growth of the market. For instance, in July 2018, Gentech, Inc., in partnership with Halozyme Therapeutics, Inc., used proprietary ENHANZE drug-delivery technology of Halozyme Therapeutics, Inc., for subcutaneous administration of fixed-dose combination of pertuzumab (PERJETA) and trastuzumab (Herceptin). This study is under clinical phase III trial. ENHANZE technology aids in reducing the need for multiple injections and reduces time required for drug administration.

Pertuzumab Market– Restraint                                                

Increasing cost of anticancer drugs is expected to be a major factor hampering growth of the market. For instance, in June 2017, The Scottish Medicines Consortium (SMC) denied access to pertuzumab in England, which was available via the Cancer Drugs Fund (CDF) in Europe. The drug was rejected by SMC as the treatment of HER2 positive breast cancer was not cost effective when pertuzumab was used in combination with trastuzumab and docetaxel.

Moreover, according to a study published in the journal Oncology, September 2015, although the use of pertuzumab with docetaxel and trastuzumab as first-line therapy for HER2 positive breast cancer has been shown to yield a substantial survival benefit, the therapy is not cost effective in the U.S. Also, according to the same source, the cost of treating HER2 positive breast cancer with pertuzumab and other drugs is US$ 509,845 and that with only docetaxel and trastuzumab is US$ 135,092.

Pertuzumab Market– Regional Analysis

On the basis of region, the global pertuzumab market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to hold dominant position in the global pertuzumab market due to increasing prevalence of breast cancer among women in the U.S. For instance, according to American Cancer Society 2017, around 52,710 new cases of invasive breast cancer were diagnosed in 2017 among women in the U.S. and around 40,610 women were expected to die due to breast cancer in the U.S. in same year.

Furthermore, Asia Pacific is expected to witness significant growth in the global pertuzumab market, owing to increasing awareness of breast cancer and its management. For instance, in November 2016, India launched National Cancer Screening Program to increase awareness and early detection of breast cancer. This framework aims to offer mechanism for effective screening and management of common cancers.

Pertuzumab market – Competitive Analysis

Key players operating in the global pertuzumab market include, Halozyme Therapeutics, Inc. and F. Hoffmann-La Roche Ltd.

Pertuzumab Market Taxonomy:

  • By Indication
    • Early Breast Cancer
    • Metastatic Breast Cancer
  • By Distribution Channel
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
  • By Region
    • North America
    • Europe
    • Asia Pacific
    • Latin America
    • Middle East
    • Africa

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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