Tardive dyskinesia (TD) is a form of dyskinesia that is difficult to treat. It is a nerve disorder characterized by involuntary movements such as jaw, lips, and tongue, considered as grimacing, sticking the tongue out, and lip smacking. Some other symptoms are an individual experiencing involuntary movement of the lower and upper extremities and also breathing choking. According to Center for Drug Evaluation and Research, tardive dyskinesia can lead to disability and can further stigmatize patients with mental illness. Tardive akathisia, a type of tardive dyskinesia, involves acute pain, inner tension, anxiety, and a compulsive drive to move the body. Tardive dyskinesia usually occurs in patients who are under prolong administration of antipsychotic drugs for any neurological disorder such as depression, psychosis, and certain drugs to treat gastrointestinal disorders. In spite of various studies conducted by pharmaceutical companies to know the exact treatment mechanism for tardive dyskinesia, only one drug developed by Neurocrine Biosciences that has received approval. Strong pipeline drugs for treatment of TD disorder are expected to propel growth of the tardive dyskinesia drugs market.

Increasing incidence of neurological disorders to drive growth the Tardive Dyskinesia Drugs Market

According to Mental Health America, the occurrence of tardive dyskinesia is estimated to be 10 to 20% of patients who are earlier treated with long term anti-psychotic medications. According to Neurocrine’s Chief Medical Officer, Chris O’Brien, all doctors and psychiatrists now accept Tardive dyskinesia as a prevalent condition. However, according to Neurocrine Bioscience, there are still an estimated 500,000 people in the U.S., who are affected by Tardive Dyskinesia each year. Lack of awareness on TD and its medication can hinder growth of global tardive dyskinesia drugs market.

Valbenazine to gain the major market share in TD Drugs Market globally

The global tardive dyskinesia drugs market is segmented on the basis of the sub-types, drugs, end user, and geography. On the basis of sub-type, the global market is divided into choreoathetosis, tardive dystonia, blepharospasm, and tardive akathisia. On the basis of drugs, the Global Market is divided into Valbenazine, Tetrabenazine, and others (deutetrabenazine and VMAT2 inhibitor). On the basis of end user, the global market is divided into hospitals, pharmacies, drug stores, and e-commerce.

Increased use of long-term neuroleptic drugs increases the risk of tardive dyskinesia, which proportionally boost the tardive dyskinesia drugs market

Regional segmentation in TD Drugs Market by Coherent Market Insights comprises North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. North America accounts for the largest share in tardive dyskinesia drugs industry.  For instance, according to Virtual Medical Center, Australia, tardive dyskinesia is observed in around 15-30% of patients in the U.S. who have been prescribed with long-term neuroleptic drugs administration. Patients with mood disorders such as depression, anxiety disorders, and bipolar affective disorder are at greater risk of developing tardive dyskinesia as compared to people suffering from schizophrenia. The symptoms of tardive dyskinesia will remit within 3 months of stopping neuroleptic drugs for 1 in 3 patients with tardive dyskinesia. Thus, the increase in prevalence of mental disorders would boost the tardive dyskinesia drugs market growth.

Strong clinical trial pipeline to treat Tardive Dyskinesia is expected to boost the market for Tardive Dyskinesia Drugs Market in near future   

Key players operating in the tardive dyskinesia market include Valeant Pharmaceuticals, Neurocrine Biosciences, and Teva Pharmaceutical Industries. There are quite a few companies in Tardive Dyskinesia Market, which are striving hard to understand the mechanism to treat dyskinesia and are constantly working towards developing innovative drugs in order to provide accurate test results. Teva pharmaceutical is also conducting clinical trials of deutetrabenazine for tardive dyskinesia that were started by Auspex Pharmaceutical in 2015.

Key Developments

  1. Major companies in the market are focused on various growth strategies such as gaining product approvals from regulatory authorities, in order expand their product portfolio. For instance, in April 2017, Neurocrine Biosciences, Inc., a biopharmaceutical company, received the U.S. Food and Drugs Administration approval for Ingrezza capsules, which are indicated for the treatment of adults suffering from tardive dyskinesia.
  2. Key players in the market are involved in various business strategies such as gaining product approvals from regulatory authorities, in order to enhance their market presence. For instance, in August 2017, Teva Pharmaceutical Industries received the U.S. FDA approval for AUSTEDO tablets, which is indicated for the treatment of patients suffering from tardive dyskinesia.       

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.

Data Triangulation Methodology | Coherent Market Insights

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

Market Analysis | Coherent Market Insights

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
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  • Distributors
  • End-users