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  • Published In : Oct 2023
  • Code : CMI4398
  • Pages :156
  • Formats :
      Excel and PDF
  • Industry : Pharmaceutical

The global alagille syndrome treatment market is estimated to be valued at US$ 88.9 Million in 2023 and is expected to exhibit a CAGR of 6.6% during the forecast period (2023-2030).

Analysts’ Views on the Global Alagille Syndrome Treatment Market:

Alagille syndrome is one of the rarest forms of liver disease, and most patients go untreated due to lack of effective treatment. The lack of effective treatment leaves patients with limited options for managing their symptoms and improving their quality of life. Patients with Alagille syndrome often experience a range of symptoms including liver damage, heart problems, and developmental issues. The absence of effective treatment not only hampers their ability to alleviate these symptoms but also makes it challenging for healthcare professionals to provide comprehensive care and support for these patients. Without effective treatment, patients with Alagille syndrome may face a lifetime of complications and difficulties. The absence of options to manage their symptoms not only impacts their physical health but also takes a toll on their emotional well-being, highlighting the urgent need for further research and development in this field.

Figure 1. Global Alagille Syndrome Treatment Market Share (%), By Drug, 2023

ALAGILLE SYNDROME TREATMENT MARKET

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Global Alagille Syndrome Treatment Market - Drivers

  • Increasing interest by researchers and key market palyers : There is an increase in interest among researchers and key market players to explore Alagille syndrome treatment options more effectively. This is primarily due to its potential to significantly improve the quality of life of patients and address unmet medical needs in this rare genetic disorder. Alagille syndrome is a complex condition that affects multiple organ systems including the liver, heart, and kidneys. As current treatment options are limited and often focused on managing symptoms, there is a growing urgency to develop innovative therapies that can target the underlying cause of the syndrome. By advancing research in this area, researchers and market players aim to provide hope for patients and their families by offering more effective and tailored treatment approaches. These therapies could potentially improve the quality of life for individuals with Alagille syndrome and reduce the need for invasive procedures such as liver transplants. Additionally, by understanding the underlying cause of the syndrome, researchers may be able to identify potential biomarkers or genetic targets that could lead to earlier diagnosis and intervention.

Figure 2. Global Alagille Syndrome Treatment Market Share (%), By Region, 2023

ALAGILLE SYNDROME TREATMENT MARKET

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Global Alagille Syndrome Treatment Market - Regional Analysis

Among regions, North America is estimated to hold a dominant position in the global alagille syndrome treatment market over the forecast period. North America is estimated to hold 39.73% of the market share in 2023. The global alagille syndrome treatment market is expected to witness significant growth in the coming years, driven by the high prevalence of Alagille syndrome. The exact prevalence rate of Alagille syndrome in North America is not known, but researchers are working to determine it. Alagille syndrome is considered a rare genetic disorder that affects multiple organ systems, making it challenging to accurately estimate its prevalence. However, ongoing research efforts are focused on gathering data and conducting comprehensive studies to determine the exact prevalence rate of Alagille syndrome in North America. These efforts involve collaboration between medical professionals, researchers, and patient advocacy groups to ensure a thorough understanding of the disorder's occurrence. By obtaining accurate prevalence data, healthcare providers can better allocate resources and develop targeted interventions for individuals with Alagille syndrome in North America.

Global Alagille Syndrome Treatment Market - Impact of Coronavirus (COVID-19) Pandemic

  • Since the COVID-19 virus outbreak in December 2019, the disease spread to over 100 countries across the globe, and the World Health Organization (WHO) declared it a public health emergency on January 30, 2020.
  • COVID-19 affected the economy in three main ways: by directly affecting the production and demand of drugs, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries, such as China, India, Saudi Arabia, the U.A.E., Egypt, and others, are facing problems with the transportation of things from one place to another.

Global Alagille Syndrome Treatment Market Segmentation:

The global alagille syndrome treatment market report is segmented into drug, distribution channel, and region.

  • By drug, the market is segmented into ursodeoxycholic acid, cholestyramine, rifampicin, late stage pipeline drugs, and others. Out of which, ursodeoxycholic acid is expected to hold a dominant position in the global alagille syndrome treatment market during the forecast period, and this is attributed to the increasing ursodeoxycholic acid use for the development of new drugs to treat alagille syndrome.
  • By distribution channel, the market is segmented into hospital pharmacies, retail pharmacies, and online pharmacies. Out of which, hospital pharmacies is expected to dominate the market over the forecast period, and this is attributed to the increasing patient pool of Alagille syndrome.
  • Among all the segmentation, the drug segment is expected to dominate the market over the forecast period, and this is explained by the rising preference of pharmaceutical raw materials for the creation of new medications to treat Alagille syndrome.  

Alagille Syndrome Treatment Market Report Coverage

Report Coverage Details
Base Year: 2022 Market Size in 2023: US$ 88.9 Mn
Historical Data for: 2018 to 2021 Forecast Period: 2023 to 2030
Forecast Period 2023 to 2030 CAGR: 6.6% 2030 Value Projection: US$ 138.7 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Drug: Ursodeoxycholic Acid, Cholestyramine, Rifampicin, Late Stage Pipeline Drugs, Others
  • By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies 
Companies covered:

Teva Pharmaceutical Industries Ltd., AbbVie, Inc., Glenmark Pharmaceuticals Limited, Par Pharmaceuticals, Inc., Mylan Pharmaceuticals, Inc., Sanofi S.A., Mylan N.V., Novartis International AG, Akorn, Inc., Albireo Pharma, Inc., Mirum Pharmaceuticals, Ipsen Pharma, and  CANbridge Pharmaceuticals, Inc.

Growth Drivers:
  • Increasing interest by researchers and key market palyers
Restraints & Challenges:
  • Less awareness about alagille syndrome

Global Alagille Syndrome Treatment Market - Cross Sectional Analysis:

Key players are making new drugs for the treatment of Alagille syndrome with advanced technology, which is expected to boost the demand for the alagille syndrome treatment market in the North America region. Alagille syndrome is a rare genetic disorder that affects the liver and other organs, causing various complications. The development of new drugs using advanced technology signifies a significant breakthrough in the treatment of this complex condition, offering hope for improved outcomes and a better quality of life for patients in North America. These new drugs have the potential to target specific genetic mutations associated with Alagille syndrome, providing more personalized and effective treatment options. Additionally, the advancements in technology have also led to improved diagnostic tools, allowing for earlier detection and intervention of Alagille syndrome in North America.

Global Alagille Syndrome Treatment Market: Key Developments

  • On June 2, 2023, CANbridge Pharmaceuticals, Inc., a global biopharmaceutical company, announced that the Chinese National Medical Products Administration (NMPA) has approved CAN108 (Maralixibat Chloride Oral Solution/LIVMARLI) to be marketed for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) 1 year of age and older.

Global Alagille Syndrome Treatment Market: Key Trends

  • Approval and launch of new drugs for the treatment: The launch of drug in more than one region for the treatment of Alagille syndrome is expected to drive the growth of the global alagille syndrome treatment market over the forecast period. For instance, in December 2022, Mirum Pharmaceuticals, Inc., a biopharmaceutical company, announced that the European Commission has granted marketing authorization for LIVMARLI (maralixibat) oral solution for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) two months of age and older. The approval follows a positive opinion granted by the European Committee for Medicinal Products for Human Use (CHMP) in September 2022. LIVMARLI is the first and only approved treatment in both the European Union and the U.S. to treat this rare liver disease affecting one out of 30,000 people globally.

Global Alagille Syndrome Treatment Market: Restraint

  • Less awareness about Alagille syndrome: There is less awareness about Alagille syndrome, and because of its rarity, most people ignore the starting symptoms of this syndrome. This lack of awareness often leads to delayed diagnosis and treatment, which can have serious consequences for individuals with Alagille syndrome. It is crucial to raise awareness about this condition and educate the public on recognizing its early symptoms to ensure timely intervention and improved outcomes for affected individuals. By increasing awareness about Alagille syndrome, healthcare professionals can be better equipped to identify and diagnose the condition in its early stages. Additionally, early intervention can help prevent complications and provide appropriate support for individuals with Alagille syndrome and their families. The key players are focusing on developing advanced products with safety and cost effectiveness, which is expected to drive the market growth over the forecast period.

Global Alagille Syndrome Treatment Market - Key Players

The major players operating in the global alagille syndrome treatment market include Teva Pharmaceutical Industries Ltd., AbbVie, Inc., Glenmark Pharmaceuticals Limited, Par Pharmaceuticals, Inc., Mylan Pharmaceuticals, Inc., Sanofi S.A., Mylan N.V., Novartis International AG, Akorn, Inc., Albireo Pharma, Inc., Mirum Pharmaceuticals, Ipsen Pharma, and CANbridge Pharmaceuticals, Inc.

Frequently Asked Questions

The global alagille syndrome treatment market is estimated to be valued at US$ 88.9 Million in 2023 and is expected to exhibit a CAGR of 6.6% between 2023 and 2030.

Increasing interest by researchers and key market palyers is expected to drive the market growth.

Ursodeoxycholic acid is the leading drug segment in the market.

Less awareness about alagille syndrome is expected to hinder the market growth over the forecast period.

The major players operating in the market are Teva Pharmaceutical Industries Ltd., AbbVie, Inc., Glenmark Pharmaceuticals Limited, Par Pharmaceuticals, Inc., Mylan Pharmaceuticals, Inc., Sanofi S.A., Mylan N.V., Novartis International AG, Akorn, Inc., Albireo Pharma, Inc., Mirum Pharmaceuticals, Ipsen Pharma, and CANbridge Pharmaceuticals, Inc.

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