Bone Glue Market Analysis & Forecast: 2025-2032

Bone Glue Market Size and Trends – 2025-2032

The Global Bone Glue Market is estimated to be valued at USD 3.08 Bn in 2025 and is expected to reach USD 4.60 Bn by 2032, exhibiting a compound annual growth rate (CAGR) of 5.9% from 2025 to 2032.

Key Takeaways of the Bone Glue Market:

• Based on type, the natural bone glue segment is expected to contribute the highest share of the market with 43.6% in 2025
• Based on application, the orthopedic surgery segment is expected to contribute the highest share of the market with 32.6% in 2025
• Based on end user, the hospitals segment is projected to contribute the highest share of the market with 44.0% in 2025
• North America is expected to top the global market with 38.8% share, followed by Asia Pacific with 26.8% share in 2025

Market Overview:

The rising geriatric population who are prone to bone-related illnesses like arthritis is prompting the increasing adoption of bone glue products for joint reconstruction and other procedures. Additionally, growing awareness about the benefits of bone glue such as lesser pain, quicker recovery time, and higher success rate of fusion is further fueling the market growth. However, the high costs associated with bone glue products and availability of alternative treatment methods may hamper the market growth to some extent during the forecast years.

Segmental Insights

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Type Insights - The inherent advantages of natural materials will drive the demand for natural bone glue

In terms of type, the natural bone glue segment is expected to contribute the highest share of the market with 43.6% in 2025 owing to its inherent biological compatibility and similarity to the natural bone microenvironment. Being derived from natural animal or human bone tissues, natural bone glue meshes well with the recipient site and induces less inflammatory or immune responses compared to synthetic alternatives. Its protein-based composition allows natural bone glue to degrade gradually and be replaced by the patient's own newly formed bone, eliciting a natural healing process. Additionally, natural bone glue stimulates cell proliferation and new blood vessel formation at the repair site. These unique properties position natural bone glue as the most suitable bone adhesive for complex orthopedic repairs and reconstructive procedures.

Application Insights - Robust efficacy and versatility propels orthopedic surgery as the dominant application

In terms of application, the orthopedic surgery segment is expected to contribute the highest share of the market with 32.6% in 2025 owing to the extensive scope of orthopedic trauma and reconstructive procedures that require bone-bonding solutions. A diverse range of orthopedic applications including fracture fixation, spinal fusion, joint reconstruction, and bone grafting rely upon the fast-acting hemostatic and osteoconductive qualities of bone glue. Compared to alternatives such as screws and plates, bone glue provides stronger, less rigid fixation while eliminating hardware-related complications. Its ease of application to irregular bone surfaces via syringe further increases convenience. Above all, bone glue is highly effective in enhancing fusion rates and surgical outcomes in complex orthopedic surgeries. These factors have made bone glue ubiquitous in orthopedic operating rooms worldwide.

End User Insights - Need for safety and efficacy drives preference for hospitals

In terms of end user, the hospitals segment is expected to contribute the highest share of the market with 44% in 2025 as they provide state-of-the-art infrastructure, quality care, and specialized clinical expertise for complex bone repair procedures that require precision application of bone glue. Relative to other healthcare settings, hospitals offer patients access to experienced surgeons, advanced medical technologies, strict regulatory guidelines, and round-the-clock monitoring in case of complications, all of which guarantee consistency and high standards in surgical outcomes. Moreover, the bulk purchasing agreements between hospitals and manufacturers translate to better pricing and formularies listing bone glue as a preferred method for osteosynthesis. These factors account for the overwhelming preference for bone glue procedures to be performed in the sterile, well-equipped setting of hospitals rather than alternatives such as clinics or ambulatory centers.

Regional Insights

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North America Bone Glue Market Trends

In 2025, North America's dominance in the bone glue market, with a 38.8% share, can be attributed to the strong presence of leading medical device companies, the increasing prevalence of orthopedic diseases and sports injuries, and the growing adoption of advanced ortho biologics in trauma and spinal surgeries. Key players like Smith & Nephew and Stryker have established their positions in the region through continuous innovations.

Asia Pacific Bone Glue Market Trends

The Asia Pacific region exhibits the fastest growth in demand for bone glue with a share of 26.8% in 2025 owing to the increasing healthcare expenditures, rising medical tourism, burgeoning geriatric population, and growing awareness about newer technologies. China and India are emerging as lucrative markets due to the improving economic conditions and expanding customer base.

Bone Glue Market Outlook for Key Countries

United States Bone Glue Market Trends

The U.S. is projected to remain the fastest-growing market for surgical glues in the coming years, driven by an increase in surgical procedures and road accidents necessitating surgical interventions. According to data published by the United States Bureau of Labor Statistics in January 2022, private industry employers reported 2.6 million injury and illness cases. The report also highlighted a 6.8% rise in injury cases, reaching 2.2 million in 2021, underscoring the growing demand for advanced surgical solutions.

Canada Bone Glue Market Trends

Canada drives the surgical glue market due to its advanced healthcare infrastructure, increasing number of surgical procedures, and rising incidence of injury-related hospitalizations. According to data published by the Government of Canada in July 2021, there were 225,208 injury-related hospitalizations (excluding complications from medical and surgical care. The rising number of injuries and emergency cases in the country is anticipated to drive the demand for surgical glue in various surgical procedures.

Japan Bone Glue Market Trends

Japan continues to lead in the usage of sophisticated technologies and adoption of minimally invasive procedures which is expected to drives the bone glue market. Key players such as Kuros Biosciences have established strong footholds. In December 2023, Fujitsu Limited and iSurgery Co. Ltd., in collaboration with Jikei University School of Medicine, launched a bone health promotion project in Japan, running through March 2025.

Sweden Bone Glue Market Trends

Sweden drives the bone glue market through its strong emphasis on innovation, advanced research capabilities, and collaboration between academic institutions and industry players. Researchers at the KTH Royal Institute of Technology in Stockholm, Sweden, developed an adhesive glue utilizing thiol-ene coupling (TEC) technology. This innovative adhesive employs a fundamental bonding method and maintains consistent hardening and setting, even when exposed to oxygen and water.

Market Players, Key Devlopment, and Competitive Intelligence

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Key Developments:

• On December 11, 2024, RevBio, Inc., a clinical stage medical device company, announced the USFDA approval to expand its clinical trial for the immediate fixation of cranial flaps using TETRANITE, its bone adhesive biomaterial. The company also secured reimbursement coverage from the Centers for Medicare and Medicaid (CMS) for TETRANITE as a replacement for metal plates and screws.
• In October 2023, RevBio, Inc., a clinical stage medical device company, announced that it had been awarded a grant of up to US$ 3.4 million over three years from the National Institute on Aging (NIA), a division of the National Institutes of Health (NIH), under its Commercialization Readiness Program. The grant will support the completion of late-stage product development activities and the execution of a clinical trial to evaluate the product's safety and efficacy compared to the current standard of care.
• In December 2021, icotec ag, a manufacturer of Carbon/PEEK implants, partnered with G-21, a company specializing in medical and pharmaceutical products, to distribute G-21’s bone cements alongside icotec's VADER Pedicle Screw System in the U.S. The VADER Pedicle System is designed to restore spinal column integrity in patients with advanced-stage thoracic or lumbar spine tumors who have a limited life expectancy that precludes achieving fusion prior to oncological treatment.
• In November 2021, a study published in Frontiers in Bioengineering and Biotechnology, a multidisciplinary journal, explored the use of a biomimetic bioadhesive for gluing living bone, from initial incision to final healing. The study demonstrated that the OsStic adhesive integrates seamlessly with local bone biology in a murine bone core model, showing no signs of inflammation or adverse tissue effects.

Top Strategies Followed by Global Bone Glue Market Players

• Established Players: Leading companies in the bone glue market prioritize extensive research and development to innovate high-performance products
  • For instance, companies like Stryker and Zimmer Biomet have significantly increased their R&D budgets, focusing on developing next-generation adhesives that enhance surgical outcomes and reduce recovery times. This commitment to innovation is crucial for maintaining competitive advantage in a rapidly evolving market
• Mid-Level Players: Cost-Effective Solutions: Mid-level players focus on delivering quality, budget-friendly products targeting price-sensitive consumers
  • For instance, companies like Medtronic have introduced cost-effective bone glue options that maintain quality while appealing to hospitals looking to reduce expenses
• Small-Scale Players: Small players often target niche markets with unique features or innovative products. By focusing on specific applications or developing specialized bone adhesives, they cater to unmet needs within the broader market. The use of cutting-edge technologies, such as 3D printing and nanotechnology, enables small-scale companies to remain competitive. These technologies allow for the development of customized and high-performance bone adhesives.

Emerging Startups - Bone Glue Industry Ecosystem

• Innovative Technologies: Startups like Pixee Medical are developing advanced technologies such as augmented reality solutions for orthopedic surgery. Their innovations aim to enhance surgical precision and improve patient outcomes. The introduction of these technologies has the potential to significantly influence market dynamics by setting new standards for surgical procedures and patient care.
• Sustainable Solutions: Companies such as Anthropic are developing bone glues using sustainable biopolymers and natural compounds, while NovoBone focuses on creating bone graft substitutes from seaweed-based hydrogels. These innovative startups aim to reduce the industry's ecological footprint by offering eco-friendly alternatives to synthetic materials.

Market Report Scope

Market Dynamics

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Bone Glue Market Growth Factors - Rising Incidence of Osteoporosis and Bone-related Disorders

The prevalence of osteoporosis and other bone disorders has been rising each year owing to aging population and lifestyle changes. Some of the key drivers have been increased life expectancy, sedentary routines, unhealthy diets, and lack of exercise. For instance, on January 18, 2022, a report published by Taylor & Francis Online, a peer-reviewed journal publisher, highlighted that osteoporosis is responsible for over 8.9 million fractures annually, equating to an osteoporotic fracture occurring every 3 seconds worldwide. The report also estimated that osteoporosis affects 200 million women globally, with one-tenth of women aged 60, one-fifth aged 70, two-fifths aged 80, and two-thirds aged 90 diagnosed with the condition.

Bone Glue Market Challenge - High cost of advanced bone glue products

One of the major challenges currently being faced by the global bone glue market is the high cost of advanced bone glue products. Developing innovative bone glue solutions that are effective in facilitating bone healing requires extensive research and clinical testing. This results in heavy R&D investments for market players. Further, stringent regulatory approvals for new product launches adds to overall costs. The price sensitivity in developing regions therefore restricts the adoption of premium bone glue products in such areas. Market players need to focus on gradual price reductions through economies of scale and improved manufacturing efficiencies. Partnerships with local medical device players could also help in customizing and positioning affordable product options. However, affordability should not compromise on product efficacy and safety standards.

Bone Glue Market Opportunities - Development of Biocompatible and Bioresorbable Materials

The global bone glue market has significant opportunities through the development of novel biocompatible and bioresorbable materials. Currently, majority of bone glue products use synthetic polymers that are not absorbed by the body and require a second surgery for removal. Innovating materials that get absorbed naturally post healing process could offer several advantages. It eliminates complications associated with permanent implants and reduces pain and discomfort for patients. From a business perspective, developing resorbable solutions open lucrative opportunities in pediatric and trauma fixation applications. Key players should focus R&D investments into characterization of naturally occurring molecules and polymers with adhesive and healing properties.

Analyst Opinion (Expert Opinion)

• The bone glue market faces strong growth prospects over the coming years owing to rising orthopedic surgeries globally. Increased prevalence of osteoporosis, accidental injuries, and age-related bone disorders are anticipated to drive the demand for bone glue in trauma and reconstructive procedures. Furthermore, bone glue offers surgeons convenience as it eliminates the need for plates and screws in certain bone fixation applications. Its ease of application and ability to set in a few minutes within the body are positive attributes compared to alternative synthetic fixation materials.
• Stringent regulatory guidelines for bringing new medical adhesives to market may restrain the pace of innovation. Long review periods and expensive clinical trials pose barriers for new entrants. Additionally, existing cements have well-established routines among orthopedists, so switching costs are high for converting to newer versions. The North America region currently dominates the bone glue landscape due to favorable reimbursement policies and a large base of orthopedic specialists. Still, Asia Pacific is likely to witness stronger growth over the coming years. Rising medical tourism along with growing orthopedic expertise could boost the uptake of advanced fixation materials like bone glue in countries like China, India, and Japan.

Market Segmentation

•  Type Insights (Revenue, USD Bn, 2020 - 2032)
• • Natural Bone Glue
  • Synthetic Bone Glue
  • Modified Bone Glue
•  Application Insights (Revenue, USD Bn, 2020 - 2032)
• • Orthopedic Surgery
  • Trauma Surgery
  • Dental Surgery
  • Spine Surgery
•  End User Insights (Revenue, USD Bn, 2020 - 2032)
• • Hospitals
  • Clinics
  • Ambulatory Surgical Centers
  • Others
•  Formulation Insights (Revenue, USD Bn, 2020 - 2032)
• • Liquid
  • Gel
  • Powder
• Regional Insights (Revenue, USD Bn, 2020 - 2032)
• • North America
    • U.S.
    • Canada
  • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Rest of Latin America
  • Europe
    • Germany
    • U.K.
    • Spain
    • France
    • Italy
    • Russia
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • Australia
    • South Korea
    • ASEAN
    • Rest of Asia Pacific
  • Middle East
    • GCC Countries
    • Israel
    • Rest of Middle East
  • Africa
    • South Africa
    • North Africa
    • Central Africa
• Key Players Insights
  • Medtronic
  • Johnson & Johnson
  • Stryker
  • Braun Melsungen AG
  • Zimmer Biomet
  • Smith & Nephew
  • Baxter International
  • Integra LifeSciences
  • CryoLife
  • Heraeus Medical
  • DJO Global
  • Aesculap
  • Arthrex
  • Exactech
  • Cardinal Health