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  • Published On : Aug 2022
  • Code : CMI242
  • Industry : Medical Devices
  • Pages : 196
  • Formats :

Osteoporosis is a common cause for bone fractures and its prevalence gradually increases with age. For instance, in August 2021, according to the reports published in BMC Pediatrics, an open access journal publishing peer-reviewed research articles, bone fractures account for 25 % of accidents and injuries among all children and adolescents globally, with an ADHD, Attention-deficit/hyperactivity disorder, prevalence of 5 % among children and adolescents.

As bone health significantly deteriorates with age, this would lead to a large number of accidents and resultant fractures. For instance, on January 18, 2022, a report was published by Tylor & Francis Online, peer-reviewed journal articles publisher, stated that osteoporosis causes more than 8.9 million fractures annually, resulting in an osteoporotic fracture every 3 seconds globally. It is also estimated that osteoporosis affects 200 million women worldwide. One-tenth of women aged 60, one-fifth of women aged 70, two-fifths of women aged 80 and, actually two-thirds of women aged 90 carry this diagnosis globally.

Global bone glue market size was valued at US$ 2,332.0 Million in 2022 and is expected to witness a CAGR of 5.9% over the forecast period (2022 – 2030).

Figure 1. Global Bone Glue Market Share (%), by Product Type, 2022

Bone Glue  | Coherent Market Insights

Increasing number of bone disorders and rising number of arthroplasty are expected to drive growth of the global bone glue market

Increasing prevalence of bone disorders and rising geriatric population are major factors that are driving growth of the bone glue market. For instance, according to the report of Arthritis Foundation of 2018, osteoarthritis (OA) is the most common bone and joint disorder in the U.S., wherein around 30.8 million U.S. adults suffer from osteoarthritis. Furthermore, as per the same source, osteoarthritis is the most common cause of disability in the U.S. adults aged above 60 and older.

Increasing number of arthroplasty procedures and consequent rise in demand for newer bone glues across various countries in North America and Europe is expected to fuel growth of the bone glue market. For instance, according to the Journal of Bone and Joint Surgery published data in September 2018, primary total hip arthroplasty (THA) is projected to grow 71%, to 635,000 procedures by 2030 and primary total knee arthroplasty (TKA) is projected to grow 85%, to 1.26 million procedures by 2030 in US.

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Bone Glue Market Report Coverage

Report Coverage Details
Base Year: 2021 Market Size in 2022: US$ 2,332.0  Mn
Historical Data for: 2017 to 2030 Forecast Period: 2022 to 2030
Forecast Period 2022 to 2030 CAGR: 5.9% 2030 Value Projection: US$ 3,687.8 Mn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC Countries, Israel, and Rest of Middle East
  • Africa: South Africa, North Africa, and Central Africa
Segments covered:
  • By Product Type: Synthetic Bone Glue, Natural Bone Glue, By Therapeutic Application:, Osteoporosis, Sports Injuries, Spinal Injuries, Traumatic Bone Fracture, Bone Tumor
  • By End User: Hospitals, Clinics, Specialized Orthopedic Clinics, Ambulatory Surgical Centers
Companies covered:

Cryolife, Luna Innovations Incorporated., St. Jude Medical, Inc. (Abbott Laboratories), Johnson and Johnson, Cohera Medical Inc, Tissuemed Ltd., Integra Lifesciences Corporation, Baxter International Inc., B.Braun Melsungen AG, DENTSPLY SIRONA Inc., Chemence Medical Inc., LaunchPad Medical, and C.R. Bard Inc.

Growth Drivers:
  • Increasing number of bone disorders and rising number of arthroplasty
  • Increasing research and development activities regarding bone glue products
Restraints & Challenges:
  • Inhibition in the production of natural glue obtained from animals

Figure 2. Global Bone Glue Market Share (%), by Region, 2022

Bone Glue  | Coherent Market Insights

Increasing research and development activities concerning bone glue products attributing to the highest share of North America market in the global bone glue market.

On the basis of region, the global bone glue market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America holds dominant position in the global bone glue market, owing to increasing research and development activities regarding bone glue products. For instance, in April 2018, the KTH Royal Institute of Technology in Stockholm, a public research university, Sweden created an adhesive glue with thiol-ene coupling (TEC) technology that uses the fundamental bonding method and hardens and sets consistently even when exposed to oxygen and water. The three-layered adhesive technique resembles a sandwich of biocompatible glue and fibre. An ideal remedy for painful bone damage and acute bone fractures can be offered by this efficient adhesive.

Global Bone Glue Market– Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization had declared it a public health emergency on January 30, 2020.

The sudden outbreak of COVID-19 has bought the world to a standstill. The whole world is fighting this pandemic with increased burden on hospitals and healthcare professionals. For instance, in January 2021, according to the reports published in Revista Española de Cirugía Ortopédica y Traumatología, (Journal of Orthopaedic Surgery and Traumatology) is the official publication of the Spanish Society of Orthopaedic Surgery and Traumatology, published a  report on Thirty-day mortality in patients with a proximal femur fracture during the COVID-19 pandemic in Biscay (Basque Country), which stated that SARS CoV-2 infection in patients with a proximal femur fracture was seen to result in higher rates of early mortality, with COVID-19-related pneumonia being the leading direct cause of mortality.

Global Bone Glue Market: Key Developments

  • In November 2021, a report was published in Frontiers in Bioengineering and Biotechnology, A multidisciplinary journal, on gluing living bone using a biomimetic bioadhesive: from initial cut to final healing, which reported that the OsStic adhesive harmonizes with the local bone biology in the murine bone core model with no signs of inflammation or adverse tissue effects throughout the study. The sticky layer is replaced by bone multicellular units throughout the healing of the sliced bone core surfaces, and by 42 days, the cortical and cancellous compartments of the bone have recovered up to 50% and 70% of their original quality and quantity.
  • For instance, in December 2021, icotec ag, a medical device manufacturer of Carbon/PEEK implants company, strategically corporates with G-21, medical and pharmaceutical sector company, to distribute their bone cements in conjunction with icotec's VADER Pedicle Screw System in the U.S. The VADER Pedicle System is intended to restore the integrity of the spinal column even in the absence of fusion in patients with advanced stage tumors involving the thoracic or lumbar spine in whom life expectance, prior to oncological treatment, is of insufficient duration to permit achievement of fusion.
  • For instance, in December 2020, Smith & Nephew, a multinational medical equipment manufacturing company, started a field action to remove one batch of Versabond AB 40 Grams Formulation 2 due to possible exposure to heat and humidity, Smith & Nephew started a field action to remove one batch of Versabond AB 40 Grams Formulation. When mixed, the impacted lot was said to have an unusually sand-like, flaky, or gritty consistency. VERSABOND is a medium viscosity bone cement which can be used for hip, knee, and shoulder implant fixation with superior handling and mechanical properties.

Global Bone Glue Market Restraints

However, stringent regulations in the U.S. such as institutions and universities that use animals for research purpose should be licensed and or registered with the U.S. department of agriculture and facilities and regulated animals must be inspected yearly by the USDA’s animal and plant health inspection service are negatively affecting the market growth due to inhibition in the production of natural glue obtained from animals.

Non-animal substitutes i.e. synthetic glue is relatively more expensive and can also lead to compatibility issues with bones. Difficulties such as irritation caused by the cement to the surrounding skin over prolong application, breakdown of the cement causes artificial joint to come loose, and breakage of cement in bits that are associated with cemented arthroplasty are main concerns.

Key Players

Key players operating in the global bone glue market include Cryolife, Luna Innovations Incorporated., Johnson and Johnson, Cohera Medical Inc, Tissuemed Ltd., Integra Lifesciences Corporation, Baxter International Inc., B.Braun Melsungen AG, DENTSPLY SIRONA Inc., Chemence Medical Inc., LaunchPad Medical, and C.R. Bard Inc.

Bone glues are a collagen obtained from an animal base that mainly includes skin and bones. Bone glues are derivative of fish’s dehydrated bladder and dense bone. The production process of bone glue is complicated, which involves obtaining animal bones from various abattoirs, meat packaging companies, and tanneries. The bones are cleaned, washed and are set under pressure to boil to demineralize it and then collagen is extracted and dried. The most used commercial area apart from healthcare industry is in manuscript publishing, carpentry, and gun powder production applications. The bone glue market is expected to gain steady traction in the near future, as it finds application in various industries.

Market Dynamics

Increasing number of osteoporosis procedures is expected to drive the bone glue market growth during the forecast period. For instance, on January 12, 2022, according to the report published in Arthroplasty Today, an official journal of the American Association of Hip and Knee Surgeons, published an annual report which reported 2,244,587 primary revision hip and knee arthroplasties between 2012 and 2020 in US. Female patients represented 58.5% of all procedures while male patients represented 38.6% of cases. THA (Total hip arthroplasty) patients were on average 66.1 years old, whereas TKA (Total Knee Arthroplasty) patients were on average 67 years old.

Bone density decreases with age, often leading to bone disorders among people over 60 years of age. According to the WHO, bones become especially fragile in elderly women. Approximately 1 in 4 women i.e. around 24% of women aged 50 or older suffer from falls and accidents each year globally. In many instances, most of the falls lead to fracture, out of which 35-40% of bone fractures are healed or joined with the use of bone glue globally.

Key features of the study:                                         

  • This report provides an in-depth analysis of the global bone glue market, market size (US$ Mn), and compound annual growth rate (CAGR (%)) for the forecast period: 2022 – 2030, considering 2021 as the base year
  • It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by leading players
  • It profiles key players in the global bone glue market based on the following parameters – company overview, financial performance, product portfolio, geographical presence, distribution strategies, key developments, and strategies
  • Key players covered as a part of this study include, Cryolife, Luna Innovations Incorporated, Johnson and Johnson, Cohera Medical Inc, Tissuemed Ltd., Integra Lifesciences Corporation, Baxter International Inc., B.Braun Melsungen AG, DENTSPLY SIRONA Inc., Chemence Medical Inc., LaunchPad Medical, and C.R. Bard Inc.
  • Insights from this report would allow marketers and management authorities of companies to make informed decision with respect to their future product launches, governmental initiatives, technological up-gradation, market expansion, and marketing tactics
  • The global bone glue market report caters to various stakeholders in this industry, including investors, product manufacturers, distributors, suppliers, research and consulting firms, new entrants, and financial analysts
  • Stakeholders would have ease in decision making through various strategy matrices used in analyzing the global bone glue market.

Detailed Segmentation:

  • Global Bone Glue Market, By Product type:
    • Synthetic Bone Glue
    • Natural Bone Glue
  • Global Bone Glue Market, By Therapeutic Application:
    • Osteoporosis
    • Sports Injuries
    • Spinal Injuries
    • Traumatic Bone Fracture
    • Bone Tumor
  •  Global Bone Glue Market, By End User:
    • Hospitals
    • Clinics
    • Specialized Orthopedic Clinics
    • Ambulatory Surgical Centers
  •  Global Bone Glue Market, By Region:
    • North America
      • By Country
        • U.S.
        • Canada
    • Europe
      • By Country
        • U.K.
        • Germany
        • Italy
        • Spain
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • By Country
        • Australia
        • India
        • China
        • Japan
        • ASEAN
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • By Country
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Middle East
      • By Country
        • GCC
        • Israel
        • Rest of Middle East
    • Africa
      • By Country
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Cryolife*
      • Company Highlights
      • Product Portfolio
      • Financial Performance
      • Recent Highlights
      • Market Strategies
    • Luna Innovations Incorporated.
    • Jude Medical, Inc. (Abbott Laboratories)
    • Johnson and Johnson
    • Cohera Medical Inc
    • Tissuemed Ltd.
    • Integra Lifesciences Corporation
    • Baxter International Inc.
    • Braun Melsungen AG
    • DENTSPLY SIRONA Inc.
    • Chemence Medical Inc.
    • LaunchPad Medical
    • R. Bard Inc.

 “*” marked represents similar segmentation in other categories in the respective section.

Frequently Asked Questions

The global bone glue market is estimated to surpass US$ 3,687.8 Million by 2030
Major players operating in the market include Cryolife, Luna Innovations Incorporated., Johnson and Johnson, Cohera Medical Inc, Tissuemed Ltd., Integra Lifesciences Corporation, Baxter International Inc., B.Braun Melsungen AG, DENTSPLY SIRONA Inc., Chemence Medical Inc., LaunchPad Medical, and C.R. Bard Inc.
Among product type, Synthetic Bone Glue segment generated significant revenue in 2022, owing to increasing bone disorders and rising number of arthroplasty.
Increasing number of bone disorders and rising number of arthroplasty are expected to drive growth of the market.
The market is estimated to exhibit a CAGR of 5.9% over the forecast period.
Among regions, North America is expected to witness significant growth over the forecast period, owing to increasing research and development activities concerning bone glue products.

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