Bone Glue: Cementing the Path to Effective Bone Healing
Osteoporosis is a common cause for bone fractures and its prevalence gradually increases with age. For instance, the prevalence ratio of osteoporosis increase from 5% at 50 years to 50% at 85 years among women. According to the National Osteoporosis Foundation, there were 7-8 million females aged over 50 years suffering from osteoporosis and 21.8 million suffering from osteopenia in the U.S., in 2002. It further states that the number of bone fractures will increase by 2 to 4 times by 2020 and 41 million women will suffering from osteoporosis or osteopenia. This is mainly attributed to significant rise in the aging population. In 2002, 12–17% of the population in Europe were aged over 65, which is expected to increase to 20–25% by 2025. As bone health significantly deteriorates with age, this would lead to a large number of falls and resultant fractures. Statistics released by the National Osteoporosis Foundation further revealed that 1.3 million hip fractures were report worldwide in 1990, which is expected to increase by 4.5 million by 2050. This inadvertently will boost growth of the bone glue market. According to Medanta Medicity—a major multi-specialty hospital based in India—Indians are found to have 15% lower bone density which puts Indians at a greater risk of broken bones compared to Caucasians.
The global bone glue market was valued at US$ 1,648.3 million in 2015 and is expected to witness a CAGR of 6.3% during the forecast period (2016 – 2024).
Figure 1. Global Bone Glue Market Share, By Product Type (%)
Naturally produced bone glue from animals hits the bone glue market
The growing prevalence of bone disorders and ageing population are the important aspects for the significant growth in bone glue market in Europe. Growing number of arthroplasty procedures and the consequent rise in demand for newer bone glues across various countries in Europe would further fuel growth of bone glue market in the region. However, stringent regulations in US such as, institutions and universities who use animals for research purpose should be licensed and or registered with the U.S. Department of Agriculture and facilities, regulated animals must be inspected yearly by USDA’s Animal and Plant Health Inspection Service, has hit the bone glue market by inhibiting the production of natural glue obtained from animals. Non-animal substitutes i.e. synthetic glue are relatively more expensive and can also lead to compatibility issues. Difficulties such as the irritation caused by the cement to the surrounding skin, over prolong application, breakdown of the cement can cause the artificial joint to come loose, breakage of cement in bits are associated with cemented arthroplasty is the one of the main concerns which hamper the growth of the bone glue market.
Bone cement implantation syndrome is most prominent in patients undergoing hip fracture treatment
Bone glue is a basic product needed in any minor fractures and also act as beneficial supplements for musculoskeletal tissue suture repair. There are various other options such as bone cement and bone surgery to treat multiple fractures. A study was conducted by various medical institutes and university hospitals in 2014, with a patient pool of around 1,016 patients who underwent cemented hemiarthroplasty at some point in their life. A common symptom called bone cement implantation syndrome was observed in people suffering from hip fractures and the incidence rate was reported to be between 25% and 30%. Severe bone cement implantation syndrome was observed in 5–7% of patients in the study group. Independent preoperative threat issues for occurrence of bone cement implantation syndrome were irregularities in overall health conducted by the universities, i.e. ASA scores, COPD, and medication with diuretics and warfarin. In cemented total hip arthroplasty, fatalities were pegged at 0.11% and the death occurred during the time of cementation. Considering all these factors, companies have developed bone glue products. The increased usage of bone glue in such cases would boost growth of the bone glue market.
Bone glues are a collagen obtained from an animal base that mainly includes skin and bones. Bone glues are derivative of fish’s dehydrated bladder and dense bone. The production process of bone glue is complicated, which involves obtaining animal bones from various abattoirs, meat packaging companies, and tanneries. The bones are cleaned and washed set for under pressure to boil to demineralize it and then collagen is extracted and dried. The most used commercial area apart from healthcare industry is in manuscript publishing, carpentry, and gun powder production applications.
The bone glues market is expected to gain steady traction in the foreseeable future as the product finds application across a wide number of industries. Manufacturers are focused on reducing production costs and increasing profitability by developing multipurpose bone glues.
The growing incidence of bone associated disorders is a key factor fueling growth of the global bone glue market. Approximately 1.5 million bone splintering cases lead to over half a million hospitalizations in the U.S. each year. Hip fractures is one of the prevalent of bone fractures, resulting in over 300 thousand hospitalizations annually. Apart from general bone fracture, procedures related to bone, such as arthroplasty and rising demand for advanced bone glues in North America and Europe are factors projected to fuel growth of the global market over the forecast period. Product portfolio expansion and development of new products that can heal the bone crack, are some of the other factors augmenting growth of the global bone glue market. Complex regulatory process and limited therapeutic applications of wound care products are impeding growth of the global bone glue market.
This report segments the global bone glue market on the basis of product type, therapeutic application, end user, and geography. On the basis of product type, the bone glue market is categorized into synthetic bone glue and natural bone glue. On the basis of therapeutic application, the bone glue market is categorized into arthroplasty, sports injuries, spinal injuries and others. On the basis of end-user, the bone glue market is categorized into hospital, clinics, and specialized orthopedics clinic and ambulatory surgical centers. For comprehensive understanding of market dynamics, the global one glue market is analyzed across key geographical regions namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.
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*Browse 90 market data tables and 35 figures on "Bone Glue Market - Global forecast to 2024”.
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