Epidermolysis bullosa is a group of rare inherited skin disorders that causes the skin to become very fragile. Any trauma or friction to the skin can cause painful blisters. The symptoms of epidermolysis bullosa include skin that blisters easily, blisters on hands and soles of the feet, thickened skin that may be scarred or change color over time, and thickening of the skin and nails.
There are three types of epidermolysis bullosa which includes:
The type reflects where on the body the blistering takes place and which layer of skin is affected.
Global epidermolysis bullosa market is estimated to be valued at US$ 3,429.30 million in 2022 and is expected to exhibit a CAGR of 11.2% over the forecast period (2022-2030)
Figure 1. Global Epidermolysis Bullosa Market Value (US$ Mn), By Region, 2022
Increasing prevalence of epidermolysis bullosa is expected to drive growth of the global epidermolysis bullosa market over the forecast period.
For instance, according to the data published in the Orphanet Journal of Rare Diseases in 2020, the overall prevalence of epidermolysis bullosa in the U.S. is 11.1 per million live births with an incidence of 1 in every 51,000 live births.
Figure 2. Global Epidermolysis Bullosa Market Share (%), By Product Type, 2022
Global Epidermolysis Bullosa Market Drivers
Increasing clinical trials for the treatment of epidermolysis bullosa is expected to propel the market growth over the forecast period.
For instance, on July 25, 2022, InMed Pharmaceuticals, Inc., which is involved in the research, development, manufacturing, and commercialization of rare cannabinoids INM-755 cannabinol cream for epidermolysis bullosa, provided an update that adolescent patients can participate in the clinical trial.
Moreover, on February 22, 2019, Phoenix Tissue Repair, Inc., a biotechnology company focused on developing a disease-modifying treatment for Dystrophic Epidermolysis Bullosa (DEB), announced that the first patient had been dosed in phase 1/2, first-in-human trial of PTR-01, a protein replacement therapy for recessive DEB.
|Base Year:||2021||Market Size in 2022:||US$ 3,429.30 Mn|
|Historical Data for:||2017 to 2020||Forecast Period:||2022 to 2030|
|Forecast Period 2022 to 2030 CAGR:||11.2%||2030 Value Projection:||US$ 8,008.50 Mn|
Amryt Pharma, Abeona Therapeutics, Castle Creek Pharmaceuticals, RegeneRx, Krystal Biotech, RHEACELL GmbH, Holostem Terapie Avanzate, StemRim/Shionogi, and Phoenix Tissue Repair
|Restraints & Challenges:||
Global Epidermolysis Bullosa Market – Impact of Coronavirus (COVID-19) Pandemic
The coronavirus (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19 a pandemic on March 11, 2020. According to the Coronavirus (COVID-19), Weekly Epidemiological Update by the World Health Organization, over 633,263,617 cases of coronavirus disease (COVID-19) were reported till November 15, 2022, across the globe.
The COVID-19 pandemic caused major disruptions to clinical trial execution in the U.S., impacting key stakeholders across the industry. Investigative site capabilities experienced social-distancing protocols, financial losses, and concerns over patient safety. Sponsors, CROs (clinical research organizations), and other organizations that support drug development shifted to remote working environments. According to Lancet, an estimated 80% of non-COVID-19 trials were stopped or interrupted as a result of the COVID-19 pandemic.
Global Epidermolysis Bullosa Market Restraint
The high treatment cost of epidermolysis bullosa is expected to hinder the market growth over the forecast period.
For instance, according to the data published in the National Center for Biotechnology Information on September 8, 2020, the average monthly bandage cost epidermolysis bullosa range from US$ 262 to > US$ 2,000.
Major players operating in the global epidermolysis bullosa market include Amryt Pharma, Abeona Therapeutics, Castle Creek Pharmaceuticals, RegeneRx, Krystal Biotech, RHEACELL GmbH, Holostem Terapie Avanzate, StemRim/Shionogi, and Phoenix Tissue Repair.
Epidermolysis bullosa is a genetic disorder characterized clinically by blister formation from mechanical trauma. There are four main types with additional sub-types identified. There is a spectrum of severity, and within each type, one may be either midely or severely affected. Epidermolysis bullosa range from being a minor inconvenience requiring modification of some activities, to being completely disabling and, in some cases, fatal.
Friction causes blister formation, blisters can form anywhere on the surface of the skin, within the oral cavity and in more severe forms many also involve the external surface of the eyes, as well as the respiratory, gastrointestinal and genitourinary tracts. In some form of the dieases,disfiguring scars and disabling musculoskeletal deformities occur.
The increasing prevalence of epidermolysis bullosa globally, rising research and development activities, and increasing adoption of inorganic growth strategies such as mergers, acquisitions, partnerships, and collaborations by key players operating in the market are the major factors that are expected to drive the growth of the global epidermolysis bullosa market over the forecast period.
For instance, in March 2020, Abeona Therapeutics Inc., a gene and cell development company announced that the first patient treated in a pivotal phase III clinical trial evaluating EB - 101 gene therapy for recessive dystrophic epidermolysis bullosa.
Key features of the study:
“*” marked represents similar segmentation in other categories in the respective section.
Joining thousands of companies around the world committed to making the Excellent Business Solutions.View All Our Clients