Lyophilization/Freeze Drying Equipment Market - Size, Share, Trends, and Forecast to 2026, by Scale of Production (Industry Scale, Pilot Scale, and Lab Scale), by Product Type (Tray-style Freeze Dryers, Manifold Freeze Dryers, and Rotary Freeze Dryers), by Application (Research, Drug Development, Nutraceuticals, and Medical Diagnostics), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa)

  • Published On : Jun 2018 |
  • Pages : 216 Pages |
  • Format : CMI Insight PPT Format CMI Insight PDF Format

Lyophilization/Freeze Drying Equipment Market – Powerful Components of Drug Development & Research

Freeze drying is the removal of ice or other frozen solvents from a material through the process of sublimation and the removal of bound water molecules through the process of desorption. It is an excellent method of preserving a wide variety of heat-sensitive materials such as proteins, microbes, pharmaceuticals, tissues, and plasma. Lyophilization is also used in the biotechnology and biomedical industries to preserve vaccines, blood samples, purified proteins, and other biological material. This process provides an efficient technique for preservation of temperature sensitive and biologic products such as proteins, enzymes, blood plasma, and vaccines.

The global lyophilization/freeze drying equipment market size was valued at US$ 2,116.5 million in 2017, and is expected to exhibit a robust CAGR of 6.5% over the forecast period (2018 – 2026).

Figure 1. Global Lyophilization/Freeze Drying Equipment Market Value (US$ Mn), by Region, 2017

lyophilization freezedrying equipment market

Source: Coherent Market Insights Analysis (2018)

xIncreasing biopharmaceutical production with extensive R&D is expected to drive growth of the market

Increasing number of drug development process and biopharmaceutical research is a major factor augmenting growth of the market as lyophilization is widely used for pharmaceuticals/ biopharmaceuticals to improve stability, thereby achieve adequate shelf life. Lyophilization or freeze-drying is vital process in developing and manufacturing unstable and sensitive pharmaceuticals, as they aid in introducing new pharmaceutical to market. Biopharmaceuticals are produced by genetically modified organisms and are temperature sensitive complex molecules, which require gentle freeze drying with the lyophilisation process to attain adequate shelf life. According to the survey by Martin Christ GmbH, around 60% of the biopharmaceutical products, such as special cancer treatment substances and antibodies, require freeze drying for attaining efficient results in clinical trials. Also, increasing number of global biopharmaceutical companies is expected to boost market growth over the forecast period as these companies are highly dependent on lyophilization due to wide availability of biologics, which include vaccines, blood components, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, biopharmaceutical companies are focused on developing drugs for treatment of diseases such as cancers which has 1,919 medicines in development, 563 medicines for cardiovascular diseases and 1,123 medicines for immunological disorders, which require recombinant proteins for various stages for drug development. Also, according to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested an estimated US$ 58.8 billion in research and development in 2015, which was the majority of all biopharmaceutical R&D spending in the U.S.

Moreover, according to the survey by Future Science Group, 2016, injectable products are majorly selected as formulations for new therapeutics. However, liquid formulations often enhances degradation through hydrolysis. Thus, lyophilization/ freeze-drying is regularly used in pharmaceutical manufacture to reduce water activity and assure product stability.

Increasing funds and high investment for development of drugs to accelerate market growth in Asia Pacific

The lab-scale freeze dryers are used in R&D prior to a scale up, as moving a new product to commercial-scale manufacturing requires careful validation. Demonstrating batch uniformity is an essential part of this critical process. Moreover, freeze-drying has created novel opportunities in the area of oral drug delivery, where the properties of the drugs, excipients and characteristics of the final solid dosage form can be modified by the freeze-drying process. Asia Pacific region is estimated to witness significant growth in the market, owing to increasing number of research laboratories and pharmaceutical companies with increased expenditure on research and development in this region. For instance, according to the National Bureau of Statistics, February 2018, China’s expenditure on research and development increased by 11.6% in 2017 from 10.6% in 2016 reaching to US$ 280 Bn in 2017. According to the International Journal of Sciences, January 2018, China’s biotechnology sector is expected to exceed by 4% of gross domestic product by 2020, and is expected to develop around 10-20 life-science parks for biomedicine with an output surpassing US$ 1.5 billion.

Major players operating in the global lyophilization/freeze drying equipment market include Thermo Fisher Scientific, Inc., Millrock Technology Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry.

Freeze-drying/lyophilization is typically used in the pharmaceutical companies to recover an active pharmaceutical ingredient from an aqueous solution. The main advantage of freeze drying is that the thermo labile components such as hormones, proteins, hormones can be preserved without damaging the molecules, as they are highly sensitive to heat. The freeze drying products offer a variety of applications in the field of research and development, therapeutic production, medical diagnostics, thus proving to be a beneficial tool in the pharma and biotech industries. The method is highly preferred due to good physical and chemical properties, enhancement in shelf-life of biotechnological products, nutraceuticals, and medicinal products.

Market Dynamics

Increasing demand for freeze dryers/ lyophilization in the pharmaceutical and biotechnology industry, owing to the increasing number of vaccines, recombinant and injectable formulations is a major factor augmenting the market growth as these molecules must be freeze-dried for clinical and commercial use. Also, growth in contract manufacturing and contract lyophilization activities by the manufacturers for pharmaceutical industry is expected to propel the growth of market during the forecast period. Furthermore, the launch of innovative systems offering PLC and PAT based control systems, automated loading, and unloading systems are also expected to contribute to the growth of the market. For instance, in 2012, Azbil Telstar, S.L., launched Telstar Lyotris freeze dryer, designed particularly for aseptic, small-scale production of vaccines, antibodies and other advanced drugs and therapies, which require stabilization. Moreover, the dryer has industrial equipment specifications and small-batch flexibility in a compact envelope. However, increased handling and processing time, cost and complexity of the equipment’s, and removal of volatile components from the vacuum are the factors hindering the market growth.

Key features of the study:

  • This report provides in-depth analysis of lyophilization/freeze drying equipment market and provides market size (US$ Million) and Cumulative Annual Growth Rate (CAGR %) for the forecast period (2018 – 2026), considering 2017 as the base year
  • It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrix for this market
  • This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategy adopted by the leading players
  • It profiles leading players in the global lyophilization/freeze drying equipment market based on the following parameters – company overview, financial performance, product portfolio, market presence, distribution strategies, key developments, and strategies, and future plans
  • Key companies covered as a part of this study include Millrock Technology, Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry and Thermo Fisher Scientific, Inc.
  • Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future product launch, technology up-gradation, market expansion, and marketing tactics
  • The global lyophilization/freeze drying equipment market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
  • Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the lyophilization/freeze drying equipment market

Detailed Segmentation:

  • Global Lyophilization/Freeze Drying Equipment Market, By Scale of Operation:
    • Industrial Scale
    • Pilot Scale
    • Lab Scale
  • Global Lyophilization/Freeze Drying Equipment Market, By Product Type:
    • Tray-style Freeze Dryers
    • Manifold Freeze Dryers
    • Rotary Freeze Dryers
  • Global Lyophilization/Freeze Drying Equipment Market, By Application:
    • Research
    • Drug Development
    • Nutraceuticals
    • Medical Diagnostics
  • Global Lyophilization/Freeze Drying Equipment Market, By Geography:
    • North America Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • U.S.
        • Canada
    • Latin America Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • Brazil
        • Mexico
        • Argentina
        • Rest of Latin America
    • Europe Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • Germany
        • U.K.
        • France
        • Italy
        • Spain
        • Russia
        • Rest of Europe
    • Asia Pacific Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • China
        • India
        • Japan
        • Australia
        • South Korea
        • ASEAN
        • Rest of Asia Pacific
    • Middle East Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • GCC
        • Israel
        • Rest of Middle East
    • Africa Lyophilization/Freeze Drying Equipment Market
      • By Scale of Operation:
        • Industrial Scale
        • Pilot Scale
        • Lab Scale
      • By Product Type:
        • Tray-style Freeze Dryers
        • Manifold Freeze Dryers
        • Rotary Freeze Dryers
      • By Application:
        • Research
        • Drug Development
        • Nutraceuticals
        • Medical Diagnostics
      • By Country:
        • South Africa
        • Central Africa
        • North Africa
  • Company Profiles
    • Millrock Technology, Inc.*
      • Company Overview
      • Product Portfolio
      • Financial Performance
      • Key Strategies
      • Recent Developments
    • Thermo Fisher Scientific, Inc.
    • Zirbus Technology GmbH
    • SP Scientific
    • Azbil Telstar, S.L.
    • Biopharma Process Systems Ltd.
    • LTE Scientific Ltd.
    • Martin Christ GmbH
    • GEA Group
    • Cuddon Freeze Dry

*” marked represents similar segmentation in other categories in the respective section.

Table of Contents

  1. Research Objective and Assumption
    • Research Objectives
    • Assumptions
    • Abbreviations
  2. Market Purview
    • Report Description
      • Market Definition and Scope
    • Executive Summary
      • Market Snippet, By Technology
      • Market Snippet, By Disease Indication
      • Market Snippet, By End User
      • Market Snippet, By Region
    • Coherent Opportunity Map (COM)
  3. Market Dynamics, Regulations, and Trends Analysis
    • Market Dynamics
      • Drivers
      • Restraints
      • Market Opportunities
      • Industry Trends
    • Key Highlights
    • Impact Analysis
    • PORTER’s Analysis
  4. Global Lyophilization/Freeze Drying Equipment Market, By Scale of Operation, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017 – 2026
      • Segment Trends
    • Industrial Scale
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Pilot Scale
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Lab Scale
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  5. Global Lyophilization/Freeze Drying Equipment Market, By Product Type, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017 – 2026
      • Segment Trends
    • Tray-style Freeze Dryers
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Manifold Freeze Dryers
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Rotary Freeze Dryers
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  6. Global Lyophilization/Freeze Drying Equipment Market, By Application, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, 2018 and 2026 (%)
      • Y-o-Y Growth Analysis, 2017 – 2026
      • Segment Trends
    • Research
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Drug Development
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Nutraceuticals
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
    • Medical Diagnostics
      • Introduction
      • Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
  7. Global Lyophilization/Freeze Drying Equipment Market, By Region, 2016 – 2026, (US$ Million)
    • Introduction
      • Market Share Analysis, By Region, 2016 and 2026 (%)
      • Y-o-Y Growth Analysis, For Regions, 2017–2026
    • North America
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • U.S.
        • Canada
    • Latin America
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • Brazil
        • Argentina
        • Mexico
        • Rest of Latin America
    • Europe
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • UK
        • Germany
        • Italy
        • France
        • Russia
        • Rest of Europe
    • Asia Pacific
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • China
        • India
        • Japan
        • ASEAN
        • Australia
        • South Korea
        • Rest of Asia Pacific
    • Middle East
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • GCC Countries
        • Israel
        • Rest of Middle East
    • Africa
      • Market Size and Forecast, By Scale of Operation, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Product Type, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Application, 2016 – 2026, (US$ Million)
      • Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
        • Northern Africa
        • Central Africa
        • South Africa
  8. Competitive Landscape
    • Heat Map Analysis
    • Market Share Analysis
    • Company Profiles
      • Millrock Technology, Inc.*
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Thermo Fisher Scientific, Inc.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Zirbus Technology GmbH
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • SP Scientific
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Azbil Telstar, S.L.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Biopharma Process Systems Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • LTE Scientific Ltd.
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Martin Christ GmbH
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • GEA Group
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
      • Cuddon Freeze Dry
        • Company Overview
        • Product Portfolio
        • Financial Overview
        • Key Highlights
        • Market Strategies
    • Analyst Views
  9. Section
    • References
    • Research Methodology
    • About us and Sales Contact

*Browse 48 market data tables and 36 figures on "Lyophilization/Freeze Drying Equipment Market - Global forecast to 2026”.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


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Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.

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Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

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