Metabolism Drugs Market, by Therapy Type (Enzyme Replacement Therapy, Substrate Reduction Therapy, Small Molecule Drugs, and Others), by Application (Glycogen Metabolism Disease, Lipid Metabolism Disease, Amino Acid Metabolism Disease, and Others), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), and by Region (North America, Latin America, Europe, Asia Pacific, the Middle East, and Africa) - Size, Share, Trends, and Forecast till 2026
- Report code : CMI61955 |
- Industry :
Pharmaceutical
- Published On : Jul 2018 |
- Pages : 167 Pages |
- Format :
Metabolism Drugs Market – Insights
Metabolism diseases results from malfunctioning or inadequate function of the body’s original metabolism. Metabolism diseases can also have a genetic origin, as they can be caused by genetic birth defects as well. Metabolic diseases from genetic defects have low incidence and prevalence rate. Metabolism involves breaking down of carbohydrates, proteins, and fats present in the consumed food, to generate energy.
Furthermore, metabolism also involves excretion of nitrogen through urine, and breaking down or converting other substances and chemicals. This metabolism is carried out by certain enzymes and proteins designated for the respective role. However, metabolism functions improperly when enzymes and proteins are either not produced by the body (inherited disorders), or the produced enzymes do not function the way they are mean to.
Metabolic disorders occur due to buildup of proteins, lipids, glycogen, urea, calcium stones, and toxic substances among others. Each of these molecules have certain designated metabolic pathways, and metabolic agents (enzymes, proteins) at work. Inability of these agents to carry out their tasks cause buildup of the molecules in the blood and other places. Few examples of metabolic diseases include gaucher disease, hereditary tyrosinemia, hereditary orotic aciduria, and fabry disease.
Rising prevalence of metabolic diseases is expected to support growth of the metabolism drugs market over the forecast period
Metabolic diseases is a wide category and there are several metabolism disorders caused due to clinically simple defects as well difficult to treat genetic disorders. For instance, obesity is most common type of metabolic disorder and is closely related to metabolic syndrome (a cluster of clinical conditions such as high blood sugar and triglycerides). According to the World Health Organization (WHO), over 650 million people aged 18 years and above were obese in 2016.
Another condition called lysosomal storage disease is a rare disorder, however, a significant number of people are affected with this disease. According to study published in Molecular Genetics and Metabolism Reports in December 2017, lysosomal storage disease has incidence rate of 1 in 4000 to 1 in 13,000 live births. Lysosomal storage disease consists of 60 genetic abnormalities with problematic enzyme function.
Moreover, other rare diseases such as Hunter syndrome (Mucopolysaccaridosis type II (MPS II)), though rare, are life-threatening diseases with no curative treatment available, thus patients are made to rely on available therapies. According to the National Institute of Health 2018 report, Frequency of MPS II is 1 in 100,000 to 1 in 160,000 in males. Increasing incidence of hunter syndrome is expected to boost the metabolism disease drugs market. For instance, in 2014, around 970 patients were enrolled in Hunter Outcome Survey (HOC), which increased to 1195 patients in 2017.
The global metabolism drugs market size was valued at US$ 5,765.3 million in 2017, and is expected to witness a robust CAGR of 6.3% over the forecast period (2018 – 2026).
Figure 1. Global Metabolism Drugs Market Share US$ Mn, by Region, 2018
Source: Coherent Market Insights Analysis (2018)
Newer therapy launches are expected to boost growth of the metabolism drugs market over the forecast period
Manufacturers try to find potential revenue gaining opportunities in each and every disease segment by offering effective therapies. Though the prevalence of rare diseases is low, patients rely on therapies that are made available irrespective of their price. These drugs are difficult to develop, and in turn expensive, still manufacturers create therapies for chronic and difficult-to-cure rare diseases, selling them at higher prices.
Approvals to innovative therapies such as enzyme replacement therapy are expected to influence manufacturers to develop novel therapies in the market. This in turn, is expected to support the metabolism drugs market growth over the forecast period. The U.S. Food and Drug Administration (FDA) approved multiple drugs for gaucher disease. For instance, in 2010, FDA approved Vpriv (velaglucerase alfa), an enzyme replacement therapy (ERT), for type 1 gaucher disease. In 2012, Elelyso (taliglucerase alfa) and in 2014, Cerdelga (eliglustat) was approved by FDA for type 1 gaucher disease.
Moreover, research and development of novel therapies for treatment of rare metabolism diseases such as pompe, and others is expected to positively impact the metabolism drugs market growth. For instance, in October 2017, Amicus Therapeutics received orphan drug designation to ATB200/AT2221 from the U.S. FDA for the treatment of Pompe disease. Moreover, novel gene and RNAi therapies are also under research for treatment of these diseases.
Figure 2. Global Metabolism Drugs Market Share (%), by Application, 2018
Source: Coherent Market Insights Analysis (2018)
However, high cost associated with the treatment and long duration of the treatments is expected to restrain growth of the metabolism drugs market. For instance, according to a research paper published by Harvard School, in 2016, Lumizyme accounted for US$ 100,000 per year for children and US$ 300,000 per year for adult treatments for pompe disease.
Some of the major players operating in the global metabolism drugs market include Merck & Co., Inc., Novartis AG, Amicus Therapeutics, AstraZeneca Plc, Boehringer Ingelheim, Shire Plc, Sanofi Genzyme, BioMarin Pharmaceutical, Inc., Horizon Pharma Plc, and GlaxoSmithKline Plc.
Increasing prevalence of pompe disease is expected to create lucrative opportunities for pharmaceutical manufacturers to develop and commercialize novel treatments for the disease. For instance, according to United Pompe Foundation (UPF), 2017, the estimated incidence of Pompe disease in Holland is 1 in 40,000, in Southern China and Taiwan: 1 in 50,000 births, African-Americans: 1 in 14,000 births and in Caucasian is 1 in 100,000 population. Initiatives from government organizations for drug research and development is supporting growth of the metabolism drugs market.
For instance, in 2016, the scientist from National Institutes of Health researchers collaborated with National Institute of Neurological Disorders and Stroke (NINDS) and the National Center for Advancing Translational Sciences (NCATS) and researchers identified a new molecule that shows promising approach for treatment of the rare gaucher disease. Moreover, in 2014, European Gaucher Alliance launched Gaucher Awareness Day to spread awareness about this rare disease among the population in Europe.
Market Dynamics
Robust pipeline with various therapies such as enzyme replacement therapy, gene therapy, and small molecule drugs is expected to boost the metabolism drugs market over the forecast period. Increased understanding of diseases and rising number of diagnosed patients are expected to increase the number of patients undergoing treatment.
High prevalence of metabolic diseases is expected to support the growth of the metabolism drugs market. For instance, according to the National Institute of Health (NIH) 2018 report, frequency of hunter syndrome is 1 in 100,000 to 1 in 160,000 in males. Enzyme replacement therapy is expected to show significant growth in the metabolism drugs market over the forecast period.
Key features of the study:
- This report provides in-depth analysis of metabolism drugs market and provides market size (US$ Million) and Compound Annual Growth Rate (CAGR %) for the forecast period (2018 – 2026), considering 2017as the base year
- It elucidates potential revenue opportunity across different segments and explains attractive investment proposition matrix for this market
- This study also provides key insights about market drivers, restraints, opportunities, new application launches or approval, regional outlook, and competitive strategy adopted by the leading players
- It profiles leading players in the global metabolism drugs market based on the following parameters – company overview, financial performance, application portfolio, geographical presence, distribution strategies, key developments, and strategies
- Key companies covered as a part of this study include Merck & Co., Inc., Novartis AG, Amicus Therapeutics, AstraZeneca Plc, Boehringer Ingelheim, Shire Plc, Sanofi Genzyme, BioMarin Pharmaceutical, Inc., Horizon Pharma Plc, and GlaxoSmithKline Plc.
- Insights from this report would allow marketers and the management authorities of the companies to make informed decision regarding their future application launches, technology up-gradation, market expansion, and marketing tactics
- The global metabolism drugs market report caters to various stakeholders in this industry including investors, suppliers, application manufacturers, distributors, new entrants, and financial analysts
- Stakeholders would have ease in decision-making through the various strategy matrices used in analyzing the metabolism drugs market
Detailed Segmentation:
- Global Metabolism Drugs Market, By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- Global Metabolism Drugs Market, By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- Global Metabolism Drugs Market, By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- Global Metabolism Drugs Market, By Geography:
- North America
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- U.S.
- Canada
- Europe
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- China
- India
- Japan
- ASEAN
- Australia
- South Korea
- Rest of Asia Pacific
- Latin America
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- Brazil
- Mexico
- Rest of Latin America
- Middle East
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- GCC
- Israel
- Rest of Middle East
- Africa
- By Therapy Type:
- Enzyme Replacement Therapy
- Substrate Reduction Therapy
- Small Molecule Drugs
- Others
- By Application:
- Glycogen Metabolism Disease
- Lipid Metabolism Disease
- Amino Acid Metabolism Disease
- Others
- By Distribution Channel:
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
- By Country:
- Central Africa
- South Africa
- North Africa
- Company Profiles
- Merck & Co., Inc.*
- Company Overview
- Application Portfolio
- Financial Performance
- Key Strategies
- Recent Developments
- Novartis AG
- Amicus Therapeutics
- AstraZeneca Plc
- Boehringer Ingelheim
- Shire Plc
- Sanofi Genzyme
- BioMarin Pharmaceutical, Inc.
- Horizon Pharma Plc
- GlaxoSmithKline Plc
- Merck & Co., Inc.*
“*” marked represents similar segmentation in other categories in the respective section.
Table of Contents
- Research Objective and Assumption
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Therapy Type
- Market Snippet, By Application
- Market Snippet, By Distribution Channel
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Drivers
- Restraints
- Market Opportunities
- Impact Analysis
- PEST Analysis
- PORTER’s Analysis
- Regulatory Scenario
- Global Metabolism Drugs Market, By Therapy Type, 2016 – 2026 (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Enzyme Replacement Therapy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Substrate Reduction Therapy
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Small Molecule Drugs
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Global Metabolism Drugs Market, By Application, 2016 – 2026 (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Glycogen Metabolism Disease
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Lipid Metabolism Disease
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Amino Acid Metabolism Disease
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Others
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Global Metabolism Drugs Market, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2017 – 2026
- Segment Trends
- Hospital Pharmacies
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Retail Pharmacies
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Online Pharmacies
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Mn)
- Global Metabolism Drugs Market, By Regions, 2016 – 2026 (US$ Mn)
- Introduction
- Market Share Analysis, By Region, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, For Regions, 2017–2026
- North America
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- U.S.
- Canada
- Europe
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- China
- India
- Japan
- ASEAN
- Australia
- South Korea
- Rest of APAC
- Latin America
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- Africa
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- Central Africa
- South Africa
- North Africa
- Middle East
- Market Size and Forecast, By Therapy Type, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Application, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Distribution Channel, 2016 – 2026 (US$ Mn)
- Market Size and Forecast, By Country, 2016 – 2026 (US$ Mn)
- GCC
- Israel
- Rest of Middle East
- Competitive Landscape
- Company Profiles
- Merck & Co., Inc.
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Novartis AG
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Amicus Therapeutics
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- AstraZeneca Plc
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Boehringer Ingelheim
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Shire Plc
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Sanofi Genzyme
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- BioMarin Pharmaceutical, Inc.
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Horizon Pharma Plc
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- GlaxoSmithKline Plc
- Company Overview
- Application Portfolio
- Key Developments
- Financial Performance
- Strategies
- Section
- References
- Research Methodology
- About Us and Sales Contact
*Browse 34 market data tables and 43 figures on "Metabolism Drugs Market - Global forecast to 2026”.
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