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  • Published In : Nov 2023
  • Code : CMI5825
  • Pages :160
  • Formats :
      Excel and PDF
  • Industry : Pharmaceutical

Global Wilms Tumor Protein Market experienced substantial growth, and is expected to be valued at US$ 2.92 billion in 2023. It is projected to continue expanding, reaching US$ 4 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 4.6% during the forecast period.

The market focuses on the study, diagnosis, and treatment of Wilms tumor, a kidney cancer primarily affecting children. Wilms tumor protein, also known as WT1, plays a crucial role in regulating cellular processes and serves as a key biomarker for diagnostics and treatment strategies. Diagnostic techniques such as immunohistochemistry and genetic testing enable accurate identification and classification of Wilms tumor based on WT1 abnormalities. The market growth is driven by increasing awareness, advancements in research, and the need for effective management of Wilms tumor.

Global Wilms Tumor Protein Market- Regional Insights

  • North America: North America is expected to be a significant market for the Wilms tumor protein due to advanced healthcare infrastructure, research capabilities, and access to diagnostic and treatment modalities accounting for over 40% of the market share in 2023. The region has well-established pediatric oncology centers and research institutions that contribute to the understanding and management of Wilms tumor.
  • Europe: Europe is second most prominent market for the Wilms tumor protein, with various countries having well-developed healthcare systems and focus on pediatric oncology, accounting for over 38% of the market share in 2023. The region demonstrates advancements in diagnostics and treatment option, including surgical interventions, chemotherapy, and radiation therapy, and thus, contributing to the management of Wilms tumor.
  • Asia Pacific: Asia Pacific region is the third most major market as it presents both opportunities and challenges in the Wilms tumor protein market, accounting for over 22% of the market share in 2023. Some countries in the region such as Japan, South Korea, and Australia have strong healthcare infrastructure and expertise in pediatric oncology. However, access to diagnostics and treatment options may vary across different parts of the region, and thus, affecting the market growth.

Figure 1. Global Wilms Tumor Protein Market Share (%), by Region, 2023


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Analyst Viewpoint:

The Wilms tumor protein (WT1) represents an interesting area for medical research and drug development. As a tumor suppressor implicated in certain cancers like Wilms tumors and leukemias, targeting WT1 selectively could provide new treatment options. However, developing drugs against an intracellular protein poses formulation and delivery challenges. The lack of approved drugs directly targeting WT1 limits our understanding of its full potential as a target.

Nevertheless, the role of WT1 in oncogenesis makes it compelling as researchers increasingly recognize tumors as diseases driven by abnormalities in developmental networks. Some key drivers for WT1 research include recent progress unraveling its complex functions and interactions within gene regulatory networks. Additionally, new insights into WT1 signaling pathways open possibilities for rational drug design.

Global Wilms Tumor Protein Market- Drivers

  • Prevalence of Wilms Tumor: The incidence of Wilms tumor, a type of kidney cancer primarily affecting children, is a major driver of the market. For instance, in January 2020, according to the data published by American Cancer Society, each year, about 500 to 600 new cases of Wilms tumor are diagnosed in the U.S. About 5% of all cancers in children are Wilms tumors. The need for effective diagnostics and treatment options for Wilms tumor boosts demand for Wilms tumor protein-related products and services.
  • Advancements in Diagnostic Technologies: The continuous advancements in diagnostic technologies play a crucial role in the Wilms tumor protein market growth. Improved imaging techniques, genetic testing methods, and molecular diagnostics contribute to accurate detection, classification, and monitoring of Wilms tumor, with the Wilms tumor protein being a key biomarker in these diagnostic approaches. For instance, on February 23, 2023, according to an article published on Wiley, recent technological developments such as minimally invasive surgery (laparoscopic and robotics), image-guided surgery, and fluorescence-guided surgery are being implemented for Wilms Tumor.
  • Awareness and Support Initiatives: Increasing awareness about Wilms tumor and pediatric oncology, along with support initiatives from patient advocacy groups, contribute to the growth of the market. These efforts help in early detection, timely intervention, and improved patient outcomes, thus, boosting demand for Wilms tumor protein-related products and services.
  • Pediatric Oncology Healthcare Infrastructure: The availability of specialized pediatric oncology healthcare infrastructure and centers of excellence contributes to the growth of the Wilms tumor protein market. Well-equipped hospitals, skilled healthcare professionals, and comprehensive treatment facilities play a vital role in the effective management of Wilms tumor and the utilization of Wilms tumor protein-related diagnostics and therapies.

Wilms Tumor Protein Market Report Coverage

Report Coverage Details
Base Year: 2023 Market Size in 2023: US$ 2.92 Bn
Historical Data for: 2018 to 2022 Forecast Period: 2023 - 2030
Forecast Period 2023 to 2030 CAGR: 4.6% 2030 Value Projection: US$ 4 Bn
Geographies covered:
  • North America: U.S. and Canada
  • Latin America: Brazil, Argentina, Mexico, and Rest of Latin America
  • Europe: Germany, U.K., Spain, France, Italy, Russia, and Rest of Europe
  • Asia Pacific: China, India, Japan, Australia, South Korea, ASEAN, and Rest of Asia Pacific
  • Middle East: GCC, Israel and  Rest of Middle East
  • Africa:  North Africa, Central Africa and South Africa
Segments covered:
  • By Product Type: Antibodies, Assay Kits, Recombinant Proteins, and Others
  • By Application: Cancer Diagnosis, Cancer Treatment, Research and Development, and Others
  • By End User: Hospitals, Diagnostic Laboratories, Research Institutes, and Others
  • By Detection Method: Immunohistochemistry (IHC), Enzyme-Linked Immunosorbent Assay (ELISA), Western Blotting, Polymerase Chain Reaction (PCR), and Others
  • By Disease Stage: Diagnosis, and Monitoring and Prognosis
Companies covered:

Abcam plc, Thermo Fisher Scientific, Inc., Santa Cruz Biotechnology, Inc., Novus Biologicals, LLC, R&D Systems, Inc. (a subsidiary of Bio-Techne Corporation), OriGene Technologies, Inc., Cell Signaling Technology, Inc., Merck KGaA, BioLegend, Inc., Genetex, Inc. (a subsidiary of Novus Biologicals, LLC), Agilent Technologies, Inc., Proteintech Group, Inc., Sino Biological Inc., Boster Biological Technology, Fitzgerald Industries International

Growth Drivers:
  • Prevalence of Wilms Tumor
  • Advancements in Diagnostic Technologies
  • Awareness and Support Initiatives
  • Pediatric Oncology Healthcare Infrastructure
Restraints & Challenges:
  • Limited Awareness and Early Diagnosis
  • High Treatment Costs
  • Treatment Resistance and Disease Recurrence

Global Wilms Tumor Protein Market- Opportunities

  • Advancements in Precision Medicine: The growing understanding of the molecular pathways and genetic abnormalities associated with Wilms tumor presents opportunities for precision medicine approaches. For instance, in June 2022, GE Healthcare, a leading global medical technology company announced that it is advancing the future of precision medicine in oncology with new technology partners at #ASCO22. GE Healthcare partnered with companies such as RaySearch Laboratories, Elekta, Optellum, Vysioneer, Mirada Medical, and others to make advancements in precision medicine. Minerva Imaging Targeted therapies and personalized treatment strategies based on specific molecular markers, including the Wilms tumor protein, have the potential to improve treatment outcomes and minimize adverse effects.
  • Development of Novel Diagnostic Techniques: There is an opportunity for the development of novel diagnostic techniques for Wilms tumor, including the detection and analysis of the Wilms tumor protein. Advancements in imaging technologies, genetic testing methods, and molecular diagnostics can enhance early detection, accurate classification, and monitoring of Wilms tumor.
  • Integration of Artificial Intelligence and Data Analytics: The integration of artificial intelligence (AI) and data analytics presents opportunities for the analysis and interpretation of complex data related to Wilms tumor. AI algorithms and machine learning techniques can assist in identifying patterns, predicting outcomes, and guiding treatment decisions, contributing to more precise and personalized care.

Global Wilms Tumor Protein Market- Trends

  • Precision Medicine and Molecular Diagnostics: The trend towards precision medicine is impacting the Wilms tumor protein market growth. There is an increasing focus on understanding the molecular profile of Wilms tumor, including the expression and mutations of the Wilms tumor protein. Molecular diagnostics and genetic testing play a significant role in identifying specific biomarkers and tailoring to treatment strategies accordingly.
  • Targeted Therapies and Immunotherapies: The development of targeted therapies and immunotherapies is a significant trend in the Wilms tumor protein market. Researchers are exploring novel treatment modalities that specifically target the pathways and molecular markers associated with Wilms tumor, including the Wilms tumor protein. Immunotherapies, such as immune checkpoint inhibitors, hold promise in enhancing the body's immune response against Wilms tumor cells.
  • Advancements in Imaging Technologies: Advancements in imaging technologies are improving the detection, staging, and monitoring of Wilms tumor. Techniques such as ultrasound, MRI, CT scans, and PET scans allow for better visualization and characterization of tumors, aiding in treatment planning and treatment response evaluation.

Global Wilms Tumor Protein Market- Restraints

  • Limited Awareness and Early Diagnosis: A major restraint in the Wilms tumor protein market is the lack of awareness and challenges associated with early diagnosis. Delayed or missed diagnosis can hinder timely intervention and affect treatment outcomes. Educational initiatives and awareness campaigns are needed to improve early detection and promote timely access to appropriate care.
  • High Treatment Costs: The cost of diagnostics, treatments, and supportive care can hamper the global Wilms tumor protein market growth. The availability and affordability of targeted therapies, immunotherapies, and advanced imaging technologies may vary across different healthcare systems, limiting access for some patients and impacting equitable care. For instance, according to an article published by National Library of Medicine, the monetary costs of Wilm’s Tumor treatment costs around US$20,074 in U.S. with on-going weekly costs account for the largest share of expenses rather than major one-time purchases. Novel discoveries and developments are being carried out to reduce the costs of the treatment.
  • Treatment Resistance and Disease Recurrence: Wilms tumor can sometimes develop treatment resistance or experience disease recurrence. This poses challenges in achieving long-term remission and requires further research and development of novel treatment strategies. Overcoming treatment resistance and improving long-term outcomes are important areas of focus in the Wilms tumor protein market.

Figure 2. Global Wilms Tumor Protein Market Share (%), by Type, 2023


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Global Wilms Tumor Protein Market- Recent Developments

  • Children’s Hospital Los Angeles uncover new clues to the origin of Wilms Tumor (2023):  On May 1, 2023, according to a study published by Advanced Science, scientists at the GOFARR Laboratory in Urology conducted a comparative analysis between kidney progenitor cells derived from a tumor and precursor cells obtained from a healthy kidney. Under normal circumstances, these precursor cells undergo maturation into functional kidney cells. However, when their early developmental processes are disrupted, these exhibit behavior reminiscent of cancer stem cells.
  • A new study focusing the organoid-on-chip model targeting Wilms tumor (2023): On August 23, 2023, the research team at Wyss Institute at Harvard University study utilized an innovative model known as an immune-infiltrated human kidney organoid-on-chip. In this model, they showed that a T cell bispecific antibody (TCB) designed to target an antigen associated with the Wilms tumor-1 protein (WT1-TCB) has the unique capability of recruiting immune cells, notably cytotoxic T cells (depicted in green), to specific clusters of podocytes (depicted in blue). This recruitment ultimately results in the destruction of these podocytes.
  • A new clinical phase 1 study evaluating CUE-102 (2022): In August 2022, the initial patient had received their first dose in a phase 1 dose escalation study registered under NCT05360680. This study is investigating CUE-102, a member of the interleukin 2 (IL-2) series, as a standalone treatment for individuals with recurrent or metastatic cancers that exhibit the presence of Wilms' Tumor 1 (WT1). According to an official press release from Cue Biopharma, a clinical-stage biopharmaceutical company, the research will specifically concentrate on colorectal, gastric, pancreatic, and ovarian cancers.

Acquisition and Partnerships

  • Acquisition of Abcam plc by Danaher Corporation (2023): On August 28, 2023, Abcam plc, a global leader in the supply of life science research tools, announced that it had entered into a definitive agreement. As per agreement, Danaher Corporation will acquire all of the outstanding shares of Abcam for US$ 24.00 per share in cash.
  • Acquisition of Olink Holding AB by Thermo Fisher Scientific Inc. (2023): On October 17, 2023, Thermo Fisher Scientific Inc., the global leader in supporting scientific endeavors, and Olink Holding AB, a prominent provider of cutting-edge proteomics solutions, jointly announced that their boards of directors had given the green light to Thermo Fisher's offer to purchase Olink at a price of US$ 26.00 for each common share in cash, equating to US$ 26.00 per American Depositary Share (ADS) in cash.
  • Collaboration between ERS Genomics Limited and Santa Cruz Biotechnology Inc (2023): On August 10, 2023, ERS Genomics Limited, a global leader in providing access to foundational patents covering CRISPR/Cas9 intellectual property and licensing announced a new license agreement with Santa Cruz Biotechnology Inc., a developer of biological products for medical research. This agreement is non-exclusive and provides SCBT with access to the ERS CRISPR/Cas9 patent portfolio.
  • Partnership between Bio-Techne Corporation and Cell Signaling Technology (2023): On February 14, 2023, Bio-Techne Corporation, a leading developer and manufacturer of high-quality purified proteins and reagent solutions and Cell Signaling Technology (CST), a privately held company that develops and produces medical reagents jointly announced the incorporation of Simple Western validation into CST antibodies. This enhancement offers researchers across various fields a more streamlined approach to investigating crucial molecular signaling pathways on a reliable and validated platform. The ability to obtain precise data swiftly and efficiently is essential for progress in drug discovery and development. This continued collaboration will enable an extended selection of Simple Western validated antibodies targeting various molecules in diverse disciplines.

Top companies in Global Wilms Tumor Protein Market

  • Abcam plc
  • Thermo Fisher Scientific, Inc.
  • Santa Cruz Biotechnology, Inc.
  • Novus Biologicals, LLC
  • R&D Systems, Inc. (a subsidiary of Bio-Techne Corporation)
  • OriGene Technologies, Inc.
  • Cell Signaling Technology, Inc.
  • Merck KGaA
  • BioLegend, Inc.
  • Genetex, Inc. (a subsidiary of Novus Biologicals, LLC)
  • Agilent Technologies, Inc.
  • Proteintech Group, Inc.
  • Sino Biological Inc.
  • Boster Biological Technology
  • Fitzgerald Industries International

Definition: Wilms tumor protein (WT1) is a transcription factor and tumor suppressor gene associated with Wilms tumor, a pediatric kidney cancer. WT1 plays a crucial role in kidney and gonadal development, and its dysregulation can lead to various cancers. It is also involved in regulating cell growth, differentiation, and apoptosis. Understanding WT1's functions is essential for cancer research and developing targeted therapies.

Frequently Asked Questions

Global Wilms tumor protein market is estimated to be valued at US$ 2.92 billion in 2023 and is expected to exhibit a CAGR of 4.6% between 2023 and 2030.

Prevalence of Wilms tumor and advancements in diagnostic technologies are expected to drive the market growth.

Antibodies is the leading product type segment in the market.

Limited awareness and early diagnosis and high treatment costsare expected to hinder the market growth over the forecast period.

Major players operating in the market are Abcam plc, Thermo Fisher Scientific, Inc., Santa Cruz Biotechnology, Inc., Novus Biologicals, LLC, R&D Systems, Inc. (a subsidiary of Bio-Techne Corporation), OriGene Technologies, Inc., Cell Signaling Technology, Inc., Merck KGaA, BioLegend, Inc., Genetex, Inc. (a subsidiary of Novus Biologicals, LLC), Agilent Technologies, Inc., Proteintech Group, Inc., Sino Biological Inc., Boster Biological Technology, Fitzgerald Industries International.

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