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Weight Based Dose Should Be Implemented In Immunotherapy of Cancer

Jun, 2021

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The study was conducted taking the data from the patients suffering from kidney, lungs, neck, head and melanoma over a time period of about five years.

Immunotherapy is a type of treatment system, where patient’s, immune system is stimulated to defy any medical condition like cancer. The treatment occurs in two mechanisms where a patients is stimulated with its own immune system, so that the body itself can detect the problem and act against its progression, or the patients are provided with different immune-activator like protein, antibodies etc., that can help boosting the immune system for a particular disease. This therapy is often known as “Biological therapy”, as body is acting against the disease on its own.

There are wide variety of immune therapy used in cancer treatment like, Cancer Vaccine, T-Cell Therapy, Monoclonal antibodies specific for inhibiting tumor checkpoints, oncolytic virus therapy etc.  UT Southwestern Medical Center, researchers in a study claims the effectivity of immunotherapy, against cancer patients, who are overweight, is much higher than light weighed patients. The study was conducted taking the data from the patients suffering from kidney, lungs, neck, head and melanoma over a time period of about five years.

Weight-based dosing in immunotherapy yielded better result as compared to fixed-dosing system in the lighter patients. Weight based dosing caused the patients to live with an average of 20 years, as compared to 16 months survival rate in light weighted patients.

This therapeutic system was also judged on the basis of differences in the tumor formation, along with different metastatic progression method in different cancers. The results were all the same with twice time period of survival as compared to fixed dose system. Our immune system, is a highly advanced and complex system, consisting of different cells, proteins and also certain specific organs. That is the main reason behind the weight based dosing as calculating BMI (Body Mass Index), and its implementation in dosing would be specific and more effective to yield positive outcome, as compared to the fixed system.

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