Nanotechnology-based platforms are gaining significant importance in research and product development due to the enormous benefits they offer in terms of drug stability, bioavailability, dosage, and shelf-life. Various types of nano-carriers or nanoparticles such as liposomes, magnetic particle, dendrimers, silver nanoparticle, silica nanoparticle, and polymeric micelles, carbon nanoparticles and drug-conjugate nanoparticles are used in different industries to cater specific needs.
A major issue with chemotherapy is that the available drugs are non-targeted. Free flowing drug particles can damage both healthy and cancerous cells. For improved effectiveness, anti-cancer drugs need to penetrate the tumor cells to reach the cytoplasm. With currently available techniques, this can be achieved by means of a direct injection into the tumor or administering a large dose of the drug which can lead to side effects, be painful and expensive. Therefore, researchers started exploring the magnetic particles to drive the drugs at the target location.
Use of magnetic nano-particles in healthcare applications began with diagnostics. Magnetic driven drug delivery technology uses an external magnetic field to drive the nano-crystals in the body to the target tumor site. Many studies on this technology have progressed towards achieving the goal of administering the drug to the target site. One of the researches also reflected use of magnetic nano-composite membranes in remotely operated drug delivery device that can aid controlling the drug release. Recently, Chinese researchers from Quingdou University of Science and Technology developed super-paramagnetic crystals that can be guided through the human body for drug delivery at target site. Super-paramagnetic crystals have been known for years, but the small size was a restringing factor in implementing this technology widely. Small crystals are hard to control and would clump together when a magnetic field is removed. Hence, the researchers developed crystals of a bit larger size which are more responsive to an external magnetic field.
Scientists in Singapore have developed a novel way to deliver cancer drugs in tumor cells using tiny drug-coated bubbles. The micro-sized bubbles are coated with the drug particles and iron oxide nanoparticles. Using magnet, the bubbles get accumulated around the targeted tumor cell. Then, using an ultrasound device, the bubbles are vibrated, directing the drug particles towards the target cell. Clinicians would be able to localize the anticancer drugs around a tumor and introduce the drug deep into the tumor issues. The study is estimated to enter the clinical trials in next eight to ten years.
Safe and effective drug delivery is a major challenge against the pharmaceutical and biotechnology companies. Nanoparticle drug delivery technology shows promising results for overcoming the issue of multi-drug resistance in antibiotic and cancer therapies. Moreover, advancement in research has enabled controlled and sustained release of drugs to decrease the dosage and provide long term effect of the drug. There is all-together a new wave of innovation in life science sector that delivers medicines at the targeted site in right dose.
A number of studies are being carried out globally on magnetic driven drug delivery technology. However, strong results for FDA approval and high investments are required to commercialize this technology in the near future.
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Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:
Preliminary Data Mining
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Coherent Statistical model
We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:
Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.
This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:
The primary research is conducted with the ecosystem players including, but not limited to:
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