Transthyretin Amyloidosis Treatment Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2017–2025

Transthyretin amyloidosis is a rare disease caused due to abnormal build-up of amyloidosis in the tissues of the body. The deposits of transthyretin amyloids cause illness due to damage in structure and function of the organs and moreover, they can affect any part of the body where deposits of transthyretin amyloids are present. The deposits mainly consists of abnormal, insoluble protein fibers called amyloid fibrils that are soluble in healthy people but when the protein is misfolded it becomes sticky and form a clump together, which is insoluble in nature and accumulate in the tissue.

Furthermore, there are around 30 different types of protein known to form amyloid, which result in different clinical conditions as different amyloidosis tend to affect different body organs. Transthyretin amyloidosis is progressive and rare fatal disease that destroys the nerve cells that governs the various functions of body. There are 2 types of transthyretin amyloidosis, namely, , transthyretin familial amyloid polyneuropathy and transthyretin familial amyloid cardiomyopathy. Among this, in transthyretin familial amyloid polyneuropathy nerves that control senses, movements, and involuntary bodily functions are affected. Whereas, in transthyretin familial amyloid cardiomyopathy the damage is caused to heart muscles and also impedes the heart’s ability to pump blood throughout the whole body.

Transthyretin Amyloidosis Treatment Market Taxonomy

By Disease Type

  • Transthyretin Familial Amyloid Polyneuropathy
  • Transthyretin Familial Amyloid Cardiomyopathy

By End User

  • Hospitals
  • Clinics
  • Ambulatory Surgical Centers

By Geography

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East
  • Africa

Rise in amount of transthyretin protein in the body expected to fuel the transthyretin amyloidosis treatment market

Transthyretin protein is formed in the body abundantly due to inherited transthyretin gene alteration that leads to transthyretin amyloids. According to Amyloidosis Foundation, there are approximately 126 different genetic variations in transthyretin amyloids. Transthyretin amyloids are not contagious but they are considered to be inherited as autosomal dominant disease that suggests a person needs to have a single copy of mutant gene. Each offspring’s have 50% chances of inheriting the gene from any one parent that suffers from transthyretin amyloids. As transthyretin amyloids leads to failure of any organ, it is important to treat the transthyretin amyloids, which is expected to favor the development of transthyretin amyloids treatment market.

Furthermore, according to Amyloidosis Foundation, medical statistics states that transthyretin amyloids is found approximately in the 4% of the U.S. African-American population which favors the growth of transthyretin amyloidosis treatment market.

Regional growth engines of the transthyretin amyloidosis treatment market

On the basis of regional segmentation, the transthyretin amyloids treatment market is segmented into North America, Europe, Asia Pacific, Latin America, Middle East and Africa. Moreover, most common variant in transthyretin amyloids are Val30Met, Thr60Ala, Leu58His, Ser77Tyr found in the U.S.. According to Amyloidosis Foundation, medical statistics states that the gene mutation for transthyretin amyloids is carried by approximately 1.5 million people in the U.S.. Whereas, tafamidis with trade name VYNDAQEL was first approved in Europe which is expected to favor the growth of transthyretin amyloidosis treatment market in Europe.

Furthermore, according to BioMed Central journal’s published data in March 2017, people from the Europe had highest number of TTR mutations, followed by the people from East Asia, the U.S., Central-South Asia and Africa, which is expected to favor the growth of transthyretin amyloidosis treatment market.

The key players dominating the transthyretin amyloidosis treatment market

Recently, in June 2017, the U.S. Food and Drug Administration FDA granted fast track designation to tafamidis which is the company’s investigational treatment for familial amyloid cardiomyopathy as there were no approved treatment in the U.S., manufacturers are innovating new treatment for transthyretin amyloidosis. The key players operating the market are Pfizer Inc., SOM Innovation Biotech, S.L., Valeant Pharmaceuticals International, Inc., Ionis Pharmaceuticals, Inc., and AstraZeneca plc.

Research Methodology

Coherent Market Insights followsa comprehensive research methodology focused on providing the most precise market analysis. The company leverages a data triangulation model which helps company to gauge the market dynamics and provide accurate estimates. Key components of the research methodologies followed for all our market reports include:

  • Primary Research (Trade Surveys and Experts Interviews)
  • Desk Research
  • Proprietor Data Analytics Model

In addition to this, Coherent Market Insights has access to a wide range of the regional and global reputed paid data bases, which helps the company to figure out the regional and global market trends and dynamics. The company analyses the industry from the 360 Degree Perspective i.e. from the Supply Side and Demand Side which enables us to provide granular details of the entire ecosystem for each study. Finally, a Top-Down approach and Bottom-Up approach is followed to arrive at ultimate research findings.


Smiley face

Coherent Market Insights desk research is based on a principle set of research techniques:

  • National level desk research: It Includes research analysis of regional players, regional regulatory bodies, regional trade associations, and regional organization.
  • Multinational level desk research: The research team keeps a track of multinational players, global regulatory bodies, global trade associations, and global organization.

Coherent Market Insights has a large amount of in-house repository of industry database. This is leveraged as a burner for initiating a new research study. Key secondary sources include:

  • Governmental bodies, National and international social welfare institutions, and organizations creating economic policies among others.
  • Trade association, National and international media and trade press.
  • Company Annual reports, SEC filings, Corporate Presentations, press release, news, and specification sheet of manufacturers, system integrators, brick and mortar - distributors and retailers, and third party online commerce players.
  • Scientific journals, and other technical magazines and whitepapers.
Smiley face

Preliminary Data Mining

The raw data is obtained through the secondary findings, in house repositories, and trade surveys. It is then filtered to ensure that the relevant information including industry dynamics, trends, and outlook is retained for further research process.

Data Standardization:

Holistic approach is used to ensure that the granular and uncommon parameters are taken into consideration to ensure accurate results. The information from the paid databases are further combined to the raw data in order to standardize it.

Coherent Statistical model

We arrive at our final research findings through simulation models. Coherent Data Analytics Model is a statistical tool that helps company to forecast market estimates. Few of the parameters considered as a part of the statistical model include:

  • Micro-economic indicators
  • Macro-economic indicators
  • Environmental indicators
  • Socio-political indicators
  • Technology indicators

Data Processing

Once the findings are derived from the statistical model, large volume of data is process to confirm accurate research results. Data analytics and processing tools are adopted to process large chunk of collected informative data. In case, a client customizes the study during the process, the research finding till then are benchmarked, and the process for new research requirement is initiated again.

Data Validation

This is the most crucial stage of the research process. Primary Interviews are conducted to validate the data and analysis. This helps in achieving the following purposes:

  • It provides first-hand information on the market dynamics, outlook, and growth parameters.
  • Industry experts validates the estimates which helps the company to cement the on-going research study.
  • Primary research includes online surveys, face-to face interviews, and telephonic interviews.

The primary research is conducted with the ecosystem players including, but not limited to:

  • Raw Material Suppliers
  • Manufacturers
  • System Integrators
  • Distributors
  • End-users

Choose License Type

"How Can I Help You" ?

Finding it difficult to find the research that would cater to your business demands? Give us a chance to help you. One of our Research Consultants will connect to provide a customized solution.

[email protected]

Key Benefits

  • Custom Research Solution

    Talk to our research consultant to design an exclusive report as per your research needs.

  • Customer Fulfilment

    We aim to fulfil client's research demands with tailored research solutions.

  • Quick Turnaround Time Reports

    We aim to provide research studies in quickest turnaround time and in a much cost effective manner.

  • 360-degree Approach

    We cover each industry from supply and demand side with an aim to provide a most holistic research study.

  • Assured Quality

    We strive to provide most accurate and reliable research findings in our research reports.