Wilson's disease is characterized by a disproportionate amount of copper in the body. The disease is genetic and it is a rare autosomal recessive disorder, with copper build up in the liver and the brain. If not diagnosed early, Wilson’s disease can be fatal. Symptoms include weakness, vomiting, tremors, anxiety, and personality changes. The primary reason for the disease is mutation in ATP7B or Wilson disease protein. Treatment of Wilson’s disease includes medication as well as dietary changes. Dietary changes include food with low copper content and avoidance of copper utensils. The complications of Wilson’s disease include cirrhosis, liver cancer, kidney damage, liver failure, nervous system problems, and in some extreme cases, death.
Wilson’s disease may lead to Kayser-Fleischer rings, which results from the deposition of copper in the eyes. People with Wilson’s disease with signs of nervous system disorder generally have Kayser-Fleischer rings. Nevertheless, the rings are estimated to be present in 40 to 66 percent of people who shows signs of liver damage only, according to National Center for Biotechnology Information (NCBI). Wilson’s disease is believed to affect one in 30,000 people. The disease occurs equally in men and women. Early detection is crucial to effective treatment.
As the population is rising at an alarming rate, the probability of occurrence of the disease increases proportionately, since Wilson’s disease is genetic. This in turn, is expected to fuel growth of the Wilson’s disease treatment market.
Wilson’s disease Treatment Taxonomy
On the basis of type of treatment, global Wilson’s disease treatment market is classified into:
On the basis of type of end user, the global Wilson’s disease treatment market is classified into:
Owing to advancements in medical sciences and initiatives by regulatory bodies such as National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Wilson’s Disease Association (WDA), the treatment options as well as awareness about Wilson’s disease treatment has increased substantially in the recent past. Although, signs and symptoms of the disease usually do not appear till 6 years of age, new cases of the disease have been reported from other age groups as well.
Rising population and early detection to drive the overall Wilson’s disease treatment market
Asia Pacific is poised to offer a lucrative opportunity for the growth of the Wilson’s disease treatment market. This is due to rise in population in the region, especially in countries such as China, and India, as well as increasing awareness and growth in the overall expenditure on healthcare. According to a research report titled ‘Wilson’s disease in Asia’, authored by Yue Zhang, Zhi-Ying Wu, the occurrence of Wilson’s disease in Asia may be higher than that of other parts of the world. According to Chu NS and Hung TP’s report titled ‘Geographic variations in Wilson's disease’, the incidence of Wilson’s disease varied from 12 to 29 per 100,000 in European population. However, according to Arima M, and Sano I’s report titled ‘Genetic studies of Wilson's disease in Japan’, the commonness in Asian countries excluding India varied from 33 to 68 per 100,000, which is substantially higher than that of the European population. Asia constitutes 60% of the world's current population. As the disease is hereditary, the chances of occurrence of Wilson’s disease in the future are much higher in the region; hence the growth potential of Wilson’s disease treatment market is fairly high in Asia. This in turn will help in the expansion of the overall Wilson’s disease treatment market during the forecast period.
Some of the medications used in Wilson’s disease treatment are chelating agents such as trientine and d-penicillamine, and zinc, in addition to dietary modifications. Some of the companies operating in the market are SGPharma Pvt. Ltd., Valeant Pharmaceuticals, tsumura & Co., Merck & Co., VHB Life Science Inc. (Cardion), and Teva Pharmaceuticals USA, Inc.
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