The Global Pemetrexed Market, by Strength (100 mg and 500 mg), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa), is estimated to be valued at US$ 2,287.2 Million in 2022 and is projected to exhibit a CAGR of 2.2% over the forecast period (2022– 2030).
Eli Lilly and Company is dedicated to expand the indication of Alimta (Pemetrexed), such expansion of indication is expected to support global pemetrexed market growth. For instance, in June 2018, Eli Lilly and Company, a pharmaceutical company, announced that ALIMTA (pemetrexed for injection) received US FDA (Food and Drug Administration) approval for an additional indication for the combination with carboplatin plus pembrolizumab as first-line treatment for metastatic nonsquamous non-small cell lung cancer (NSCLC), irrespective of PD-L1 expression status. The approval was based on tumor response rate and progression-free survival.
Moreover, on March 24, 2022, Eli Lilly and Company, a pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has issued a complete response letter (CRL) for the Biologics License Application (BLA) for the investigational medicine sintilimab injection, PD-1 inhibitor in combination with pemetrexed and platinum chemotherapy for the first-line treatment of people with nonsquamous non-small cell lung cancer (NSCLC). Sintilimab is being developed by Innovent Biologics, Inc., a biopharmaceutical company and Lilly. Sintilimab is a type of immunoglobulin G4 monoclonal antibody, which binds to PD-1 molecules on the surface of T-cells, blocks the PD-1 / PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.
Global Pemetrexed Market – Impact of Coronavirus (COVID-19) Pandemic
The coronavirus or COVID-19 outbreak started in Wuhan, China in 2019 and has spread across all the continents of the world, affecting various industries globally. The economy in countries all over the world such as India, Italy, Bangladesh, Sri Lanka, the U.S., Morocco, and others has been disrupted due to lockdowns implemented by governments to combat the spread of coronavirus since 2020.
Increasing number of appointment cancellation and postponement during the pandemic hindered the market growth of pemetrexe globally. For instance, in January 2022, BMC, part of Springer nature, an online research journal published a report which reported that, respiration therapy and physical therapy were unavailable for 57% to 70% of patients during the pandemic in Germany. Appointments for tumor-directed therapy, tumor imaging, and follow-up care were postponed or cancelled for 18.9%, 13.6%, and 14.8% of patients, respectively in Germany.
Thus, impact of the Coronavirus (COVID-19) pandemic hindered the growth of global pemetrexed market during the forecast period.