Global Tooth Regeneration Market, by Application (Enamel, Dentin, Pulp), by Population Demographics (Geriatric, Middle-aged, Adults, Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) is estimated to be valued at US$ 4530.6 Million in 2022 and is expected to exhibit a CAGR of 5.8% during the forecast period (2022-2030), as highlighted in a new report published by Coherent Market Insights.

Patient focused innovation along with rise in geriatric population is expected to create lucrative growth opportunities for market players. Historically, the dental industry has been highly lucrative for industry players, with average 5.5% annual growth rate globally. Growth in the dental industry has been on upward trend since last two decades. As a result, industry players have generated high ROI over the last two decades, despite the industry being highly fragmented. The future, is predicted to be completely different – with disruptive dental technology underway. The companies are investing lump sum amount towards development of biologically engineered tooth regeneration for better dental treatment modalities.

Global Tooth Regeneration Market– Impact of Coronavirus (COVID-19) Pandemic

The COVID-19 pandemic and lockdowns in various countries across the globe have impacted the financial status of businesses across all sectors, including the private healthcare sector. The COVID-19 pandemic has impacted the entire supply chain of the healthcare industry, mainly due to strict lockdown in several regions. Private healthcare is one such sector that has been impacted significantly by the COVID-19 pandemic.

However, the COVID-19 pandemic had a negative impact on the global tooth regeneration market, due to decrease in research and development for tooth regeneration process during COVID-19 pandemic. For instance, in July 2020,  according to data published by the  National Center for Biotechnology Information, COVID-19 has led to closure and reduced hours of dental practices except for emergency and urgent services, limiting routine care and prevention.  The research and development of vaccine for COVID -19 was priority during the pandemic. Almost all the researchers and the healthcare professionals, were engaged in the clinical trials for developing vaccines to prevent coronavirus infection. The labs were engaged in the diagnosis and examination of corona patients. Hence, the research and development activities for the tooth regeneration were put on hold during pandemic.

Global Tooth Regeneration Market: Key Developments

In March 2021, Kyoto University, Research University based in Japan and University of Fukui, based in Japan, carried out a new study that an antibody for one gene -- uterine sensitization associated gene-1 or USAG-1 -- can stimulate tooth growth in mice suffering from tooth agenesis, a congenital condition. The paper was published in Science Advances. Although, the normal adult mouth has 32 teeth, about 1% of the population has more or fewer due to congenital conditions. Scientists have explored the genetic causes for cases having too many teeth as clues for regenerating teeth in adults. USAG-1 interacts with both basic metabolic panel (BMP) and Wnt (Wingless-related integration site). As a result, several of the antibodies led to poor birth and survival rates of the mice, affirming the importance of both BMP and Wnt on whole body growth. One promising antibody, however, disrupted the interaction of USAG-1 with BMP only. Experiments with this antibody revealed that BMP signaling is essential for determining the number of teeth in mice. Moreover, a single administration was enough to generate a whole tooth. Subsequent experiments showed the same benefits in ferrets. The study is the first to show the benefits of monoclonal antibodies on tooth regeneration and provides a new therapeutic framework for a clinical problem that can currently only be resolved with implants and other artificial measures.

Browse 8 Market Data Tables and 17 Figures spread through 120 Pages and in-depth TOC on “Global Tooth Regeneration Market”-  Forecast to 2030, Global Tooth Regeneration Market, by Application (Enamel, Dentin, Pulp), by Population Demographics (Geriatric, Middle-aged, Adults, Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa)

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Key Takeaways of the Global Tooth Regeneration Market:

  • The global tooth regeneration market is expected to exhibit a CAGR of 5.8% during the forecast period due to the increasing research and development activities to develop lozenges that rebuild tooth enamel. For instance, in March 2021, according to University of Washington, a public research university, there the researcher’s team is preparing to launch clinical trials of a lozenge that contains a genetically engineered peptide, or chain of amino acids, along with phosphorus and calcium ions, which are building blocks of tooth enamel. The peptide is derived from amelogenin, the key protein in the formation of tooth enamel, the tooth’s crown. It is also key to the formation of cementum, which makes up the surface of the tooth root. Each lozenge deposits several micrometers of new enamel on the teeth via the peptide, which is engineered to bind to the damaged enamel to repair it while not affecting the mouth’s soft tissue. The new layer also integrates with dentin, the living tissue underneath the tooth’s surface. Two lozenges a day can rebuild enamel, while one a day can maintain a healthy layer.
  • Enamel erosion is one of the most prevalent dental issue worldwide, which also results in other dental problems related to dentin and pulp. Researchers at the University of Southern California, are working on developing a technique using matrix metalloproteinase-20 (MMP-20), an enzyme found only in teeth, and an amelogenin-chitosan hydrogel to repair early tooth decay by growing an enamel-like layer.
  • Major players operating in the global tooth regeneration market include Institute Straumann AG, DENTSPLY Sirona, Datum Dental, Camlog Biotechnologies AG, BioHorizons, Unilever, 3M, Zimmer Biomet, Ocata Therapeutics, Integra LifeSciences, CryoLife, BioMimetic Therapeutic, Cook Medical, Stem Cells Inc.


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